Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

See all formats and pricing
More options …
Volume 383, Issue 7-8


Modulation of the Endosomal and Lysosomal Distribution of Cathepsins B, L and S in Human Monocytes/Macrophages

H. Schmid / R. Sauerbrei / G. Schwarz / E. Weber / H. Kalbacher / C. Driessen
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2002.143


Endosomal and lysosomal fractions of human monocytes/ macrophages prepared from buffy coats were analyzed for activities of cathepsins B, L and S, and expression of cathepsin proteins along with major histocompatibility complex class I and class II molecules under control and immunomodulatory conditions. While the total activity of cathepsins B, L, and S together remained unchanged in lysates of control cells during culture for 72 h, the subcellular distribution of cathepsin activities underwent a shift from a predominantly endosomal localization in freshly isolated cells to a lysosomal pattern after 72 h of culture. Interferonγ treatment for 72 h resulted in an upregulation of both major histocompatibility complex proteins and cathepsins with differential changes in cathepsin B, L and S activities in endosomes versus lysosomes. These changes suggest a remodeling of the endocytic machinery and imply different functions of cathepsins B, L and S during monocyte differentiation.

About the article

Published Online: 2005-06-01

Published in Print: 2002-08-27

Citation Information: Biological Chemistry, Volume 383, Issue 7-8, Pages 1277–1283, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2002.143.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Franziska Leich, Nadine Stöhr, Anne Rietz, Renate Ulbrich-Hofmann, and Ulrich Arnold
Journal of Biological Chemistry, 2007, Volume 282, Number 38, Page 27640
Frank Tacke, Florent Ginhoux, Claudia Jakubzick, Nico van Rooijen, Miriam Merad, and Gwendalyn J. Randolph
The Journal of Experimental Medicine, 2006, Volume 203, Number 3, Page 583
Izabela Berdowska
Clinica Chimica Acta, 2004, Volume 342, Number 1-2, Page 41
Manhui Pang, Ariel F. Martinez, Jay Jacobs, Wayne Balkan, and Bruce R. Troen
Biochemical and Biophysical Research Communications, 2005, Volume 328, Number 3, Page 756
Špela Konjar, Fangfang Yin, Matthew Bogyo, Boris Turk, and Nataša Kopitar-Jerala
FEBS Letters, 2010, Volume 584, Number 11, Page 2201
Wiebke Wendt, Xin-Ran Zhu, Hermann Lübbert, and Christine C. Stichel
Experimental Neurology, 2007, Volume 204, Number 2, Page 525
Katarina M. Luhr, Elin K. Nordström, Peter Löw, and Krister Kristensson
NeuroReport, 2004, Volume 15, Number 10, Page 1663
Gwendalyn J Randolph, Claudia Jakubzick, and Chunfeng Qu
Current Opinion in Immunology, 2008, Volume 20, Number 1, Page 52
Timo Burster, Alexander Beck, Simone Poeschel, Anita Øren, Daniel Baechle, Michael Reich, Olaf Roetzschke, Kirsten Falk, Bernhard O. Boehm, Sawsan Youssef, Hubert Kalbacher, Herman Overkleeft, Eva Tolosa, and Christoph Driessen
Immunology, 2007, Volume 121, Number 1, Page 82

Comments (0)

Please log in or register to comment.
Log in