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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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Volume 387, Issue 12


Mitochondrial morphology and distribution in mammalian cells

Ann E. Frazier / Clement Kiu / Diana Stojanovski
  • Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia and Present address: Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany
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/ Nicholas J. Hoogenraad / Michael T. Ryan
Published Online: 2006-11-28 | DOI: https://doi.org/10.1515/BC.2006.193


It is now appreciated that mitochondria form tubular networks that adapt to the requirements of the cell by undergoing changes in their shape through fission and fusion. Proper mitochondrial distribution also appears to be required for ATP delivery and calcium regulation, and, in some cases, for cell development. While we now realise the great importance of mitochondria for the cell, we are only beginning to work out how these organelles undergo the drastic morphological changes that are essential for cellular function. Of the few known components involved in shaping mitochondria, some have been found to be essential to life and their gene mutations are linked to neurological disorders, while others appear to be recruited in the activation of cell death pathways. Here we review our current understanding of the functions of the main players involved in mitochondrial fission, fusion and distribution in mammalian cells.

Keywords: apoptosis; cytoskeleton; fission; fusion; mitochondria

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Corresponding author

Published Online: 2006-11-28

Published in Print: 2006-12-01

Citation Information: Biological Chemistry, Volume 387, Issue 12, Pages 1551–1558, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.193.

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