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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

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Volume 386, Issue 8 (Aug 2005)


Splicing of a rare class of introns by the U12-dependent spliceosome

Cindy L. Will
  • Max Planck Institute for Biophysical Chemistry, Department of Cellular Biochemistry, Am Fassberg 11, D-37077 Göttingen, Germany
/ Reinhard Lührmann
  • Max Planck Institute for Biophysical Chemistry, Department of Cellular Biochemistry, Am Fassberg 11, D-37077 Göttingen, Germany
Published Online: 2005-09-06 | DOI: https://doi.org/10.1515/BC.2005.084


Pre-mRNA splicing is catalyzed by two unique spliceosomes, designated U2- or U12-dependent. In contrast to the well-characterized U2-dependent spliceosome, much remains to be learned about the less abundant U12-type spliceosome. This review focuses on recent advances in elucidating the structure and function of the minor U12-dependent spliceosome. Interesting similarities and differences between the U12- and U2-dependent spliceosomes are also highlighted.

Keywords: pre-mRNA splicing; U11/U12 snRNP; U12-dependent spliceosome


About the article

Corresponding author

Published Online: 2005-09-06

Published in Print: 2005-08-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2005.084. Export Citation

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