Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 385, Issue 10 (Oct 2004)

Issues

Roles of nectins in cell adhesion, migration and polarization

Hiroyuki Nakanishi
  • Department of Molecular Pharmacology, Kumamoto University Graduate School of Medical Sciences, Kumamoto 860-8556, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Yoshimi Takai
  • Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2004.116

Abstract

Nectins are Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecules, which comprise a family consisting of four members. Nectins have five activities: (1) they show Ca2+-independent cell-cell adhesion activity by homo- and hetero-trans-interactions through their extracellular regions; (2) they bind afadin, an actin filament (F-actin)-binding protein, through their cytoplasmic tails and are connected to the actin cytoskeleton; (3) they induce activation of Cdc42 and Rac small G proteins through their cytoplasmic tails; (4) they bind Par-3, a cell polarity protein, through their cytoplasmic tails; and (5) they heterophilically trans-interact with Necls, nectin-like molecules, through their extracellular regions. Through these activities, nectins regulate a variety of cellular functions, including adhesion, migration, and polarization. Here we describe these activities and functions of nectins.

Keywords: cadherins; cell adhesion; cell migration; cell polarization; nectins; Necls

About the article

Published Online: 2005-06-01

Published in Print: 2004-10-01


Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2004.116.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Yuan-Yuan Gao, Xiao-Ya Hong, and Hong-Jun Wang
Journal of Molecular Neuroscience, 2016, Volume 60, Number 2, Page 258
[2]
Shu Hisata, Toshiaki Sakisaka, Takeshi Baba, Tomohiro Yamada, Kazuhiro Aoki, Michiyuki Matsuda, and Yoshimi Takai
The Journal of Cell Biology, 2007, Volume 178, Number 5, Page 843
[3]
Melissa S. DeRycke, Stefan E. Pambuccian, C. Blake Gilks, Steve E. Kalloger, Abderrezak Ghidouche, Marc Lopez, Robin L. Bliss, Melissa A. Geller, Peter A. Argenta, Katherine M. Harrington, and Amy P.N. Skubitz
American Journal of Clinical Pathology, 2010, Volume 134, Number 5, Page 835
[4]
Adriana Sartorio Gehren, Murilo Ramos Rocha, Waldemir Fernandes de Souza, and José Andrés Morgado-Díaz
Tissue Barriers, 2015, Volume 3, Number 3, Page e1017688
[5]
Shengke Hou, Xiaodong Zheng, Haiming Wei, Zhigang Tian, and Rui Sun
International Immunopharmacology, 2014, Volume 19, Number 1, Page 119
[6]
Tomohiro Yamada, Kaori Kuramitsu, Etsuko Rikitsu, Souichi Kurita, Wataru Ikeda, Yoshimi Takai, and Eisuke Nishida
Genes to Cells, 2013, Volume 18, Number 11, Page 985
[7]
Carolina Epifano and Mirna Perez-Moreno
Cell Adhesion & Migration, 2012, Volume 6, Number 3, Page 261
[8]
Patricia G. Spear, Sharmila Manoj, Miri Yoon, Cheryl R. Jogger, Anna Zago, and Dawn Myscofski
Virology, 2006, Volume 344, Number 1, Page 17
[9]
Luis A. Aparicio, Manuel Valladares, Moisés Blanco, Guillermo Alonso, and Angélica Figueroa
Cancer and Metastasis Reviews, 2012, Volume 31, Number 1-2, Page 375
[10]
Sandrine Etienne-Manneville
Seminars in Cell & Developmental Biology, 2011, Volume 22, Number 8, Page 850
[11]
J.D. Aplin, C.J.P. Jones, and L.K. Harris
Placenta, 2009, Volume 30, Number 4, Page 293
[12]
Deborah L. Even, Allison M. Henley, and Robert J. Geraghty
Virus Research, 2006, Volume 119, Number 2, Page 195
[13]
Genaro Patiño-Lopez, Peter Hevezi, Jerry Lee, Dorian Willhite, Gail M. Verge, Sandra M. Lechner, Vianney Ortiz-Navarrete, and Albert Zlotnik
Journal of Neuroimmunology, 2006, Volume 171, Number 1-2, Page 145
[14]
Eunjoo Kim, Young Chae Chu, Jee Young Han, Don Haeng Lee, Ye Ji Kim, Hyun-Chul Kim, Se Geun Lee, Sung Jun Lee, Sang Won Jeong, and Joon Mee Kim
Toxicology and Environmental Health Sciences, 2010, Volume 2, Number 4, Page 251
[15]
Toshiaki Sakisaka, Wataru Ikeda, Hisakazu Ogita, Naoyuki Fujita, and Yoshimi Takai
Current Opinion in Cell Biology, 2007, Volume 19, Number 5, Page 593
[16]
Michel R. Popoff and Blandine Geny
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2009, Volume 1788, Number 4, Page 797
[17]
Yann Wallez and Philippe Huber
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008, Volume 1778, Number 3, Page 794
[19]
Carly Willenborg and Rytis Prekeris
Bioscience Reports, 2011, Volume 31, Number 4, Page 245
[20]
Hiroyuki Nakanishi and Yoshimi Takai
Journal of Cellular and Molecular Medicine, 2008, Volume 12, Number 4, Page 1169
[21]
[22]
Jakob W. von Trotha, José A. Campos-Ortega, and Alexander M. Reugels
Developmental Dynamics, 2006, Volume 235, Number 4, Page 967
[23]
Carlos R. Rosales, Kyle D. Osborne, Griselda V. Zuccarino, Peter Scheiffele, and Michael A. Silverman
European Journal of Neuroscience, 2005, Volume 22, Number 9, Page 2381
[24]
Meghan S. Adams, Laura S. Gammill, and Marianne Bronner-Fraser
Developmental Dynamics, 2008, Volume 237, Number 4, Page 1021
[26]
Clotilde Billottet, Marianne Tuefferd, David Gentien, Audrey Rapinat, Jean-Paul Thiery, Philippe Broët, and Jacqueline Jouanneau
Journal of Cellular Biochemistry, 2008, Volume 104, Number 3, Page 826
[27]
J. Vanover, J. Sun, S. Deka, J. Kintner, M. M. Duffourc, and R. V. Schoborg
Microbiology, 2008, Volume 154, Number 3, Page 971
[28]
Q. Wang and B. Margolis
Kidney International, 2007, Volume 72, Number 12, Page 1448
[29]
Srilekha Deka, Jennifer Vanover, Jingru Sun, Jennifer Kintner, Judy Whittimore, and Robert V. Schoborg
Cellular Microbiology, 2007, Volume 9, Number 3, Page 725
[30]
Misa Ozaki, Hisakazu Ogita, and Yoshimi Takai
Genes to Cells, 2007, Volume 12, Number 5, Page 651
[31]
M. Gruber-Olipitz, J.-W. Yang, I. Slavc, and G. Lubec
Amino Acids, 2006, Volume 30, Number 4, Page 409

Comments (0)

Please log in or register to comment.
Log in