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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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1437-4315
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Air pollution-associated fly ash particles induce fibrotic mechanisms in primary fibroblasts

Torsten Gursinsky
  • Department of Cardiothoracic Surgery, University of Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120 Halle, Germany
  • Other articles by this author:
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/ Stefanie Ruhs
  • Department of Cardiothoracic Surgery, University of Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120 Halle, Germany
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/ Ulrich Friess
  • Internal Medicine IV, University of Tübingen, Ottfried-Müller-Str. 10, D-72076 Tübingen, Germany
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/ Silvia Diabaté
  • Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Weberstr. 5, D-76133 Karlsruhe, Germany
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/ Harald F. Krug
  • Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Weberstr. 5, D-76133 Karlsruhe, Germany
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/ Rolf-Edgar Silber
  • Department of Cardiothoracic Surgery, University of Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120 Halle, Germany
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/ Andreas Simm
  • Department of Cardiothoracic Surgery, University of Halle-Wittenberg, Ernst-Grube-Str. 40, D-06120 Halle, Germany
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Published Online: 2006-11-02 | DOI: https://doi.org/10.1515/BC.2006.177

Abstract

Air pollution is associated with a variety of respiratory and cardiovascular disorders, including fibrosis. To understand the possible molecular mechanisms underlying this observation, we examined the effect of particulate matter on primary fibroblasts, the key regulators of the extracellular matrix. Fly ash collected in an experimental waste incinerator was used as model particles for fine and ultrafine pollution components. Brief treatment of fibroblasts isolated from adult male Wistar rat hearts with fly ash triggered the immediate formation of intracellular reactive oxygen species (ROS). Using phospho-specific antibodies we observed activation of p38 MAP kinase, p44/42 MAP kinase (ERK1/2) and p70S6 kinase. Prolonged incubation with fly ash increased the expression of collagen 1 and TGF-β1, but decreased mRNA levels of MMP9 and TNF-α. Cell proliferation was inhibited at high concentrations of fly ash. An increase in the level of advanced glycation endproduct (AGE) modification of various cellular proteins after long-term treatment of cultured fibroblasts with fly ash was observed. The results of our study demonstrate that direct activation of fibroblasts by combustion-derived particles is a mechanism that may contribute to the adverse health effects of particulate air pollution.

Keywords: advanced glycation endproducts; extracellular matrix; fibrosis; oxidative stress; particulate matter

About the article

Corresponding author


Received: May 15, 2006

Accepted: July 20, 2006

Published Online: 2006-11-02

Published in Print: 2006-10-01


Citation Information: Biological Chemistry, Volume 387, Issue 10/11, Pages 1411–1420, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.177.

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