Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 383, Issue 7-8

Issues

Discovery of Chemokine Substrates for Matrix Metalloproteinases by Exosite Scanning: A New Tool for Degradomics

C. M. Overall / G. A. McQuibban / I. Clark-Lewis
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.114

Abstract

Increasingly it is being recognized that matrix metalloproteinases (MMPs) are important processing enzymes that regulate cellular behaviour and immune cell function by selective proteolysis of cell surface receptors and adhesion molecules, cytokines and growth factors. These functions will likely prove to be as important in vivo as the proposed roles of MMPs in pathological matrix degradation. To screen for new protease substrates we have reported a novel exosite scanning strategy that utilizes protease substrate binding exosite domains as yeast twohybrid baits. We discovered that the chemokine monocyte chemoattractant protein-3 (MCP-3) binds the hemopexin C domain of gelatinase A (MMP-2) leading to its efficient cleavage, converting an agonist to a potent receptor antagonist. We have now found that other MMPs cleave MCP-1, MCP-2, MCP-3, MCP-4, SDF 1α and SDF-1β indicating that the intersection between the chemokine and MMP families is broad with important implications for the control of inflammatory and immune processes. Use of engineered substrates with altered exosite binding affinities further revealed the power of exosites in dictating proteolytic specificity either directing cleavage of nonpreferred sites or in other cases virtually eliminating proteolysis of readily accessible scissile bonds. Hence, bioinformatic searches for protease substrates based on scissile bond preference will only reveal a subset of substrates unless the influence of exosites is considered.

About the article

Published Online: 2005-06-01

Published in Print: 2002-08-27


Citation Information: Biological Chemistry, Volume 383, Issue 7-8, Pages 1059–1066, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.114.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Ming Cheng Liu, Veronica Akle, Wenrong Zheng, Jitendra R. Dave, Frank C. Tortella, Ronald L. Hayes, and Kevin K. W. Wang
Biochemical Journal, 2006, Volume 394, Number 3, Page 715
[2]
Ilya Sotnikov, Rami Hershkoviz, Valentin Grabovsky, Neta Ilan, Liora Cahalon, Israel Vlodavsky, Ronen Alon, and Ofer Lider
The Journal of Immunology, 2004, Volume 172, Number 9, Page 5185
[3]
Kendra J. Greenlee, David B. Corry, David A. Engler, Risë K. Matsunami, Philippe Tessier, Richard G. Cook, Zena Werb, and Farrah Kheradmand
The Journal of Immunology, 2006, Volume 177, Number 10, Page 7312
[4]
Julie Sanchez, J. Robert Lane, Meritxell Canals, and Martin J. Stone
International Journal of Molecular Sciences, 2019, Volume 20, Number 10, Page 2417
[5]
Toni Kline, Michael Y. Torgov, Brian A. Mendelsohn, Charles G. Cerveny, and Peter D. Senter
Molecular Pharmaceutics, 2004, Volume 1, Number 1, Page 9
[6]
Débora Alvarenga, Matheus Mattos, Mateus Lopes, Sarah Marchesi, Alan Araújo, Brenda Nakagaki, Mônica Santos, Bruna David, Viviane De Souza, Érika Carvalho, Rafaela Sousa Pereira, Pedro Marques, Kassiana Mafra, Hortência de Castro Oliveira, Camila de Miranda, Ariane Diniz, Thiago de Oliveira, Mauro Teixeira, Rafael Rezende, Maísa Antunes, and Gustavo Menezes
Cells, 2018, Volume 7, Number 12, Page 247
[7]
Sonali R. Bhagwat, Krishnan Hajela, and Amit Kumar
PROTEOMICS, 2018, Page 1800011
[8]
Sarah L. King, Christoffer K. Goth, Ulrich Eckhard, Hiren J. Joshi, Amalie D. Haue, Sergey Y. Vakhrushev, Katrine T. Schjoldager, Christopher M. Overall, and Hans H. Wandall
Journal of Biological Chemistry, 2018, Volume 293, Number 20, Page 7629
[9]
Elke Roeb, Marlies Arndt, Bettina Jansen, Volker Schumpelick, and Siegfried Matern
International Journal of Colorectal Disease, 2004, Volume 19, Number 6, Page 518
[10]
Junko Ueda, Masahiro Kajita, Naoko Suenaga, Katsuyuki Fujii, and Motoharu Seiki
Oncogene, 2003, Volume 22, Number 54, Page 8716
[11]
Wenzhao Li, Shigehira Saji, Fumiaki Sato, Makoto Noda, and Masakazu Toi
The International Journal of Biological Markers, 2013, Volume 28, Number 2, Page 117
[12]
Theo Klein, Ulrich Eckhard, Antoine Dufour, Nestor Solis, and Christopher M. Overall
Chemical Reviews, 2017
[13]
Richard M. Ransohoff
Nature Neuroscience, 2003, Volume 6, Number 10, Page 1009
[14]
E. Dimitriadis, C.A. White, R.L. Jones, and L.A. Salamonsen
Human Reproduction Update, 2005, Volume 11, Number 6, Page 613
[15]
J. Attia, K. Boumédiène, J.P. Pujol, J.M. Valleton, E. Huet, and Q.T. Nguyen
Journal of Bioactive and Compatible Polymers, 2009, Volume 24, Number 4, Page 329
[16]
Alain Doucet, Georgina S. Butler, David Rodríguez, Anna Prudova, and Christopher M. Overall
Molecular & Cellular Proteomics, 2008, Volume 7, Number 10, Page 1925
[17]
Estefanía Ugarte-Berzal, Jennifer Vandooren, Elvira Bailón, Ghislain Opdenakker, and Angeles García-Pardo
Journal of Biological Chemistry, 2016, Volume 291, Number 22, Page 11751
[18]
Jennifer H. Cox, Richard A. Dean, Clive R. Roberts, and Christopher M. Overall
Journal of Biological Chemistry, 2008, Volume 283, Number 28, Page 19389
[19]
Nathan V. Lee, Juan Carlos Rodriguez-Manzaneque, Shelley N.-M. Thai, Waleed O. Twal, Alfonso Luque, Karen M. Lyons, W. Scott Argraves, and M. Luisa Iruela-Arispe
Journal of Biological Chemistry, 2005, Volume 280, Number 41, Page 34796
[20]
Zichen Li, Takahisa Takino, Yoshio Endo, and Hiroshi Sato
Cancer Science, 2017, Volume 108, Number 3, Page 347
[21]
Gongchi Li, Xinhua Zou, Youpeng Zhu, Jing Zhang, Lijun Zhou, Dan Wang, Binghui Li, and Zhenbing Chen
The International Journal of Lower Extremity Wounds, 2017, Volume 16, Number 1, Page 6
[22]
Christian Hess and Dario Neri
Experimental Biology and Medicine, 2014, Volume 239, Number 7, Page 842
[23]
C. Chaussain-Miller, F. Fioretti, M. Goldberg, and S. Menashi
Journal of Dental Research, 2006, Volume 85, Number 1, Page 22
[24]
Nabin Malla, Eli Berg, Ugo Moens, Lars Uhlin-Hansen, Jan-Olof Winberg, and Donald Gullberg
PLoS ONE, 2011, Volume 6, Number 6, Page e20616
[25]
Prasanna Venkatraman, Satish Balakrishnan, Shashidhar Rao, Yogesh Hooda, Suyog Pol, and Andreas Hofmann
PLoS ONE, 2009, Volume 4, Number 5, Page e5700
[26]
Claire V. Reeves, Xing Wang, Pelisa C. Charles-Horvath, Joy Y. Vink, Valeriya Y. Borisenko, John A. T. Young, Jan K. Kitajewski, and F. Gisou van der Goot
PLoS ONE, 2012, Volume 7, Number 4, Page e34862
[27]
Angus M. Tester, Jennifer H. Cox, Andrea R. Connor, Amanda E. Starr, Richard A. Dean, Xose S. Puente, Carlos López-Otín, Christopher M. Overall, and Derya Unutmaz
PLoS ONE, 2007, Volume 2, Number 3, Page e312
[28]
Bénédicte Cauwe and Ghislain Opdenakker
Critical Reviews in Biochemistry and Molecular Biology, 2010, Volume 45, Number 5, Page 351
[29]
Ulrich Eckhard, Pitter F. Huesgen, Oliver Schilling, Caroline L. Bellac, Georgina S. Butler, Jennifer H. Cox, Antoine Dufour, Verena Goebeler, Reinhild Kappelhoff, Ulrich auf dem Keller, Theo Klein, Philipp F. Lange, Giada Marino, Charlotte J. Morrison, Anna Prudova, David Rodriguez, Amanda E. Starr, Yili Wang, and Christopher M. Overall
Matrix Biology, 2016, Volume 49, Page 37
[30]
Noemi Cifani, Maria Proietta, Luigi Tritapepe, Cira Di Gioia, Livia Ferri, Maurizio Taurino, and Flavia Del Porto
Annals of Medicine, 2015, Volume 47, Number 6, Page 441
[31]
Netta Sela-Passwell, Gabriel Rosenblum, Tsipi Shoham, and Irit Sagi
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010, Volume 1803, Number 1, Page 29
[32]
Maryam G. Rohani and William C. Parks
Matrix Biology, 2015, Volume 44-46, Page 113
[33]
E. M. Tam, C. J. Morrison, Y. I. Wu, M. S. Stack, and C. M. Overall
Proceedings of the National Academy of Sciences, 2004, Volume 101, Number 18, Page 6917
[34]
D. Vergote, G. S. Butler, M. Ooms, J. H. Cox, C. Silva, M. D. Hollenberg, J. H. Jhamandas, C. M. Overall, and C. Power
Proceedings of the National Academy of Sciences, 2006, Volume 103, Number 50, Page 19182
[35]
Nicolle L. Patterson, Rugmani Padmanabhan Iyer, Lisandra E. de Castro Brás, Yaojun Li, Thomas G. Andrews, Gregory J. Aune, Richard A. Lange, and Merry L. Lindsey
PROTEOMICS - Clinical Applications, 2013, Volume 7, Number 7-8, Page 516
[36]
Jeffrey J. Atkinson and Steven D. Shapiro
American Journal of Respiratory Cell and Molecular Biology, 2006, Volume 34, Number 6, Page 645
[37]
L. Guo, T. Takino, Y. Endo, T. Domoto, and H. Sato
Journal of Biochemistry, 2012, Volume 152, Number 5, Page 425
[38]
Laurie A. Shuman Moss, Sandra Jensen-Taubman, and William G. Stetler-Stevenson
The American Journal of Pathology, 2012, Volume 181, Number 6, Page 1895
[39]
Hala S. Alameddine
Neurobiology of Disease, 2012, Volume 48, Number 3, Page 508
[40]
Kiyoshi Komori, Takahiro Nonaka, Akiko Okada, Hiroaki Kinoh, Hiromi Hayashita-Kinoh, Nobuaki Yoshida, Ikuo Yana, and Motoharu Seiki
FEBS Letters, 2004, Volume 557, Number 1-3, Page 125
[41]
Katerina Ajami, Melissa R. Pitman, Claire H. Wilson, Joohong Park, R. Ian Menz, Amanda E. Starr, Jennifer H. Cox, Catherine A. Abbott, Christopher M. Overall, and Mark D. Gorrell
FEBS Letters, 2008, Volume 582, Number 5, Page 819
[42]
Léon C.L. van Kempen, Karin E. de Visser, and Lisa M. Coussens
European Journal of Cancer, 2006, Volume 42, Number 6, Page 728
[43]
Takahiro Domoto, Takahisa Takino, Luyang Guo, and Hiroshi Sato
Cancer Science, 2012, Volume 103, Number 3, Page 448
[44]
Boris Turk, Dušan Turk, and Vito Turk
The EMBO Journal, 2012, Volume 31, Number 7, Page 1630
[45]
W. Hornebeck, G. Bellon, and H. Emonard
Pathologie Biologie, 2005, Volume 53, Number 7, Page 405
[46]
María José Belmar, Carolina Pabst, Benjamin Martínez, and Marcela Hernández
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2008, Volume 105, Number 6, Page 801
[47]
Elin Hadler-Olsen, Bodil Fadnes, Ingebrigt Sylte, Lars Uhlin-Hansen, and Jan-Olof Winberg
FEBS Journal, 2011, Volume 278, Number 1, Page 28
[48]
[49]
Catherine Larochelle, Jorge Ivan Alvarez, and Alexandre Prat
FEBS Letters, 2011, Volume 585, Number 23, Page 3770
[50]
Sophie M. Chabot, Tyler S. Chernin, May Shawi, Jessica Wagner, Stephanie Farrant, David S. Burt, Sonya Cyr, and Marian R. Neutra
Vaccine, 2007, Volume 25, Number 29, Page 5348
[51]
Noriko Hattori, Satsuki Mochizuki, Kazuo Kishi, Tatsuo Nakajima, Hironari Takaishi, Jeanine D'Armiento, and Yasunori Okada
The American Journal of Pathology, 2009, Volume 175, Number 2, Page 533
[52]
Linda Favre-Kontula, Zoë Johnson, Tiana Steinhoff, Achim Frauenschuh, Francis Vilbois, and Amanda E.I. Proudfoot
Journal of Immunological Methods, 2006, Volume 317, Number 1-2, Page 152
[53]
Paul P. Tak
Best Practice & Research Clinical Rheumatology, 2006, Volume 20, Number 5, Page 929
[54]
Bénédicte Cauwe, Erik Martens, Philippe E. Van den Steen, Paul Proost, Ilse Van Aelst, Daniel Blockmans, and Ghislain Opdenakker
Experimental Cell Research, 2008, Volume 314, Number 15, Page 2739
[55]
Adrian Daneri-Navarro, Susana Del Toro-Arreola, Pedro Ernesto Sanchez-Hernandez, Maria Guadalupe Ramirez-Dueñas, J. Armendariz-Borunda, and Ruy Perez-Montfort
Gynecologic Oncology, 2005, Volume 98, Number 1, Page 111
[56]
C.C. Leonardo, A.A. Hall, L.A. Collier, P.E. Gottschall, and K.R. Pennypacker
Neuroscience, 2009, Volume 160, Number 4, Page 755
[57]
William Hornebeck, Elise Lambert, Emmanuelle Petitfrère, and Philippe Bernard
Biochimie, 2005, Volume 87, Number 3-4, Page 377
[58]
N.E. Sounni and A. Noel
Biochimie, 2005, Volume 87, Number 3-4, Page 329
[59]
Trevor Owens, Alicia A. Babcock, Jason M. Millward, and Henrik Toft-Hansen
Brain Research Reviews, 2005, Volume 48, Number 2, Page 178
[60]
Samantha J. Allen, Susan E. Crown, and Tracy M. Handel
Annual Review of Immunology, 2007, Volume 25, Number 1, Page 787
[61]
Bonnie F. Sloane, Mansoureh Sameni, Izabela Podgorski, Dora Cavallo-Medved, and Kamiar Moin
Annual Review of Pharmacology and Toxicology, 2006, Volume 46, Number 1, Page 301
[62]
C.M. Overall, E.M. Tam, R. Kappelhoff, A. Connor, T. Ewart, C.J. Morrison, X. Puente, C. López-Otín, and A. Seth
Biological Chemistry, 2004, Volume 385, Number 6
[63]
Petra Van Damme, Joel Vandekerckhove, and Kris Gevaert
Biological Chemistry, 2008, Volume 389, Number 4
[64]
Moustafa A. Sakr, Takahisa Takino, Takahiro Domoto, Hiroshi Nakano, Richard W. Wong, Motoko Sasaki, Yasuni Nakanuma, and Hiroshi Sato
Cancer Science, 2010, Volume 101, Number 11, Page 2368
[65]
Lydia Sorokin
Nature Reviews Immunology, 2010, Volume 10, Number 10, Page 712
[66]
Christopher M. Overall and Carl P. Blobel
Nature Reviews Molecular Cell Biology, 2007, Volume 8, Number 3, Page 245
[67]
Andrea Page-McCaw, Andrew J. Ewald, and Zena Werb
Nature Reviews Molecular Cell Biology, 2007, Volume 8, Number 3, Page 221
[68]
Evette S. Radisky and Derek C. Radisky
Journal of Mammary Gland Biology and Neoplasia, 2010, Volume 15, Number 2, Page 201
[69]
Aaron A. Hall and Keith R. Pennypacker
Translational Stroke Research, 2010, Volume 1, Number 2, Page 85
[70]
Taizo Tomari, Naohiko Koshikawa, Takayuki Uematsu, Takashi Shinkawa, Daisuke Hoshino, Nagayasu Egawa, Toshiaki Isobe, and Motoharu Seiki
Cancer Science, 2009, Volume 100, Number 7, Page 1284
[71]
Osmo Kari, Marko Määttä, Taina Tervahartiala, Sirje Peltonen, Marjatta Kari, Jaana Hagström, Timo Sorsa, Matti Saari, and Tari Haahtela
Graefe's Archive for Clinical and Experimental Ophthalmology, 2009, Volume 247, Number 5, Page 681
[72]
Marko Määttä, Osmo Kari, Taina Tervahartiala, Jaana Wahlgren, Sirje Peltonen, Marjatta Kari, Paula Rytilä, Matti Saari, and Timo Sorsa
Cornea, 2008, Volume 27, Number 3, Page 297
[73]
David Alonso-Escolano, Alex Y Strongin, Ada W Chung, Elena I Deryugina, and Marek W Radomski
British Journal of Pharmacology, 2004, Volume 141, Number 2, Page 241
[74]
Barry S. Flinn
Functional Plant Biology, 2008, Volume 35, Number 12, Page 1183
[75]
Jasper J Haringman, Roos L Oostendorp, and Paul P Tak
Expert Opinion on Emerging Drugs, 2005, Volume 10, Number 2, Page 299
[76]
H. Tan, K. Ye, Z. Wang, and H. Tang
Japanese Journal of Clinical Oncology, 2008, Volume 38, Number 8, Page 528
[77]
Marko Määttä, Osmo Kari, Taina Tervahartiala, Sirje Peltonen, Marjatta Kari, Matti Saari, and Timo Sorsa
Graefe's Archive for Clinical and Experimental Ophthalmology, 2006, Volume 244, Number 8, Page 957
[78]
Oliver Schilling and Christopher M Overall
Nature Biotechnology, 2008, Volume 26, Number 6, Page 685
[79]
Anjali K. Nath, Rachel M. Brown, Michael Michaud, M. Rocio Sierra-Honigmann, Michael Snyder, and Joseph A. Madri
The Journal of Cell Biology, 2008, Volume 181, Number 2, Page 367
[80]
Fredy Roberto Salazar Gutierrez, Manoj Mathew Lalu, Flávia Sammartino Mariano, Cristiane Maria Milanezi, Jonathan Cena, Raquel Fernanda Gerlach, Jose Eduardo Tanus Santos, Diego Torres‐Dueñas, Fernando Queiróz Cunha, Richard Schulz, and João Santana Silva
The Journal of Infectious Diseases, 2008, Volume 197, Number 10, Page 1468
[81]
Vincent Chabottaux and Agnès Noel
Clinical & Experimental Metastasis, 2007, Volume 24, Number 8, Page 647
[82]
I. D. Haidl, I. Falk, G. Nerz, and K. Eichmann
Scandinavian Journal of Immunology, 2006, Volume 64, Number 3, Page 280
[83]
Marko M????tt??, Taina Tervahartiala, Eija Vesti, Juhani Airaksinen, and Timo Sorsa
Journal of Glaucoma, 2006, Volume 15, Number 3, Page 229
[84]
Cornelis F.M. Sier, Kim Zuidwijk, Henry J.M.A.A. Zijlmans, Roeland Hanemaaijer, Adri A. Mulder-Stapel, Frans A. Prins, Enno J. Dreef, Gemma G. Kenter, Gert Jan Fleuren, and Arko Gorter
International Journal of Cancer, 2006, Volume 118, Number 12, Page 2991
[85]
Karin E. de Visser, Alexandra Eichten, and Lisa M. Coussens
Nature Reviews Cancer, 2006, Volume 6, Number 1, Page 24

Comments (0)

Please log in or register to comment.
Log in