Jump to ContentJump to Main Navigation
Show Summary Details

Buchner, Johannes

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred


SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

Online
ISSN
1437-4315
See all formats and pricing

 


 
 

Select Volume and Issue

Issues

30,00 € / $42.00 / £23.00

Get Access to Full Text

Glutathione peroxidases and redox-regulated transcription factors

Regina Brigelius-Flohé1

1.

Citation Information: Biological Chemistry. Volume 387, Issue 10/11, Pages 1329–1335, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.166, November 2006

Publication History

Published Online:
2006-11-02

Abstract

Analysis of the selenoproteome identified five glutathione peroxidases (GPxs) in mammals: cytosolic GPx (cGPx, GPx1), phospholipid hydroperoxide GPx (PHGPX, GPx4), plasma GPx (pGPX, GPx3), gastrointestinal GPx (GI-GPx, GPx2) and, in humans, GPx6, which is restricted to the olfactory system. GPxs reduce hydroperoxides to the corresponding alcohols by means of glutathione (GSH). They have long been considered to only act as antioxidant enzymes. Increasing evidence, however, suggests that nature has not created redundant GPxs just to detoxify hydroperoxides. cGPx clearly acts as an antioxidant, as convincingly demonstrated in GPx1-knockout mice. PHGPx specifically interferes with NF-κB activation by interleukin-1, reduces leukotriene and prostanoid biosynthesis, prevents COX-2 expression, and is indispensable for sperm maturation and embryogenesis. GI-GPx, which is not exclusively expressed in the gastrointestinal system, is upregulated in colon and skin cancers and in certain cultured cancer cells. GI-GPx is a target for Nrf2, and thus is part of the adaptive response by itself, while PHGPx might prevent cancer by interfering with inflammatory pathways. In conclusion, cGPx, PHGPx and GI-GPx have distinct roles, particularly in cellular defence mechanisms. Redox sensing and redox regulation of metabolic events have become attractive paradigms to unravel the specific and in part still enigmatic roles of GPxs.

Keywords: cancer; glutathione peroxidases; inflammation; NF-κB; Nrf2

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Juliane Hrdina, Antje Banning, Anna Kipp, Gunnar Loh, Michael Blaut, and Regina Brigelius-Flohé
The Journal of Nutritional Biochemistry, 2009, Volume 20, Number 8, Page 638
[2]
María Luisa Ojeda, Rui Manuel Rua, María Luisa Murillo, Olimpia Carreras, and Fátima Nogales
Alcoholism: Clinical and Experimental Research, 2015, Volume 39, Number 5, Page 818
[3]
Frank Wagener, Carine Carels, and Ditte Lundvig
International Journal of Molecular Sciences, 2013, Volume 14, Number 5, Page 9126
[6]
Karick Jotty, M. Luisa Ojeda, Fátima Nogales, M. Luisa Murillo, and Olimpia Carreras
Alcohol, 2013, Volume 47, Number 7, Page 545
[7]
G. K. Sakellariou, M. J. Jackson, and A. Vasilaki
Free Radical Research, 2014, Volume 48, Number 1, Page 12
[8]
Xinhui Wang, Jun-Won Yun, and Xin Gen Lei
Antioxidants & Redox Signaling, 2014, Volume 20, Number 2, Page 191
[9]
Stephanie M. Barayuga, Xiaosha Pang, Marilou A. Andres, Jun Panee, and Frederick P. Bellinger
NeuroToxicology, 2013, Volume 37, Page 240
[10]
Yiping Qu, Siwen Dang, and Peng Hou
Clinica Chimica Acta, 2013, Volume 424, Page 53
[11]
Esther Humann-Ziehank, Kostja Renko, Michael L. Bruegmann, Vemuri Rama Devi, Marion Hewicker-Trautwein, Arnim Andreae, and Martin Ganter
Journal of Trace Elements in Medicine and Biology, 2013, Volume 27, Number 4, Page 391
[12]
Lilach Ashkenazi and Abraham Haim
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2013, Volume 165, Number 3, Page 353
[13]
Xiao-Fei Xia, Jin-Jing Zheng, Guang-Ming Shao, Jia-Lin Wang, Xu-Sheng Liu, and Yu-Feng Wang
Fish & Shellfish Immunology, 2013, Volume 34, Number 6, Page 1587
[14]
Selcuk Yatmaz, Huei Jiunn Seow, Rosa C. Gualano, Zi Xin Wong, John Stambas, Stavros Selemidis, Peter J. Crack, Steven Bozinovski, Gary P. Anderson, and Ross Vlahos
American Journal of Respiratory Cell and Molecular Biology, 2013, Volume 48, Number 1, Page 17
[15]
Mohammad Ali Foroughi, Hesam Dehghani, Naser Mahdavi-Shahri, and Mohammad Reza Bassami
Journal of Trace Elements in Medicine and Biology, 2013, Volume 27, Number 3, Page 213
[16]
Toru Sasaki, Shoichi Tahara, Tadashi Shinkai, Kazunao Kuramoto, Shigenobu Matsumoto, Makoto Yanabe, Shohei Takagi, Hiroshi Kondo, and Takao Kaneko
Experimental Gerontology, 2013, Volume 48, Number 5, Page 457
[17]
Fabrice Berrué, Malcolm W. B. McCulloch, Patricia Boland, Saskia Hart, Mary Kay Harper, James Johnston, and Russell Kerr
Journal of Natural Products, 2012, Volume 75, Number 12, Page 2094
[19]
Ying Chen, David C. Thompson, Vindhya Koppaka, James V. Jester, and Vasilis Vasiliou
Progress in Retinal and Eye Research, 2013, Volume 33, Page 28
[20]
A.P.P. Zemolin, D.F. Meinerz, M.T. de Paula, D.O.C. Mariano, J.B.T. Rocha, A.B. Pereira, T. Posser, and J.L. Franco
Toxicology, 2012, Volume 302, Number 1, Page 60
[21]
Bruna Fernandes Azevedo, Lorena Barros Furieri, Franck Maciel Peçanha, Giulia Alessandra Wiggers, Paula Frizera Vassallo, Maylla Ronacher Simões, Jonaina Fiorim, Priscila Rossi de Batista, Mirian Fioresi, Luciana Rossoni, Ivanita Stefanon, María Jesus Alonso, Mercedes Salaices, and Dalton Valentim Vassallo
Journal of Biomedicine and Biotechnology, 2012, Volume 2012, Page 1
[22]
U. Subudhi and G. B. N. Chainy
Molecular Biology Reports, 2012, Volume 39, Number 11, Page 9849
[23]
Ebrahim Eftekhar, Athie Hajirahimkhan, Ali Taghizadeh Afshari, and Jaffar Nourooz-Zadeh
Renal Failure, 2012, Volume 34, Number 5, Page 628
[24]
Akira Murakami and Kohta Ohnishi
Food & Function, 2012, Volume 3, Number 5, Page 462
[25]
Caroline M. Woolston, Ahmad Al-Attar, Sarah J. Storr, Ian O. Ellis, David A.L. Morgan, and Stewart G. Martin
International Journal of Radiation Oncology*Biology*Physics, 2011, Volume 79, Number 5, Page 1532
[26]
G. Gong, C. Méplan, H. Gautrey, J. Hall, and J. E. Hesketh
Genes & Nutrition, 2012, Volume 7, Number 2, Page 167
[27]
Marina V. Kasaikina, Dolph L. Hatfield, and Vadim N. Gladyshev
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012, Volume 1823, Number 9, Page 1633
[28]
Alicja Winczura, Daria Zdżalik, and Barbara Tudek
Free Radical Research, 2012, Volume 46, Number 4, Page 442
[29]
Hannah Gautrey, Fergus Nicol, Alan A. Sneddon, Judith Hall, and John Hesketh
Biochimica et Biophysica Acta (BBA) - General Subjects, 2011, Volume 1810, Number 6, Page 284
[30]
Volodymyr I. Lushchak
Journal of Amino Acids, 2012, Volume 2012, Page 1
[31]
Lu Wang, Sean M. Harris, Herbert M. Espinoza, Valerie McClain, and Evan P. Gallagher
Aquatic Toxicology, 2012, Volume 114-115, Page 134
[32]
Ľubomíra Grešáková, Radka Bořutová, Štefan Faix, Iveta Plachá, Klaudia Čobanová, Božena Košíková, and Ľubomír Leng
Acta Veterinaria Hungarica, 2012, Volume 60, Number 1, Page 103
[33]
Christoph Köhle and Karl Walter Bock
Biochemical Pharmacology, 2007, Volume 73, Number 12, Page 1853
[34]
Lutz Schomburg
Nature Reviews Endocrinology, 2011, Volume 8, Number 3, Page 160
[35]
Ling Gao, Karine Laude, and Hua Cai
Veterinary Clinics of North America: Small Animal Practice, 2008, Volume 38, Number 1, Page 137
[36]
Ying Chen, Gaurav Mehta, and Vasilis Vasiliou
The Ocular Surface, 2009, Volume 7, Number 4, Page 176
[37]
Hiroyuki Tsukagoshi, Mamoru Koketsu, Masahiko Kato, Masahiko Kurabayashi, Atsuyoshi Nishina, and Hirokazu Kimura
FEBS Journal, 2007, Volume 274, Number 23, Page 6046
[38]
Stephan Roth, SiJie Zhang, Jazmin Chiu, Eva K Wirth, and Ulrich Schweizer
Journal of Trace Elements in Medicine and Biology, 2010, Volume 24, Number 2, Page 130
[39]
A. J. Montero, C. M. Diaz-Montero, Y. E. Deutsch, J. Hurley, L. G. Koniaris, T. Rumboldt, S. Yasir, M. Jorda, E. Garret-Mayer, E. Avisar, J. Slingerland, O. Silva, C. Welsh, K. Schuhwerk, P. Seo, M. D. Pegram, and S. Glück
Breast Cancer Research and Treatment, 2012, Volume 132, Number 1, Page 215
[40]
Chiemi Tanaka, Donald E. Coling, Senthilvelan Manohar, Guang-Di Chen, Bo Hua Hu, Richard Salvi, and Donald Henderson
Neurobiology of Aging, 2012, Volume 33, Number 8, Page 1842.e1
[41]
A.C. Pappas, E. Zoidis, P.F. Surai, and G. Zervas
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008, Volume 151, Number 4, Page 361
[42]
Hee Joong Lee, Jin Hwan Do, Sumi Bae, Sanghwa Yang, Xianglon Zhang, Ahwon Lee, Young Jin Choi, Dong Choon Park, and Woong Shick Ahn
Medical Oncology, 2011, Volume 28, Number S1, Page 522
[43]
Marcelo Farina, Michael Aschner, and João B.T. Rocha
Toxicology and Applied Pharmacology, 2011, Volume 256, Number 3, Page 405
[44]
Henrike M. Hamer, Daisy M.A.E. Jonkers, Aalt Bast, Steven A.L.W. Vanhoutvin, Marc A.J.G. Fischer, Andrea Kodde, Freddy J. Troost, Koen Venema, and Robert-Jan M. Brummer
Clinical Nutrition, 2009, Volume 28, Number 1, Page 88
[45]
S.L. Aitken, E.L. Karcher, P. Rezamand, J.C. Gandy, M.J. VandeHaar, A.V. Capuco, and L.M. Sordillo
Journal of Dairy Science, 2009, Volume 92, Number 2, Page 589
[46]
Tzung-Han Chou, Hsiou-Yu Ding, Leong-Perng Chan, Jing-Yao Liang, and Chia-Hua Liang
Food Research International, 2011, Volume 44, Number 5, Page 1496
[47]
Christina L. Takanishi, Li-Hua Ma, and Matthew J. Wood
Biochemical and Biophysical Research Communications, 2010, Volume 403, Number 1, Page 46
[48]
Yu-I Li, Gary Elmer, and Renée C. LeBoeuf
Life Sciences, 2008, Volume 83, Number 15-16, Page 557
[49]
Véronique Vacchina, Marc Moutet, Jean-Claude Yadan, Frédéric de Baene, Bernard Kudla, and Ryszard Lobinski
Journal of Chromatography B, 2010, Volume 878, Number 15-16, Page 1178
[50]
Denise Grotto, Juliana Valentini, Myriam Fillion, Carlos José Souza Passos, Solange Cristina Garcia, Donna Mergler, and Fernando Barbosa
Science of The Total Environment, 2010, Volume 408, Number 4, Page 806
[51]
Enrique Herrero, Joaquim Ros, Gemma Bellí, and Elisa Cabiscol
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008, Volume 1780, Number 11, Page 1217
[52]
Pin Zhuo and Alan M. Diamond
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009, Volume 1790, Number 11, Page 1546
[53]
Jaya Chilakapati, Kathleen Wallace, Hongzu Ren, Michael Fricke, Kathryn Bailey, William Ward, Jack Creed, and Kirk Kitchin
Toxicology, 2010, Volume 268, Number 1-2, Page 31
[54]
Wieslawa Kosinska, Michael Khmelnitsky, Jung Hyun Kim, Zhong-Lin Zhao, and Joseph B. Guttenplan
Environmental and Molecular Mutagenesis, 2011, Volume 52, Number 6, Page 502
[55]
Satori A Marchitti, Ying Chen, David C Thompson, and Vasilis Vasiliou
Eye & Contact Lens: Science & Clinical Practice, 2011, Volume 37, Number 4, Page 206
[56]
S. Ferguson, B. Mouzon, G. Kayihan, M. Wood, F. Poon, S. Doore, V. Mathura, J. Humphrey, B. O'Steen, R. Hayes, A. Roses, M. Mullan, and F. Crawford
Neuroscience, 2010, Volume 168, Number 3, Page 811
[57]
Margaret S. Lee, Mina Yaar, Mark S. Eller, Thomas M. Rünger, Ying Gao, and Barbara A. Gilchrest
Journal of Dermatological Science, 2009, Volume 56, Number 3, Page 154
[58]
Yury G. Kaminsky, Michael W. Marlatt, Mark A. Smith, and Elena A. Kosenko
Experimental Neurology, 2010, Volume 221, Number 1, Page 26
[59]
Guang-Zhao Li, Xu-Fang Liang, Wei Yao, Wan-Qin Liao, and Wei-Feng Zhu
BMB Reports, 2008, Volume 41, Number 3, Page 204
[60]
Jeferson L. Franco, Thaís Posser, Peter R. Dunkley, Phillip W. Dickson, Jacó J. Mattos, Roberta Martins, Afonso C.D. Bainy, Maria R. Marques, Alcir L. Dafre, and Marcelo Farina
Free Radical Biology and Medicine, 2009, Volume 47, Number 4, Page 449
[61]
Alena Svobodová and Jitka Vostálová
International Journal of Radiation Biology, 2010, Volume 86, Number 12, Page 999
[62]
M. Vinceti, T. Maraldi, M. Bergomi, and C. Malagoli
Reviews on Environmental Health, 2009, Volume 24, Number 3
[63]
Min-Hyuk Yoo, Xinglong Gu, Xue-Ming Xu, Jin-Young Kim, Bradley A. Carlson, Andrew D. Patterson, Huaibin Cai, Vadim N. Gladyshev, and Dolph L. Hatfield
Antioxidants & Redox Signaling, 2010, Volume 12, Number 7, Page 819
[64]
Catherine Méplan, Fergus Nicol, Brian T. Burtle, Lynne K. Crosley, John R. Arthur, John C. Mathers, and John E. Hesketh
Antioxidants & Redox Signaling, 2009, Volume 11, Number 11, Page 2631
[65]
[66]
Anna Kipp, Antje Banning, and Regina Brigelius-Flohé
Biological Chemistry, 2007, Volume 388, Number 10
[67]
Peggy Jungke, Gigi Ostrow, Jian-Liang Li, Sharon Norton, Karen Nieber, Olaf Kelber, and Veronika Butterweck
Psychopharmacology, 2011, Volume 213, Number 4, Page 757
[68]
Vanja Radišić Biljak, Lada Rumora, Ivana Čepelak, Dolores Pancirov, Sanja Popović-Grle, Jasna Sorić, and Tihana Žanić Grubišić
Cell Biochemistry and Function, 2010, Volume 28, Number 6, Page 448
[69]
Alison Sutherland, Dong-Hyun Kim, Caroline Relton, Yoon-Ok Ahn, and John Hesketh
Genes & Nutrition, 2010, Volume 5, Number 3, Page 215
[70]
V. I. Kulinsky and L. S. Kolesnichenko
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2010, Volume 4, Number 3, Page 224
[71]
Wayne Chris Hawkes and Zeynep Alkan
Biological Trace Element Research, 2010, Volume 134, Number 3, Page 235
[72]
Sarah Elizabeth Jackson-Rosario and William Thomas Self
Metallomics, 2010, Volume 2, Number 2, Page 112
[73]
I. Placha, R. Borutova, L. Gresakova, V. Petrovic, S. Faix, and L. Leng
Journal of Animal Physiology and Animal Nutrition, 2009, Volume 93, Number 6, Page 695
[74]
V. I. Kulinsky and L. S. Kolesnichenko
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2009, Volume 3, Number 2, Page 129
[75]
A. T. Grazul-Bilska, J. J. Bilski, D. A. Redmer, L. P. Reynolds, K. M. Abdullah, and A. Abdullah
International Journal of Cosmetic Science, 2009, Volume 31, Number 3, Page 201
[76]
G. A. Behr, L. L. da Motta, M. R. de Oliveira, M. W. S. Oliveira, D. P. Gelain, and J. C. F. Moreira
Chemical Senses, 2009, Volume 34, Number 4, Page 317
[77]
Ioannis G. Habeos, Panos G. Ziros, Dionysios Chartoumpekis, Agathoklis Psyrogiannis, Venetsana Kyriazopoulou, and Athanasios G. Papavassiliou
Journal of Molecular Medicine, 2008, Volume 86, Number 11, Page 1279
[78]
Harsharn GILL and Glen WALKER
Nutrition & Dietetics, 2008, Volume 65, Page S41
[79]
Margaret P. Rayman
British Journal of Nutrition, 2008, Volume 100, Number 02
[80]
Philip Rosenstiel and Stefan Schreiber
European Journal of Gastroenterology & Hepatology, 2008, Volume 20, Number 6, Page 496
[81]
Albena T. Dinkova-Kostova and Paul Talalay
Molecular Nutrition & Food Research, 2008
[82]
Yue Ge, R. Julian Preston, and Russell D. Owen
PROTEOMICS – CLINICAL APPLICATIONS, 2007, Volume 1, Number 12, Page 1613

Comments (0)

Please log in or register to comment.