Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 384, Issue 4

Issues

The Role of Glutathione Peroxidases in Trypanosomatids

S. R. Wilkinson / J. M. Kelly
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2003.060

Abstract

Reactive oxygen species are the unwanted by-products of aerobic metabolism. To protect cells against their potentially lethal effects a series of pathways have evolved that are collectively called the oxidative defence system. In most eukaryotes, catalases and selenium-dependent glutathione peroxidases form the front line of defence against hydroperoxide-mediated damage. However, these activities are lacking in members of the Trypanosomatidae family of protozoan parasites. Instead these organisms contain several enzyme-mediated pathways for removal of hydroperoxides that are centred upon the unusual thiol trypanothione. Here we discuss the biochemical properties of one group of these enzymes, the non-selenium glutathione-dependent peroxidases, and outline the roles that they play in protecting the parasite against hydroperoxides associated with biological membranes.

About the article

Published Online: 2005-06-01

Published in Print: 2003-04-10


Citation Information: Biological Chemistry, Volume 384, Issue 4, Pages 517–525, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2003.060.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Renata María Spina Zapata, Esteban Lozano, Patricia Andrea Barrera, María Belén Agüero, Alejandro Tapia, Gabriela Egly Feresin, and Miguel Ángel Sosa
Phytomedicine, 2018
[2]
L. Dias, E.F. Peloso, A.F.P. Leme, C.M. Carnielli, C.N. Pereira, C.C. Werneck, S. Guerrero, and F.R. Gadelha
Experimental Parasitology, 2017
[3]
Paola García-Huertas, Ana María Mejía-Jaramillo, Carlos Renato Machado, Anna Cláudia Guimarães, and Omar Triana-Chávez
Royal Society Open Science, 2017, Volume 4, Number 9, Page 170773
[4]
Alex Silva de Gusmão, Roberto Esteves Pires Castanho, Rodrigo Franzoso Almeida de Andrade, Clarisse Moreno Farsetti, Andressa Boim Mathias, Altino Luiz Silva Therezo, and Luciamáre Perinetti Alves Martins
Revista da Sociedade Brasileira de Medicina Tropical, 2012, Volume 45, Number 1, Page 51
[5]
Helena Castro, Susana Romao, Sandra Carvalho, Filipa Teixeira, Carla Sousa, Ana M. Tomás, and Pedro Lagerblad Oliveira
PLoS ONE, 2010, Volume 5, Number 9, Page e12607
[6]
Alice Machado-Silva, Paula Gonçalves Cerqueira, Viviane Grazielle-Silva, Fernanda Ramos Gadelha, Eduardo de Figueiredo Peloso, Santuza Maria Ribeiro Teixeira, and Carlos Renato Machado
Mutation Research/Reviews in Mutation Research, 2016, Volume 767, Page 8
[7]
E.F. Peloso, L. Dias, R.M.L. Queiroz, A.F.P. Paes Leme, C.N. Pereira, C.M. Carnielli, C.C. Werneck, M.V. Sousa, C.A.O. Ricart, and F.R. Gadelha
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2016, Volume 1864, Number 1, Page 1
[8]
Zabdi González-Chávez, Viridiana Olin-Sandoval, José Salud Rodíguez-Zavala, Rafael Moreno-Sánchez, and Emma Saavedra
Biochimica et Biophysica Acta (BBA) - General Subjects, 2015, Volume 1850, Number 2, Page 263
[9]
Matheus Andrade Rajão, Carolina Furtado, Ceres Luciana Alves, Danielle Gomes Passos-Silva, Michelle Barbi de Moura, Bruno Luiz Schamber-Reis, Marianna Kunrath-Lima, Aline Araújo Zuma, João Pedro Vieira-da-Rocha, Juliana Borio Ferreira Garcia, Isabela Cecília Mendes, Sérgio Danilo Junho Pena, Andrea Mara Macedo, Glória Regina Franco, Nadja Cristhina de Souza-Pinto, Marisa Helena Gennari de Medeiros, Angela Kaysel Cruz, Maria Cristina Machado Motta, Santuza Maria Ribeiro Teixeira, and Carlos Renato Machado
Environmental and Molecular Mutagenesis, 2014, Volume 55, Number 4, Page 309
[10]
G. Monteiro, B. B. Horta, D. C. Pimenta, O. Augusto, and L. E. S. Netto
Proceedings of the National Academy of Sciences, 2007, Volume 104, Number 12, Page 4886
[11]
Gianni Colotti, Paola Baiocco, Annarita Fiorillo, Alberto Boffi, Elena Poser, Francesco Di Chiaro, and Andrea Ilari
Future Medicinal Chemistry, 2013, Volume 5, Number 15, Page 1861
[12]
Bruno Manta, Marcelo Comini, Andrea Medeiros, Martín Hugo, Madia Trujillo, and Rafael Radi
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013, Volume 1830, Number 5, Page 3199
[13]
[14]
Eduardo F. Peloso, Conrado C. Gonçalves, Thiago M. Silva, Luis Henrique G. Ribeiro, María Dolores Piñeyro, Carlos Robello, and Fernanda R. Gadelha
Archives of Biochemistry and Biophysics, 2012, Volume 520, Number 2, Page 117
[15]
Janine König and Alan H. Fairlamb
FEBS Journal, 2007, Volume 274, Number 21, Page 5643
[16]
Stéphane Herbette, Patricia Roeckel-Drevet, and Joël R. Drevet
FEBS Journal, 2007, Volume 274, Number 9, Page 2163
[17]
Juan Diego Maya, Bruce K. Cassels, Patricio Iturriaga-Vásquez, Jorge Ferreira, Mario Faúndez, Norbel Galanti, Arturo Ferreira, and Antonio Morello
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2007, Volume 146, Number 4, Page 601
[18]
Ana M Mejía-Jaramillo, Geysson J Fernández, Lina Palacio, and Omar Triana-Chávez
Parasites & Vectors, 2011, Volume 4, Number 1, Page 169
[19]
Maria Dolores Piñeyro, Adriana Parodi-Talice, Magdalena Portela, Diego G. Arias, Sergio A. Guerrero, and Carlos Robello
Journal of Proteomics, 2011, Volume 74, Number 9, Page 1683
[20]
Fred R. Opperdoes and Jean-Pierre Szikora
Molecular and Biochemical Parasitology, 2006, Volume 147, Number 2, Page 193
[21]
Patricio Portal, Silvia Fernández Villamil, Guillermo D. Alonso, Matias G. De Vas, Mirtha M. Flawiá, Héctor N. Torres, and Cristina Paveto
Molecular and Biochemical Parasitology, 2008, Volume 160, Number 1, Page 42
[22]
Marcelo A Comini, Sergio A Guerrero, Simon Haile, Ulrich Menge, Heinrich Lünsdorf, and Leopold Flohé
Free Radical Biology and Medicine, 2004, Volume 36, Number 10, Page 1289
[23]
Shane R. Wilkinson, S. Radhika Prathalingam, Martin C. Taylor, Aiyaz Ahmed, David Horn, and John M. Kelly
Free Radical Biology and Medicine, 2006, Volume 40, Number 2, Page 198
[24]
M. C. TAYLOR and J. M. KELLY
Parasitology, 2010, Volume 137, Number 06, Page 899
[25]
Shreenal Patel, Syeed Hussain, Richard Harris, Sunita Sardiwal, John M. Kelly, Shane R. Wilkinson, Paul C. Driscoll, and Snezana Djordjevic
Biochemical Journal, 2010, Volume 425, Number 3, Page 513
[26]
Shane R. Wilkinson and John M. Kelly
Expert Reviews in Molecular Medicine, 2009, Volume 11
[27]
L. Flohé, T. Jaeger, S. Pilawa, and H. Sztajer
Redox Report, 2003, Volume 8, Number 5, Page 256
[28]
Nathalie Vonlaufen, Stefan M. Kanzok, Ronald C. Wek, and William J. Sullivan Jr
Cellular Microbiology, 2008, Volume 10, Number 12, Page 2387

Comments (0)

Please log in or register to comment.
Log in