Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

See all formats and pricing
More options …
Volume 385, Issue 3-4 (Apr 2004)


Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS

M. G. Donner / U. Warskulat / N. Saha / D. Häussinger
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2004.029


Lipopolysaccharide (LPS) induces hepatocellular downregulation and endocytic retrieval of multidrug resistance protein 2 (Mrp2, Abcc2). Basolateral Mrp isoforms may compensate for the intracellular metabolic changes in cholestasis. Therefore, the effect of LPS on the zonal localization of Mrp2 and Mrp3 and the expression of Mrp3, Mrp4, Mrp5, and Mrp6 mRNA were investigated in rat liver. In normal rat liver Mrp3 was found in pericentral hepatocytes also expressing glutamine synthetase. In LPS-treated rat liver the decrease in Mrp2 protein was most pronounced in pericentral hepatocytes, with only minor down-regulation in periportal hepatocytes. Conversely, induction of Mrp3 was found in pericentral hepatocytes with a low expression of Mrp2. Furthermore, we found a strong induction of Mrp5 mRNA. Likewise, Mrp6 mRNA was upregulated, however Mrp6 protein expression was not significantly altered. It is concluded that Mrp3 is inversely regulated to Mrp2 in a zonal pattern and may compensate for the LPSinduced loss of Mrp2 in the perivenous area. Induction of pericentral Mrp3 and upregulation of Mrp5 mRNA may play an important role in the hepatocellular clearance of cholephilic substances and cyclic nucleotides accumulating after LPS treatment.

About the article

Published Online: 2005-06-01

Published in Print: 2004-04-13

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2004.029.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Peter Recknagel, Falk A. Gonnert, Martin Westermann, Sandro Lambeck, Amelie Lupp, Alain Rudiger, Alex Dyson, Jane E. Carré, Andreas Kortgen, Christoph Krafft, Jürgen Popp, Christoph Sponholz, Valentin Fuhrmann, Ingrid Hilger, Ralf A. Claus, Niels C. Riedemann, Reinhard Wetzker, Mervyn Singer, Michael Trauner, Michael Bauer, and Jean-Louis Vincent
PLoS Medicine, 2012, Volume 9, Number 11, Page e1001338
Marc Jenniskens, Lies Langouche, Yoo-Mee Vanwijngaerden, Dieter Mesotten, and Greet Van den Berghe
Intensive Care Medicine, 2016, Volume 42, Number 1, Page 16
Femke M. van de Water, Rosalinde Masereeuw, and Frans G. M. Russel
Drug Metabolism Reviews, 2005, Volume 37, Number 3, Page 443
Xinsheng Gu and Jose E. Manautou
Drug Metabolism Reviews, 2010, Volume 42, Number 3, Page 482
Andreas Geier, Martin Wagner, Christoph G. Dietrich, and Michael Trauner
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007, Volume 1773, Number 3, Page 283
Clifford M. Babbey, Jennifer C. Ryan, Erin M. Gill, Marwan S. Ghabril, Courtney R. Burch, April Paulman, and Kenneth W. Dunn
IntraVital, 2012, Volume 1, Number 1, Page 44
María Laura Ruiz, Juan Pablo Rigalli, Agostina Arias, Silvina Stella Maris Villanueva, Claudia Banchio, Mary Vore, Aldo Domingo Mottino, and Viviana Alicia Catania
Biochemical Pharmacology, 2013, Volume 86, Number 3, Page 401
Eva Ramboer, Tamara Vanhaecke, Vera Rogiers, and Mathieu Vinken
Drug Metabolism Reviews, 2013, Volume 45, Number 2, Page 196
Mie Rostved Rasmussen, Mette Sommerlund, and Søren Kragh Moestrup
Expert Review of Endocrinology & Metabolism, 2013, Volume 8, Number 1, Page 37
Jin Chai, Yu He, Shi-Ying Cai, Zhongyong Jiang, Huaizhi Wang, Qiong Li, Lei Chen, Zhihong Peng, Xiaochong He, Xiaoping Wu, Tianli Xiao, Rongquan Wang, James L. Boyer, and Wensheng Chen
Hepatology, 2012, Volume 55, Number 5, Page 1485
Peter Recknagel, Ralf A. Claus, Ute Neugebauer, Michael Bauer, and Falk A. Gonnert
Journal of Biophotonics, 2012, Volume 5, Number 7, Page 571
Emmanuel A. Ho and Micheline Piquette-Miller
Biochemical and Biophysical Research Communications, 2007, Volume 353, Number 3, Page 679
Maciej J. Zamek-Gliszczynski, Keith A. Hoffmaster, Ken-ichi Nezasa, Melanie N. Tallman, and Kim L.R. Brouwer
European Journal of Pharmaceutical Sciences, 2006, Volume 27, Number 5, Page 447
Alison E. Aitken, Terrilyn A. Richardson, and Edward T. Morgan
Annual Review of Pharmacology and Toxicology, 2006, Volume 46, Number 1, Page 123
Joost Wauters, Dieter Mesotten, Kenny Van Zwam, Jos van Pelt, Steven Thiessen, Anne-Sophie Dieudonné, Sara Vander Borght, Greet Van den Berghe, and Alexander Wilmer
Shock, 2010, Volume 34, Number 5, Page 508
M Arrese and S J Karpen
Clinical Pharmacology & Therapeutics, 2010, Volume 87, Number 4, Page 473
Eva Brcakova, Leos Fuksa, Jolana Cermanova, Gabriela Kolouchova, Milos Hroch, Petra Hirsova, Jirina Martinkova, Frantisek Staud, and Stanislav Micuda
Biological & Pharmaceutical Bulletin, 2009, Volume 32, Number 12, Page 1978
Stanislav Micuda, Leos Fuksa, Eva Brcakova, Jan Osterreicher, Jolana Cermanova, Norbert Cibicek, Jaroslav Mokry, Frantisek Staud, and Jirina Martinkova
Journal of Gastroenterology and Hepatology, 2008, Volume 23, Number 7pt2, Page e225
K. Sandy Pang, Michael Weiss, and Panos Macheras
The AAPS Journal, 2007, Volume 9, Number 2, Page E268
Verena Keitel, Martin Burdelski, Ulrich Warskulat, Thomas Kühlkamp, Dietrich Keppler, Dieter Häussinger, and Ralf Kubitz
Hepatology, 2005, Volume 41, Number 5, Page 1160

Comments (0)

Please log in or register to comment.
Log in