Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 383, Issue 7-8


Extracellular Proteases of Staphylococcus spp.

G. Dubin
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.116


Bacterial proteases secreted into an infected host may exhibit a wide range of pathogenic potentials. Staphylococci, in particular Staphylococcus aureus, are known to produce several extracellular proteases, including serine, cysteine and metalloenzymes. Their insensitivity to most human plasma protease inhibitors and, even more, the ability to inactivate some of these make the proteases potentially harmful. Indeed, several recent studies have shown that staphylococcal proteases are able to interact with the host defense mechanisms and tissue components as well as to modify other pathogenderived virulence factors. A tight, cell densitydependent control of proteolytic activity expression, similar to that of the welldefined virulence determinants, further suggests the role of staphylococcal proteases in the infection process. Consistently, alterations in coordinated expression of extracellular proteins markedly diminished the virulence. However, despite these data and the fact that a strain deficient in sspABC operon coding for serine (sspA) and cysteine (sspB) proteases was highly attenuated in virulence in the animal infection model, it was impossible to unambiguously demonstrate the importance of any particular protease as a virulence factor. Therefore, it can be assumed that the orchestrated expression and interaction of a variety of extracellular and cell surface proteins rather than any particular one is responsible for the staphylococcal pathogenicity and that the proteases apparently play an important role in this complex process. Such redundant mechanism is very well suited for promoting the survival of staphylococci under diverse environmental conditions encountered in the infected host.

About the article

Published Online: 2005-06-01

Published in Print: 2002-08-27

Citation Information: Biological Chemistry, Volume 383, Issue 7-8, Pages 1075–1086, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.116.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Alexander J. Laarman, Maartje Ruyken, Cheryl L. Malone, Jos A. G. van Strijp, Alexander R. Horswill, and Suzan H. M. Rooijakkers
The Journal of Immunology, 2011, Volume 186, Number 11, Page 6445
Arvind Dabhade, Priti Patel, and Ulhas Patil
Natural Product Communications, 2013, Volume 8, Number 10, Page 1934578X1300801
Koen Van Crombruggen, Thomas Vogl, Claudina Pérez-Novo, Gabriele Holtappels, and Claus Bachert
European Respiratory Journal, 2016, Volume 47, Number 1, Page 264
Ploysyne Rattanakaemakorn and Poonkiat Suchonwanit
BioMed Research International, 2019, Volume 2019, Page 1
Joanne M. Dupre, William L. Johnson, Alexander V. Ulanov, Zhong Li, Brian J. Wilkinson, and John E. Gustafson
Food Microbiology, 2019, Volume 82, Page 46
J. Hiroshi Morisaki, Peter A. Smith, Shailesh V. Date, Kimberly K. Kajihara, Chau Linda Truong, Zora Modrusan, Donghong Yan, Jing Kang, Min Xu, Ishita M. Shah, Robert Mintzer, Eric M. Kofoed, Tommy K. Cheung, David Arnott, Michael F. T. Koehler, Christopher E. Heise, Eric J. Brown, Man-Wah Tan, and Wouter L. W. Hazenbos
mBio, 2016, Volume 7, Number 5
Joe M. Mootz, Cheryl L. Malone, Lindsey N. Shaw, Alexander R. Horswill, and A. J. Bäumler
Infection and Immunity, 2013, Volume 81, Number 9, Page 3227
Cortney R. Halsey, Shulei Lei, Jacqueline K. Wax, Mckenzie K. Lehman, Austin S. Nuxoll, Laurey Steinke, Marat Sadykov, Robert Powers, Paul D. Fey, Anthony R. Richardson, and Michael S. Gilmore
mBio, 2017, Volume 8, Number 1
Jonas Elmwall, Jakub Kwiecinski, Manli Na, Abukar Ahmed Ali, Veronica Osla, Lindsey N. Shaw, Wanzhong Wang, Karin Sävman, Elisabet Josefsson, Johan Bylund, Tao Jin, Amanda Welin, Anna Karlsson, and Nancy E. Freitag
Infection and Immunity, 2017, Volume 85, Number 7
M. E. Powers, P. A. Smith, T. C. Roberts, B. J. Fowler, C. C. King, S. A. Trauger, G. Siuzdak, and F. E. Romesberg
Journal of Bacteriology, 2011, Volume 193, Number 2, Page 340
Zeyu Deng and Changshui Xu
Acta Biochimica et Biophysica Sinica, 2017, Volume 49, Number 11, Page 967
Giampiero Pietrocola, Carla Renata Arciola, Simonetta Rindi, Antonella Di Poto, Antonino Missineo, Lucio Montanaro, and Pietro Speziale
The International Journal of Artificial Organs, 2011, Volume 34, Number 9, Page 799
Natalia Stach, Magdalena Kalinska, Michal Zdzalik, Radoslaw Kitel, Abdulkarim Karim, Karol Serwin, Wioletta Rut, Katrine Larsen, Abeer Jabaiah, Magdalena Firlej, Benedykt Wladyka, Patrick Daugherty, Henning Stennicke, Marcin Drag, Jan Potempa, and Grzegorz Dubin
Structure, 2018
Sergio Martínez-García, Sandra Rodríguez-Martínez, Mario E. Cancino-Diaz, and Juan C. Cancino-Diaz
APMIS, 2018
Jae Murphy, Mahnaz Ramezanpour, Natalia Stach, Grzegorz Dubin, Alkis James Psaltis, Peter-John Wormald, and Sarah Vreugde
The Laryngoscope, 2017
David Pérez-Pascual, Aurelie Lunazzi, Ghislaine Magdelenat, Zoe Rouy, Alain Roulet, Celine Lopez-Roques, Robert Larocque, Tristan Barbeyron, Angélique Gobet, Gurvan Michel, Jean-François Bernardet, and Eric Duchaud
Frontiers in Microbiology, 2017, Volume 8
Giampiero Pietrocola, Giulia Nobile, Simonetta Rindi, and Pietro Speziale
Frontiers in Cellular and Infection Microbiology, 2017, Volume 7
Stephen A. Raverty, Linda D. Rhodes, Erin Zabek, Azad Eshghi, Caroline E. Cameron, M. Bradley Hanson, and J. Pete Schroeder
Scientific Reports, 2017, Volume 7, Number 1
Hideaki Kouzaki, Koji Matsumoto, Hirotaka Kikuoka, Tomohisa Kato, Ichiro Tojima, Shino Shimizu, Hirohito Kita, and Takeshi Shimizu
American Journal of Respiratory and Critical Care Medicine, 2017, Volume 195, Number 6, Page 737
Blaise R. Boles, Alexander R. Horswill, and Pascale Cossart
PLoS Pathogens, 2008, Volume 4, Number 4, Page e1000052
Rizwan Aslam, Céline Marban, Christian Corazzol, François Jehl, François Delalande, Alain Van Dorsselaer, Gilles Prévost, Youssef Haïkel, Corinne Taddei, Francis Schneider, Marie-Hélène Metz-Boutigue, and Stefan Bereswill
PLoS ONE, 2013, Volume 8, Number 7, Page e68993
Delphine Labrousse, Magali Perret, Davy Hayez, Sonia Da Silva, Cédric Badiou, Florence Couzon, Michèle Bes, Pascal Chavanet, Gérard Lina, François Vandenesch, Delphine Croisier-Bertin, Thomas Henry, and Suzan H. M. Rooijakkers
PLoS ONE, 2014, Volume 9, Number 6, Page e97546
Robert E. Jordan, Jeffrey Fernandez, Randall J. Brezski, Allison R. Greenplate, David M. Knight, T. Shantha Raju, and A. Simon Lynch
Immunology Letters, 2016, Volume 172, Page 29
Takahisa Imamura, Sumio Tanase, Grzegorz Szmyd, Andrzej Kozik, James Travis, and Jan Potempa
The Journal of Experimental Medicine, 2005, Volume 201, Number 10, Page 1669
Martin Vestergaard, Line E. Thomsen, Caroline T. Gottlieb, Hanne Ingmer, Sanne Gottschalk, Lone Gram, and Paul R. Hansen
Journal of Medical Microbiology, 2015, Volume 64, Number 12, Page 1504
Melissa Lee and Hugo Van Bever
Asia Pacific Allergy, 2014, Volume 4, Number 4, Page 230
Abderrahmen Merghni, Mouna Ben Nejma, Hajer Hentati, Aouni Mahjoub, and Maha Mastouri
Microbial Pathogenesis, 2014, Volume 73, Page 7
Gemma González-Ortiz, H. C. Quarles Van Ufford, S. Bart A. Halkes, Marta Cerdà-Cuéllar, Cees J. Beukelman, Roland J. Pieters, Rob M. J. Liskamp, José F. Pérez, and Susana M. Martín-Orue
Environmental Microbiology, 2014, Volume 16, Number 5, Page 1346
Yihun Mola, Anbessa Dabassa, and Shiferaw Demissie .
Research Journal of Microbiology, 2014, Volume 9, Number 1, Page 16
Eui Dong Son, Hyoung-June Kim, Taehun Park, Kyeho Shin, Il-Hong Bae, Kyung-Min Lim, Eun-Gyung Cho, and Tae Ryong Lee
Journal of Dermatological Science, 2014, Volume 74, Number 1, Page 64
Shailesh V. Date, Zora Modrusan, Michael Lawrence, J. Hiroshi Morisaki, Karen Toy, Ishita M. Shah, Janice Kim, Summer Park, Min Xu, Li Basuino, Liana Chan, Deborah Zeitschel, Henry F. Chambers, Man-Wah Tan, Eric J. Brown, Binh An Diep, and Wouter L. W. Hazenbos
The Journal of Infectious Diseases, 2014, Volume 209, Number 10, Page 1542
Ewa Burchacka, Michal Zdzalik, Justyna-Stec Niemczyk, Katarzyna Pustelny, Grzegorz Popowicz, Benedykt Wladyka, Adam Dubin, Jan Potempa, Marcin Sienczyk, Grzegorz Dubin, and Jozef Oleksyszyn
Protein Science, 2014, Volume 23, Number 2, Page 179
Karla D Passalacqua and Nicholas H Bergman
Future Microbiology, 2006, Volume 1, Number 4, Page 397
H. Kim, J. H. Jang, S. C. Kim, and J. H. Cho
Journal of Antimicrobial Chemotherapy, 2014, Volume 69, Number 1, Page 121
Yan Bao, Yajuan Li, Qiu Jiang, Liping Zhao, Ting Xue, Bing Hu, and Baolin Sun
International Journal of Medical Microbiology, 2013, Volume 303, Number 4, Page 190
Garry Laverty, Sean P Gorman, and Brendan F Gilmore
Future Microbiology, 2013, Volume 8, Number 4, Page 509
Sudhir Kumar Shukla and Toleti Subba Rao
The Journal of Antibiotics, 2013, Volume 66, Number 2, Page 55
Michal Zdzalik, Abdulkarim Y. Karim, Krzysztof Wolski, Pawel Buda, Kinga Wojcik, Sarah Brueggemann, Piotr Wojciechowski, Sigrun Eick, Ann-Marie Calander, Ing-Marie Jonsson, Malgorzata Kubica, Klaudia Polakowska, Jacek Miedzobrodzki, Benedykt Wladyka, Jan Potempa, and Grzegorz Dubin
FEMS Immunology & Medical Microbiology, 2012, Volume 66, Number 2, Page 220
Dirk Wildeboer, Fiona Jeganathan, Robert G. Price, and Ramadan A. Abuknesha
Analytical Biochemistry, 2009, Volume 384, Number 2, Page 321
Lance R. Thurlow, Gauri S. Joshi, and Anthony R. Richardson
FEMS Immunology & Medical Microbiology, 2012, Volume 65, Number 1, Page 5
Grzegorz M. Popowicz, Grzegorz Dubin, Justyna Stec-Niemczyk, Anna Czarny, Adam Dubin, Jan Potempa, and Tad A. Holak
Journal of Molecular Biology, 2006, Volume 358, Number 1, Page 270
Joanna Koziel and Jan Potempa
Cell and Tissue Research, 2013, Volume 351, Number 2, Page 325
Ghada A. Bin Saif, Marna E. Ericson, and Gil Yosipovitch
Experimental Dermatology, 2011, Volume 20, Number 12, Page 959
Silva Holtfreter, Julia Kolata, and Barbara M. Bröker
International Journal of Medical Microbiology, 2010, Volume 300, Number 2-3, Page 176
Benedykt Wladyka, Agata J. Kozik, Michal Bukowski, Anna Rojowska, Tomasz Kantyka, Grzegorz Dubin, and Adam Dubin
Biochimie, 2011, Volume 93, Number 5, Page 948
Eva Trost, Arwa Al-Dilaimi, Panagiotis Papavasiliou, Jessica Schneider, Prisca Viehoever, Andreas Burkovski, Siomar C Soares, Sintia S Almeida, Fernanda A Dorella, Anderson Miyoshi, Vasco Azevedo, Maria P Schneider, Artur Silva, Cíntia S Santos, Louisy S Santos, Priscila Sabbadini, Alexandre A Dias, Raphael Hirata, Ana L Mattos-Guaraldi, and Andreas Tauch
BMC Genomics, 2011, Volume 12, Number 1
Toshiro Takai and Shigaku Ikeda
Allergology International, 2011, Volume 60, Number 1, Page 25
R. Foelster Holst, S. Reitamo, R. Yankova, M. Worm, M. Kadurina, K. Thaci, T. Bieber, N. Tsankov, A. Enk, T. Luger, M. Duffy, and R. Tansley
Allergy, 2010, Volume 65, Number 12, Page 1594
Holger Rohde, Christoph Burdelski, Katrin Bartscht, Muzaffar Hussain, Friedrich Buck, Matthias A. Horstkotte, Johannes K.-M. Knobloch, Christine Heilmann, Mathias Herrmann, and Dietrich Mack
Molecular Microbiology, 2005, Volume 55, Number 6, Page 1883
Malgorzata Rzychon, Renata Filipek, Artur Sabat, Klaudia Kosowska, Adam Dubin, Jan Potempa, and Matthias Bochtler
Protein Science, 2009, Volume 12, Number 10, Page 2252
Malgorzata Rzychon, Artur Sabat, Klaudia Kosowska, Jan Potempa, and Adam Dubin
Molecular Microbiology, 2003, Volume 49, Number 4, Page 1051
Jeffrey S. Kavanaugh, Matthew Thoendel, and Alexander R. Horswill
Molecular Microbiology, 2007, Volume 65, Number 3, Page 780
Yusuke Hirasawa, Toshiro Takai, Toshinobu Nakamura, Kouichi Mitsuishi, Hendra Gunawan, Hajime Suto, Takasuke Ogawa, Xiao-Ling Wang, Shigaku Ikeda, Ko Okumura, and Hideoki Ogawa
Journal of Investigative Dermatology, 2010, Volume 130, Number 2, Page 614
Andrea Fritzer, Birgit Noiges, Daniela Schweiger, Angelika Rek, Andreas J. Kungl, Alexander von Gabain, Eszter Nagy, and Andreas L. Meinke
Biochemical Journal, 2009, Volume 422, Number 3, Page 533
Federico C. Beasley, Enrique D. Vinés, Jason C. Grigg, Qin Zheng, Suya Liu, Gilles A. Lajoie, Michael E. P. Murphy, and David E. Heinrichs
Molecular Microbiology, 2009, Volume 72, Number 4, Page 947
Alexander H. Penn, Tony E. Hugli, and Geert W. Schmid-Sch??nbein
Shock, 2007, Volume 27, Number 3, Page 296

Comments (0)

Please log in or register to comment.
Log in