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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

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IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

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1437-4315
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In This Section
Volume 385, Issue 1 (Jan 2004)

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Singlet oxygen-mediated damage to cellular DNA determined by the comet assay associated with DNA repair enzymes

J.-L. Ravanat / S. Sauvaigo / S. Caillat / G. R. Martinez / M. H. G. Medeiros / P. Di Mascio / A. Favier / J. Cadet
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2004.003

Abstract

The damage profile produced by the reaction of singlet molecular oxygen with cellular DNA was determined using the comet assay associated with DNA repair enzymes. Singlet oxygen was produced intracellularly by thermal decomposition of a watersoluble endoperoxide of a naphthalene derivative which is able to penetrate through the membrane into mammalian cells. We found that the DNA modifications produced by singlet oxygen were almost exclusively oxidised purines recognised by the formamidopyrimidine DNA N-glycosylase. In contrast, significant amounts of direct strand breaks and alkalilabile sites or oxidised pyrimidines, detectable by the bacterial endonuclease III, were not produced.

About the article

Published Online: 2005-06-01

Published in Print: 2004-01-05



Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2004.003. Export Citation

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