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Thomas, Douglas D.

Biological Chemistry

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Volume 385, Issue 12 (Dec 2004)


Structural flexibility of small GTPases. Can it explain their functional versatility?

Ernst J.M. Helmreich
  • The Biocenter of the University of Würzburg, Am Hubland, D-97074 Würzburg, Germany
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2004.146


Multiple interactions with many different partners are responsible for the amazing functional versatility of proteins, especially those participating in cellular regulation. The structural properties that could facilitate multiple interactions are examined for small GTPases. The role of cellular constraints, compartmentation and scaffolds on protein-protein interactions is considered.

Keywords: cellular constraints; coupling versatility; flexible proteins; GTPase structure; small GTPases


About the article

Corresponding author ; Present address: Werner-von-siemens-Strasse 83, D-97076 Würzburg, Germany

Published Online: 2005-06-01

Published in Print: 2004-12-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2004.146. Export Citation

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