Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

See all formats and pricing
More options …
Just Accepted


Protein oxidation and proteolysis

Nicolle Bader
  • Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, D-70593 Stuttgart, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Tilman Grune
  • Institute of Biological Chemistry and Nutrition, University of Hohenheim, Garbenstraße 28, D-70593 Stuttgart, Germany and Research Institute of Enviromental Medicine, Heinrich Heine University Düsseldorf, Auf'm Hennekamp 50, D-40225 Düsseldorf, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2006-11-02 | DOI: https://doi.org/10.1515/BC.2006.169


One of the hallmarks of chronic or severe oxidative stress is the accumulation of oxidized proteins, which tend to form high-molecular-weight aggregates. The major proteolytic system responsible for the removal of oxidized cytosolic and nuclear proteins is the proteasome. This complicated proteolytic system contains a core proteasomal form (20S proteasome) and several regulators. All of these components are affected by oxidative stress to various degrees. The ATP-stimulated 26S proteasome is sensitive to oxidative stress, whereas the 20S form seems to be more resistant. The nuclear proteasome selectively degrades oxidatively damaged histones in the nuclei of mammalian cells, where it is activated and regulated by automodified PARP-1 after oxidative challenge. In this brief review we highlight the proteolysis and its regulatory effects during oxidative stress.

Keywords: oxidative stress; PARP; proteasome; protein oxidation; ubiquitination

About the article

Corresponding author ;

Published Online: 2006-11-02

Published in Print: 2006-10-01

Citation Information: Biological Chemistry, Volume 387, Issue 10/11, Pages 1351–1355, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.169.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Todd M. Umstead, Willard M. Freeman, Vernon M. Chinchilli, and David S. Phelps
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2009, Volume 296, Number 1, Page L14
Michael Liebthal, Daniel Maynard, and Karl-Josef Dietz
Antioxidants & Redox Signaling, 2017
Christine Vogel, Gustavo Monteiro Silva, and Edward M. Marcotte
Molecular & Cellular Proteomics, 2011, Volume 10, Number 12, Page M111.009217
Sandra Barth, Frank Edlich, Utta Berchner-Pfannschmidt, Silke Gneuss, Günther Jahreis, Philippe A. Hasgall, Joachim Fandrey, Roland H. Wenger, and Gieri Camenisch
Journal of Biological Chemistry, 2009, Volume 284, Number 34, Page 23046
Qiaoli Ma, Junmei Kang, Ruicai Long, Tiejun Zhang, Junbo Xiong, Kun Zhang, Tenghua Wang, Qingchuan Yang, and Yan Sun
Molecular Biology Reports, 2017, Volume 44, Number 3, Page 261
Junjun Zhao, Shuqing Yu, Yan Zheng, Hui Yang, and Jianliang Zhang
Molecular Neurobiology, 2017, Volume 54, Number 2, Page 1404
R. Mancinelli, H. Kern, S. Fulle, U. Carraro, S. Zampieri, R. La Rovere, G. Fanò, and T. Pietrangelo
International Journal of Immunopathology and Pharmacology, 2011, Volume 24, Number 3, Page 749
Andrea Iorga, Shannamar Dewey, Rod Partow-Navid, Aldrin V. Gomes, Mansoureh Eghbali, and Yao Liang Tang
PLoS ONE, 2012, Volume 7, Number 11, Page e48601
Gulce Sari Kaplan, Ceyda Corek Torcun, Tilman Grune, Nesrin Kartal Ozer, and Betul Karademir
Free Radical Biology and Medicine, 2017, Volume 103, Page 1
Pedro Fernandez-Funez, Jonatan Sanchez-Garcia, Lorena de Mena, Yan Zhang, Yona Levites, Swati Khare, Todd E. Golde, and Diego E. Rincon-Limas
Proceedings of the National Academy of Sciences, 2016, Volume 113, Number 35, Page E5212
Ana Caroline F. Santos, Fabiana A. Moura, Auro A. Tanaka, Rita C. S. Luz, Flavio S. Damos, Lauro T. Kubota, and Marilia O. F. Goulart
Electroanalysis, 2016, Volume 28, Number 11, Page 2818
Aria Babakhani, K. H. Sabeena Farvin, and Charlotte Jacobsen
Food and Bioprocess Technology, 2016, Volume 9, Number 2, Page 352
Jasmina Kurepa, Songhu Wang, Yan Li, and Jan Smalle
Plant Signaling & Behavior, 2009, Volume 4, Number 10, Page 924
Ashley J. Smuder, W. Bradley Nelson, Matthew B. Hudson, Andreas N. Kavazis, and Scott K. Powers
Anesthesiology, 2014, Volume 121, Number 1, Page 115
Nurit Livnat-Levanon, Éva Kevei, Oded Kleifeld, Daria Krutauz, Alexandra Segref, Teresa Rinaldi, Zoi Erpapazoglou, Mickael Cohen, Noa Reis, Thorsten Hoppe, and Michael H. Glickman
Cell Reports, 2014, Volume 7, Number 5, Page 1371
Salomé Adam and Sophie E. Polo
International Journal of Molecular Sciences, 2012, Volume 13, Number 12, Page 11895
Daniela Knoefler, Maike Thamsen, Martin Koniczek, Nicholas J. Niemuth, Ann-Kristin Diederich, and Ursula Jakob
Molecular Cell, 2012, Volume 47, Number 5, Page 767
Gaston Soria, Sophie E. Polo, and Geneviève Almouzni
Molecular Cell, 2012, Volume 46, Number 6, Page 722
Christoph J. Heuck and John D. Shaughnessy
Seminars in Hematology, 2012, Volume 49, Number 3, Page 193
Tobias Jung, Nicolle Bader, and Tilman Grune
Archives of Biochemistry and Biophysics, 2007, Volume 462, Number 2, Page 231
Tobias Jung, Annika Höhn, Betul Catalgol, and Tilman Grune
Archives of Biochemistry and Biophysics, 2009, Volume 483, Number 1, Page 127
Anke Böhmer, Henning Großkopf, Jens Jordan, and Dimitrios Tsikas
Nitric Oxide, 2012, Volume 27, Number 1, Page 72
Laura Bonfili, Valentina Cecarini, Manila Amici, Massimiliano Cuccioloni, Mauro Angeletti, Jeffrey N. Keller, and Anna M. Eleuteri
FEBS Journal, 2008, Volume 275, Number 22, Page 5512
Soo-Ung Lee, Migyo Joung, Taekyoung Nam, Woo-Yoon Park, Young-Hoon Ji, and Jae-Ran Yu
Experimental Parasitology, 2011, Volume 127, Number 1, Page 25
Tae Ho Lee, Lucia Pastorino, and Kun Ping Lu
Expert Reviews in Molecular Medicine, 2011, Volume 13
Gerard F. Powell, Deborah A. Ward, Mark C. Prescott, David G. Spiller, Michael R.H. White, Phillip C. Turner, Fergus G.P. Earley, Janet Phillips, and Huw H. Rees
Insect Biochemistry and Molecular Biology, 2011, Volume 41, Number 7, Page 459
Ivan Couée and Françoise Bringel
Journal of Theoretical Biology, 2010, Volume 266, Number 3, Page 479
Hamid Mirzaei and Fred Regnier
Journal of Chromatography B, 2008, Volume 873, Number 1, Page 8
Emmanuel Roger, Guillaume Mitta, Yves Moné, Anne Bouchut, Anne Rognon, Christoph Grunau, Jérôme Boissier, André Théron, and Benjamin E.F. Gourbal
Molecular and Biochemical Parasitology, 2008, Volume 157, Number 2, Page 205
Jasmina Kurepa and Jan A. Smalle
Biochimie, 2008, Volume 90, Number 2, Page 324
Aurélien Bayot, Nicolas Basse, Irene Lee, Monique Gareil, Bernard Pirotte, Anne-Laure Bulteau, Bertrand Friguet, and Michèle Reboud-Ravaux
Biochimie, 2008, Volume 90, Number 2, Page 260
Howard M. Kipen, Sampada Gandhi, David Q. Rich, Pamela Ohman-Strickland, Robert Laumbach, Zhi-Hua Fan, Li Chen, Debra L. Laskin, Junfeng Zhang, and Kiran Madura
Environmental Health Perspectives, 2010, Volume 119, Number 5, Page 658
Isabelle Jariel-Encontre, Guillaume Bossis, and Marc Piechaczyk
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2008, Volume 1786, Number 2, Page 153
Nurit Livnat-Levanon and Michael H. Glickman
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011, Volume 1809, Number 2, Page 80
Stefanie Grimm, Dagmar Mvondo, Tilman Grune, and Nicolle Breusing
BioFactors, 2011, Volume 37, Number 1, Page 17
I. Imbert, C. Gondran, G. Oberto, K. Cucumel, C. Dal Farra, and N. Domloge
International Journal of Cosmetic Science, 2010, Volume 32, Number 6, Page 446
Tilman Grune and Mette M Berger
Current Opinion in Clinical Nutrition and Metabolic Care, 2007, Volume 10, Number 6, Page 712
Peter G Arthur, Miranda D Grounds, and Thea Shavlakadze
Current Opinion in Clinical Nutrition and Metabolic Care, 2008, Volume 11, Number 4, Page 408
Rukhsana Sultana and D. Allan Butterfield
PROTEOMICS – CLINICAL APPLICATIONS, 2008, Volume 2, Number 5, Page 685
Mac B. Robinson, Anna R. Taylor, David J. Gifondorwa, Michael Tytell, and Carolanne E. Milligan
Developmental Neurobiology, 2008, Volume 68, Number 1, Page 1
Xianglan Yao, Jiong Liu, and Joseph T. McCabe
Journal of Neurochemistry, 2007, Volume 0, Number 0, Page 071018045431003
Manfred Sommer and Gunter Wolf
American Journal of Nephrology, 2007, Volume 27, Number 4, Page 425

Comments (0)

Please log in or register to comment.
Log in