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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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Volume 386, Issue 9


Improving the levels of essential amino acids and sulfur metabolites in plants

Gad Galili / Rachel Amir
  • Plant Science Laboratory, Migal – Galilee Technology Centre, P.O. Box 831, Kiryat Shmona 11016, Israel
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/ Rainer Hoefgen
  • Department of Molecular Physiology, Max Plank Institute for Molecular Physiology, Am Mühlenberg 1, D-14476 Golm, Germany
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/ Holger Hesse
  • Department of Molecular Physiology, Max Plank Institute for Molecular Physiology, Am Mühlenberg 1, D-14476 Golm, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2005-09-09 | DOI: https://doi.org/10.1515/BC.2005.097


Plants represent the major source of food for humans, either directly or indirectly through their use as livestock feeds. Plant foods are not nutritionally balanced because they contain low proportions of a number of essential metabolites, such as vitamins and amino acids, which humans and a significant proportion of their livestock cannot produce on their own. Among the essential amino acids needed in human diets, Lys, Met, Thr and Trp are considered as the most important because they are present in only low levels in plant foods. In the present review, we discuss approaches to improve the levels of the essential amino acids Lys and Met, as well as of sulfur metabolites, in plants using metabolic engineering approaches. We also focus on specific examples for which a deeper understanding of the regulation of metabolic networks in plants is needed for tailor-made improvements of amino acid metabolism with minimal interference in plant growth and productivity.

Keywords: cysteine; essential amino acids; lysine; metabolic engineering; methionine; nutritional quality


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Published Online: 2005-09-09

Published in Print: 2005-09-01

Citation Information: Biological Chemistry, Volume 386, Issue 9, Pages 817–831, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2005.097.

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