Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 384, Issue 5

Issues

Age-Dependent Effects of Conditioning on Cholinergic and Vasopressin Systems in the Rat Suprachiasmatic Nucleus

B. A. M. Biemans / E. A. Van der Zee / S. Daan
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2003.081

Abstract

Active shock avoidance was used to explore the impact of behavioural stimulation on the neurochemistry of the suprachiasmatic nucleus. We have found previously that the expression of muscarinic acetylcholine receptors in the suprachiasmatic nucleus of young rats was significantly enhanced 24 hours after fear conditioning. Here, we investigated whether this observation is age-dependent. We used 26 month-old Wistar rats with a deteriorated circadian system, and compared them with young rats (4 months of age) with an intact circadian system. Vasopressin, representing a major output system of the suprachiasmatic nucleus, was studied in addition to muscarinic receptors. Young rats showed a significant increase in immunostaining for muscarinic acetylcholine receptors 24 h after training, corroborating earlier observations. Aged rats did not show such an increase. In contrast, aged rats did show an increase in vasopressin immunoreactivity 24 h after fear conditioning, both at the level of content and cell number, while young rats did not reveal a significant rise. Thus, it seems that these two neurochemical systems in the suprachiasmatic nucleus are regulated independently. The results further demonstrate that the circadian pacemaker is influenced by fear conditioning in an age-dependent manner.

About the article

Published Online: 2005-06-01

Published in Print: 2003-05-15


Citation Information: Biological Chemistry, Volume 384, Issue 5, Pages 729–736, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2003.081.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
C. Mulder, E.A. Van Der Zee, R.A. Hut, and M.P. Gerkema
Journal of Biological Rhythms, 2013, Volume 28, Number 6, Page 367
[2]
C. K. Mulder, M. P. Gerkema, and E. A. Van der Zee
Frontiers in Behavioral Neuroscience, 2016, Volume 9
[3]
Cornelis Kees Mulder, Christos Papantoniou, Menno P. Gerkema, and Eddy A. Van Der Zee
Chronobiology International, 2014, Volume 31, Number 9, Page 1075
[4]
R.A. Hut and E.A. Van der Zee
Behavioural Brain Research, 2011, Volume 221, Number 2, Page 466
[5]
E.A. Van der Zee and J.N. Keijser
Behavioural Brain Research, 2011, Volume 221, Number 2, Page 356
[6]
Eus J.W. Van Someren and Rixt F. Riemersma-Van Der Lek
Sleep Medicine Reviews, 2007, Volume 11, Number 6, Page 465
[7]
Eddy A. Van der Zee, Barbara A.M. Biemans, Menno P. Gerkema, and Serge Daan
Journal of Neuroscience Research, 2004, Volume 78, Number 4, Page 508

Comments (0)

Please log in or register to comment.
Log in