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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 384, Issue 6


Revisiting Ubiquity and Tissue Specificity of Human Calpains

A. Farkas / P. Tompa / P. Friedrich
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2003.106


The abundance of mRNAs transcribed from human genes of the calpain superfamily was studied in 72 human tissues and cell types by the Human Multiple Tissue Expression (MTE™) Array technique. The analysis included the large subunits of u- and m-calpains, the small subunits, calpastatin and calpain 3 (p94). Besides specific data on transcriptional activity, two major conclusions emerged: (i) ubiquitous calpains are not expressed in all cell types, and (ii) a 'tissue-specific' calpain may be expressed in many cell types apart from the one in which it is particularly abundant. Therefore, the categoric classification of ubiquitous vs. 'tissue-specific' calpains is a simplification.

About the article

Published Online: 2005-06-01

Published in Print: 2003-06-16

Citation Information: Biological Chemistry, Volume 384, Issue 6, Pages 945–949, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2003.106.

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