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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
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Volume 386, Issue 2 (Feb 2005)

Issues

Ceramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner

Helen E. Townley
  • Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
/ Kerrie McDonald
  • Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
/ Gareth I. Jenkins
  • Plant Molecular Science Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, Bower Building, University of Glasgow, Glasgow GL12 8QQ, UK
/ Marc R. Knight
  • Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
/ Christopher J. Leaver
  • Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/BC.2005.020

Abstract

While the role of C2-ceramide in the induction of programmed cell death (PCD) in animal systems has been well documented, little is known of its role in plant cells. Here we show that C2-ceramide induces PCD in Arabidopsis suspension cultures, which is preceded by the generation of a calcium transient and an increase in reactive oxygen species (ROS). Inhibition of the calcium transient prevented cell death, whereas inhibition of ROS had no effect on cell survival. These observations suggest that calcium signalling plays a role in ceramide-induced PCD but is independent of the generation of ROS.

Keywords: apoptosis; calcium signalling; reactive oxygen species

About the article

These authors contributed equally to this work; Corresponding author


Received: October 18, 2004

Accepted: December 17, 2004

Published Online: 2005-06-01

Published in Print: 2005-02-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2005.020.

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