Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing
Volume 387, Issue 12 (Dec 2006)


Mitochondrial morphology and distribution in mammalian cells

Ann E. Frazier
  • Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
/ Clement Kiu
  • Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
/ Diana Stojanovski
  • Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia and Present address: Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany
/ Nicholas J. Hoogenraad
  • Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
/ Michael T. Ryan
  • Department of Biochemistry, La Trobe University, 3086 Melbourne, Australia
Published Online: 2006-11-28 | DOI: https://doi.org/10.1515/BC.2006.193


It is now appreciated that mitochondria form tubular networks that adapt to the requirements of the cell by undergoing changes in their shape through fission and fusion. Proper mitochondrial distribution also appears to be required for ATP delivery and calcium regulation, and, in some cases, for cell development. While we now realise the great importance of mitochondria for the cell, we are only beginning to work out how these organelles undergo the drastic morphological changes that are essential for cellular function. Of the few known components involved in shaping mitochondria, some have been found to be essential to life and their gene mutations are linked to neurological disorders, while others appear to be recruited in the activation of cell death pathways. Here we review our current understanding of the functions of the main players involved in mitochondrial fission, fusion and distribution in mammalian cells.

Keywords: apoptosis; cytoskeleton; fission; fusion; mitochondria


About the article

Corresponding author

Corresponding author

Published Online: 2006-11-28

Published in Print: 2006-12-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.193. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Hee Soon Choi, Hee Jin Kim, Jin-Hwan Oh, Hyeong-Geun Park, Jeong Chan Ra, Keun-A. Chang, and Yoo-Hun Suh
Neurobiology of Aging, 2015
Fan Zhang, Wenzhang Wang, Sandra L. Siedlak, Yingchao Liu, Jun Liu, Keji Jiang, George Perry, Xiongwei Zhu, and Xinglong Wang
Frontiers in Aging Neuroscience, 2015, Volume 7
C. Simoncini, D. Orsucci, E. Caldarazzo Ienco, G. Siciliano, U. Bonuccelli, and M. Mancuso
Oxidative Medicine and Cellular Longevity, 2015, Volume 2015, Page 1
Olga S. Koutsopoulos, David Laine, Laura Osellame, Dmitriy M. Chudakov, Robert G. Parton, Ann E. Frazier, and Michael T. Ryan
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010, Volume 1803, Number 5, Page 564
Thomas E. Gunter and Shey-Shing Sheu
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2009, Volume 1787, Number 11, Page 1291
E. Mendoza, J.A. Miranda-Barrientos, R.A. Vázquez-Roque, E. Morales-Herrera, A. Ruelas, G. De la Rosa, G. Flores, and E. Hernández-Echeagaray
Neuroscience, 2014, Volume 280, Page 156
X. Li, Z. Xu, Z. Jiang, L. Sun, J. Ji, J. Miao, X. Zhang, X. Li, S. Huang, T. Wang, and L. Zhang
Acta Biochimica et Biophysica Sinica, 2014, Volume 46, Number 9, Page 738
Cristiane Benincá, Jesús Planagumà, Adriana de Freitas Shuck, Rebeca Acín-Perez, Juan Pablo Muñoz, Marina Mateus de Almeida, Joan H. Brown, Anne N. Murphy, Antonio Zorzano, Jose Antonio Enríquez, and Anna M. Aragay
Cellular Signalling, 2014, Volume 26, Number 5, Page 1135
Esther Rodríguez-Gallego, Marta Riera-Borrull, Anna Hernández-Aguilera, Roger Mariné-Casadó, Anna Rull, Raúl Beltrán-Debón, Fedra Luciano-Mateo, Javier A. Menendez, Alejandro Vazquez-Martin, Juan J. Sirvent, Vicente Martín-Paredero, Angel L. Corbí, Elena Sierra-Filardi, Gerard Aragonès, Anabel García-Heredia, Jordi Camps, Carlos Alonso-Villaverde, and Jorge Joven
Mediators of Inflammation, 2013, Volume 2013, Page 1
Xueqi Gan, Shengbin Huang, Long Wu, Yongfu Wang, Gang Hu, Guangyue Li, Hongju Zhang, Haiyang Yu, Russell Howard Swerdlow, John Xi Chen, and Shirley ShiDu Yan
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014, Volume 1842, Number 2, Page 220
Vega García-Escudero, Patricia Martín-Maestro, George Perry, and Jesús Avila
Oxidative Medicine and Cellular Longevity, 2013, Volume 2013, Page 1
Martin P Horan, Neil J Gemmell, and Jonci N Wolff
European Journal of Human Genetics, 2013, Volume 21, Number 12, Page 1335
Sung-Ryul Lee, Hyoung-Kyu Kim, In-Sung Song, Jaeboum Youm, Louise Anne Dizon, Seung-Hun Jeong, Tae-Hee Ko, Hye-Jin Heo, Kyoung Soo Ko, Byoung Doo Rhee, Nari Kim, and Jin Han
Progress in Biophysics and Molecular Biology, 2013, Volume 112, Number 1-2, Page 44
Anna Hernández-Aguilera, Anna Rull, Esther Rodríguez-Gallego, Marta Riera-Borrull, Fedra Luciano-Mateo, Jordi Camps, Javier A. Menéndez, and Jorge Joven
Mediators of Inflammation, 2013, Volume 2013, Page 1
Courtney M. Peterson, Darcy L. Johannsen, and Eric Ravussin
Journal of Aging Research, 2012, Volume 2012, Page 1
Katarina Reis, Åsa Fransson, and Pontus Aspenström
FEBS Letters, 2009, Volume 583, Number 9, Page 1391
Stephen H. Caldwell, Luiz Antonio R. de Freitas, Sang H. Park, Maria Lucia V. Moreno, Jan A. Redick, Christine A. Davis, Barbee J. Sisson, James T. Patrie, Helma Cotrim, Curtis K. Argo, and Abdullah Al-Osaimi
Hepatology, 2009, Volume 49, Number 6, Page 1888
Diane E. Handy and Joseph Loscalzo
Antioxidants & Redox Signaling, 2012, Volume 16, Number 11, Page 1323
Oana C. Marina, Claire K. Sanders, and Judith R. Mourant
Biomedical Optics Express, 2012, Volume 3, Number 2, Page 296
Germaine Escames, Luis Carlos López, José Antonio García, Laura García-Corzo, Francisco Ortiz, and Darío Acuña-Castroviejo
Human Genetics, 2012, Volume 131, Number 2, Page 161
George E.N. Kass and Shirley C. Price
Clinics in Liver Disease, 2008, Volume 12, Number 1, Page 27
Xinglong Wang, Bo Su, Hisashi Fujioka, and Xiongwei Zhu
The American Journal of Pathology, 2008, Volume 173, Number 2, Page 470
Massimiliano Filosto, Mauro Scarpelli, Maria Sofia Cotelli, Valentina Vielmi, Alice Todeschini, Valeria Gregorelli, Paola Tonin, Giuliano Tomelleri, and Alessandro Padovani
Journal of Neurology, 2011, Volume 258, Number 10, Page 1763
Giulietta Riboldi, Monica Nizzardo, Chiara Simone, Marianna Falcone, Nereo Bresolin, Giacomo P. Comi, and Stefania Corti
Progress in Neurobiology, 2011, Volume 95, Number 2, Page 133
Ping Shi, Anna-Lena Ström, Jozsef Gal, and Haining Zhu
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010, Volume 1802, Number 9, Page 707
Alexandra Harvey, Tiffini Gibson, Thomas Lonergan, and Carol Brenner
Mitochondrion, 2011, Volume 11, Number 5, Page 829
Catherine S. Palmer, Laura D. Osellame, Diana Stojanovski, and Michael T. Ryan
Cellular Signalling, 2011, Volume 23, Number 10, Page 1534
Andrew B. Noske, Adam J. Costin, Garry P. Morgan, and Brad J. Marsh
Journal of Structural Biology, 2008, Volume 161, Number 3, Page 298
Zara Hannoun, Sebastian Greenhough, Ellis Jaffray, Ronald T. Hay, and David C. Hay
Toxicology, 2010, Volume 278, Number 3, Page 288
Catherine S Palmer, Laura D Osellame, David Laine, Olga S Koutsopoulos, Ann E Frazier, and Michael T Ryan
EMBO reports, 2011, Volume 12, Number 6, Page 565
Anthony E. Civitarese, Paul S. MacLean, Stacy Carling, Lyndal Kerr-Bayles, Ryan P. McMillan, Anson Pierce, Thomas C. Becker, Cedric Moro, Jean Finlayson, Natalie Lefort, Christopher B. Newgard, Lawrence Mandarino, William Cefalu, Ken Walder, Greg R. Collier, Matthew W. Hulver, Steven R. Smith, and Eric Ravussin
Cell Metabolism, 2010, Volume 11, Number 5, Page 412
Michael T. Ryan and Nicholas J. Hoogenraad
Annual Review of Biochemistry, 2007, Volume 76, Number 1, Page 701
Sandra Merz, Miriam Hammermeister, Katrin Altmann, Mark Dürr, and Benedikt Westermann
Biological Chemistry, 2007, Volume 388, Number 9
Bo Su, Xinglong Wang, David Bonda, Gorge Perry, Mark Smith, and Xiongwei Zhu
Molecular Neurobiology, 2010, Volume 41, Number 2-3, Page 87
David J. Bonda, Xinglong Wang, George Perry, Mark A. Smith, and Xiongwei Zhu
Drugs & Aging, 2010, Volume 27, Number 3, Page 181
Xinglong Wang, Bo Su, Ling Zheng, George Perry, Mark A. Smith, and Xiongwei Zhu
Journal of Neurochemistry, 2009, Volume 109, Page 153
Bo Huang, Sara A Jones, Boerries Brandenburg, and Xiaowei Zhuang
Nature Methods, 2008, Volume 5, Number 12, Page 1047
Anna-Lena Strm, Jozsef Gal, Ping Shi, Edward J. Kasarskis, Lawrence J. Hayward, and Haining Zhu
Journal of Neurochemistry, 2008, Volume 106, Number 2, Page 495
Geneviève Morrow and Robert M. Tanguay
Biotechnology Journal, 2008, Volume 3, Number 6, Page 728
Noriko Kondo-Okamoto, Janet M Shaw, and Koji Okamoto
EMBO reports, 2008, Volume 9, Number 1, Page 63
Neil Dixon, Lu Shin Wong, Torsten H. Geerlings, and Jason Micklefield
Natural Product Reports, 2007, Volume 24, Number 6, Page 1288

Comments (0)

Please log in or register to comment.
Log in