Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 384, Issue 3


Retinoids Inhibit Human Epidermal Keratinocyte RNase P Activity

E. Papadimou / D. Pavlidou / B. Séraphin / D. Tsambaos / D. Drainas
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2003.051


Ribonuclease P (RNase P) is a ubiquitous and essential enzyme that endonucleolytically cleaves all tRNA precursors to produce the mature 5'-end. We have investigated the effect of synthetic rertinoids (all-trans retinoic acid, acitretin) and arotinoids (Ro 13-7410, Ro 15-0778, Ro, 13-6298 and Ro 15-1570) on RNase P activity isolated for the first time from normal human epidermal keratinocytes (NHEK). All tested compounds but one (Ro 15-1570) revealed a dose-dependent inhibition of RNase P activity, indicating that they may have a direct effect on tRNA biogenesis. Detailed kinetic analysis showed that all retinoids behave as classic competitive inhibitors. On the basis of the Ki values Ro 13-7410 was found to be the strongest inhibitor among all compounds tested.

About the article

Published Online: 2005-06-01

Published in Print: 2003-03-14

Citation Information: Biological Chemistry, Volume 384, Issue 3, Pages 457–462, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2003.051.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Theodoros Petridis, Dimitra Giannakopoulou, Vassiliki Stamatopoulou, Katerina Grafanaki, Christos G. Kostopoulos, Helen Papadaki, Christina J. Malavaki, Nikos K. Karamanos, Stathianna Douroumi, Dionysios Papachristou, George E. Magoulas, Dionissios Papaioannou, and Denis Drainas
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2016, Volume 107, Number 1, Page 32
Anastassios Vourekas, Eleftheria Vryzaki, Chrisavgi Toumpeki, Vassiliki Stamatopoulou, Alexandra Monastirli, Dionysios Tsambaos, and Denis Drainas
Experimental Dermatology, 2009, Volume 18, Number 2, Page 130

Comments (0)

Please log in or register to comment.
Log in