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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 386, Issue 6


Characterisation of human histone H1x

Nicole Happel
  • Institute for Biochemistry and Molecular Cell Biology, University of Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ekkehard Schulze
  • Institute for Biology III, Bioinformatics and Molecular Genetics, Albert-Ludwigs-University, Schaenzlestrasse 1, D-79104 Freiburg, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Detlef Doenecke
  • Institute for Biochemistry and Molecular Cell Biology, University of Göttingen, Humboldtallee 23, D-37073 Göttingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2005-07-07 | DOI: https://doi.org/10.1515/BC.2005.064


The members of the H1 histone family can be classified into three groups, which are the main class subtypes expressed in somatic cells, the developmental- and tissue-specific subtypes, and the replacement subtype H1°. Until now, the subtype H1x was not classified, since it has not yet been thoroughly examined. The results of this study show that H1x shares similarities but also exhibits slight differences in its biochemical behaviour in comparison to the main class H1 histones. In HeLa cells it is located in the nucleus and partially associated with nucleosomes. Nevertheless, it is, like H1°, mainly located in chromatin regions that are not affected by micrococcal nuclease digestion. Further common features of H1x and the replacement histone H1° are that the genes of both subtypes are solitarily located and give rise to polyadenylated mRNA. However, comparison of the inducibility of their expression revealed that their genes are regulated differentially.

Keywords: chromatin; histone gene regulation; histone H1 subtype; sequence comparison

About the article

Corresponding author

Received: January 11, 2005

Accepted: April 25, 2005

Published Online: 2005-07-07

Published in Print: 2005-06-01

Citation Information: Biological Chemistry, Volume 386, Issue 6, Pages 541–551, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2005.064.

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