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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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1437-4315
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The l-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function

Tienush Rassaf
  • University Hospital Aachen, Medical Clinic I, Department of Medicine, Division of Cardiology and Pulmonary Diseases, D-52074 Aachen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Petra Kleinbongard
  • University Hospital Aachen, Medical Clinic I, Department of Medicine, Division of Cardiology and Pulmonary Diseases, D-52074 Aachen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Malte Kelm
  • University Hospital Aachen, Medical Clinic I, Department of Medicine, Division of Cardiology and Pulmonary Diseases, D-52074 Aachen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2006-11-02 | DOI: https://doi.org/10.1515/BC.2006.168

Abstract

Endothelial dysfunction is an early stage of atherosclerosis and has been attributed to impaired nitric oxide (NO) bioactivity and enhanced formation of oxygen-derived free radicals. Given that endothelial dysfunction is at least in part reversible, the assessment of altered NO availability is of important diagnostic and prognostic significance. Identification of such alterations may help to target asymptomatic individuals who are at risk for cardiovascular diseases and would likely benefit from preventive measures. Focusing on a single signaling pathway, we present here a multi-level approach for the early diagnosis of cardiovascular diseases by assessing molecular, biochemical, structural, and functional changes in the vascular wall.

Keywords: biomarker; endothelial dysfunction; endothelium; nitrite; NOS

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Corresponding author


Published Online: 2006-11-02

Published in Print: 2006-10-01


Citation Information: Biological Chemistry, Volume 387, Issue 10/11, Pages 1347–1349, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.168.

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