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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Volume 385, Issue 9 (Sep 2004)


Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer

Konstantina Mathioudaki
  • G. Papanicolaou Research Center of Oncology, ‘Saint Savas’ Hospital, GR-11522 Athens, Greece
/ Andreas Scorilas
  • Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens GR-15711 Athens, Greece
/ Alexandra Papadokostopoulou
  • Department of Gastroenterology, ‘Saint Savas’ Hospital, GR-11522 Athens, Greece
/ Dimitrios Xynopoulos
  • Department of Gastroenterology, ‘Saint Savas’ Hospital, GR-11522 Athens, Greece
/ Niki Arnogianaki
  • Department of Pathology, ‘Saint Savas’ Hospital, GR-11522 Athens, Greece
/ Niki Agnanti
  • Department of Pathology, Medical School, University of Ioannina, GR-45110, Greece
/ Maroulio Talieri
  • G. Papanicolaou Research Center of Oncology, ‘Saint Savas’ Hospital, GR-11522 Athens, Greece
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2004.101


Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RT-PCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes’ stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression.

Keywords: apoptosis; BCL2L12; colon cancer


About the article

Received: February 17, 2004

Accepted: June 29, 2004

Published Online: 2005-06-01

Published in Print: 2004-09-01

Citation Information: Biological Chemistry, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2004.101. Export Citation

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