Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

See all formats and pricing



Select Volume and Issue


Age-Dependent Effects of Conditioning on Cholinergic and Vasopressin Systems in the Rat Suprachiasmatic Nucleus

B. A. M. Biemans / E. A. Van der Zee / S. Daan

Citation Information: Biological Chemistry. Volume 384, Issue 5, Pages 729–736, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2003.081, June 2005

Publication History

Published Online:


Active shock avoidance was used to explore the impact of behavioural stimulation on the neurochemistry of the suprachiasmatic nucleus. We have found previously that the expression of muscarinic acetylcholine receptors in the suprachiasmatic nucleus of young rats was significantly enhanced 24 hours after fear conditioning. Here, we investigated whether this observation is age-dependent. We used 26 month-old Wistar rats with a deteriorated circadian system, and compared them with young rats (4 months of age) with an intact circadian system. Vasopressin, representing a major output system of the suprachiasmatic nucleus, was studied in addition to muscarinic receptors. Young rats showed a significant increase in immunostaining for muscarinic acetylcholine receptors 24 h after training, corroborating earlier observations. Aged rats did not show such an increase. In contrast, aged rats did show an increase in vasopressin immunoreactivity 24 h after fear conditioning, both at the level of content and cell number, while young rats did not reveal a significant rise. Thus, it seems that these two neurochemical systems in the suprachiasmatic nucleus are regulated independently. The results further demonstrate that the circadian pacemaker is influenced by fear conditioning in an age-dependent manner.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

C. K. Mulder, M. P. Gerkema, and E. A. Van der Zee
Frontiers in Behavioral Neuroscience, 2016, Volume 9
Cornelis Kees Mulder, Christos Papantoniou, Menno P. Gerkema, and Eddy A. Van Der Zee
Chronobiology International, 2014, Volume 31, Number 9, Page 1075
E.A. Van der Zee and J.N. Keijser
Behavioural Brain Research, 2011, Volume 221, Number 2, Page 356
Eus J.W. Van Someren and Rixt F. Riemersma-Van Der Lek
Sleep Medicine Reviews, 2007, Volume 11, Number 6, Page 465
Eddy A. Van der Zee, Barbara A.M. Biemans, Menno P. Gerkema, and Serge Daan
Journal of Neuroscience Research, 2004, Volume 78, Number 4, Page 508

Comments (0)

Please log in or register to comment.