Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

See all formats and pricing



Select Volume and Issue


Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)

Nathalie Beaufort1 / Mekdes Debela2 / Sabine Creutzburg3 / Josef Kellermann4 / Wolfram Bode5 / Manfred Schmitt6 / Dominique Pidard7 / Viktor Magdolen8









Corresponding author

Citation Information: Biological Chemistry. Volume 387, Issue 2, Pages 217–222, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2006.029, February 2006

Publication History

August 14, 2005
October 20, 2005
Published Online:


The plasminogen activation system is involved in cancer progression and metastasis. Among other proteolytic factors, it includes the serine protease urokinase-type plasminogen activator (uPA) and its three-domain (D1D2D3) receptor uPAR (CD87), which focuses plasminogen activation to the cell surface. The function of uPAR is regulated in part through shedding of domain D1 by proteases, e.g., uPA itself or plasmin. Human tissue kallikrein 4 (hK4), which is highly expressed in prostate and ovarian tumor tissue, was previously shown to cleave and activate the pro-enzyme forms of prostate-specific antigen (PSA, tissue kallikrein hK3) and uPA. Here we demonstrate that uPAR is also a target for hK4, being cleaved in the D1-D2 linker sequence and, to a lesser extent, in its D3 juxtamembrane domain. hK4 may thus modulate the tumor-associated uPA/uPAR-system activity by either activating the pro-enzyme form of uPA or cleaving the cell surface-associated uPA receptor.

Keywords: enamel matrix serine protease 1; invasion; metastasis; prostase; tumor-associated proteolytic system

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Jeroen van Soom, Giuliana Cuzzucoli Crucitti, Rafaela Gladysz, Pieter van der Veken, Roberto Di Santo, Ingmar Stuyver, Victoria Buck, Anne-Marie Lambeir, Viktor Magdolen, Jurgen Joossens, and Koen Augustyns
Med. Chem. Commun., 2015, Volume 6, Number 11, Page 1954
Vittore Cereda, Vincenzo Formica, Antonello Menghi, Stefania Pellicori, and Mario Roselli
Expert Opinion on Investigational Drugs, 2015, Volume 24, Number 7, Page 929
Konstantinos Mavridis, Margaritis Avgeris, and Andreas Scorilas
Expert Opinion on Therapeutic Targets, 2014, Volume 18, Number 4, Page 365
Julia Dorn, Nathalie Beaufort, Manfred Schmitt, Eleftherios P. Diamandis, Peter Goettig, and Viktor Magdolen
Critical Reviews in Clinical Laboratory Sciences, 2014, Volume 51, Number 2, Page 63
Ying Dong, Daniela Loessner, Helen Irving-Rodgers, Andreas Obermair, James L. Nicklin, and Judith A. Clements
Clinical & Experimental Metastasis, 2014, Volume 31, Number 1, Page 135
Francesco Blasi and Nicolai Sidenius
FEBS Letters, 2010, Volume 584, Number 9, Page 1923
Mekdes Debela, Viktor Magdolen, Valerie Grimminger, Christian Sommerhoff, Albrecht Messerschmidt, Robert Huber, Rainer Friedrich, Wolfram Bode, and Peter Goettig
Journal of Molecular Biology, 2006, Volume 362, Number 5, Page 1094
Georgios Pampalakis and Georgia Sotiropoulou
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2007, Volume 1776, Number 1, Page 22
Nashmil Emami and Eleftherios P. Diamandis
Molecular Oncology, 2007, Volume 1, Number 3, Page 269
Michael Blaber, Hyesook Yoon, Maria A. Juliano, Isobel A. Scarisbrick, and Sachiko I. Blaber
Biological Chemistry, 2010, Volume 391, Number 4
Valérie Gratio, Nathalie Beaufort, Lina Seiz, Josefine Maier, G. Duke Virca, Mekdes Debela, Nicolai Grebenchtchikov, Viktor Magdolen, and Dalila Darmoul
The American Journal of Pathology, 2010, Volume 176, Number 3, Page 1452
Peter Goettig, Viktor Magdolen, and Hans Brandstetter
Biochimie, 2010, Volume 92, Number 11, Page 1546
Joakim E. Swedberg, Laura V. Nigon, Janet C. Reid, Simon J. de Veer, Carina M. Walpole, Carson R. Stephens, Terry P. Walsh, Thomas K. Takayama, John D. Hooper, Judith A. Clements, Ashley M. Buckle, and Jonathan M. Harris
Chemistry & Biology, 2009, Volume 16, Number 6, Page 633
Nathalie Beaufort, Karolina Plaza, Daniel Utzschneider, Amelie Schwarz, Julia M. Burkhart, Sabine Creutzburg, Mekdes Debela, Manfred Schmitt, Christian Ries, and Viktor Magdolen
Biological Chemistry, 2010, Volume 391, Number 5
Karin Mengele, Rudolf Napieralski, Viktor Magdolen, Ute Reuning, Apostolos Gkazepis, Fred Sweep, Nils Brünner, John Foekens, Nadia Harbeck, and Manfred Schmitt
Expert Review of Molecular Diagnostics, 2010, Volume 10, Number 7, Page 947
Nicolai Sidenius and Francesco Blasi
AfCS-Nature Molecule Pages, 2009
Christoph Becker-Pauly, Markus Höwel, Tatjana Walker, Annica Vlad, Karin Aufenvenne, Vinzenz Oji, Daniel Lottaz, Erwin E Sterchi, Mekdes Debela, Viktor Magdolen, Heiko Traupe, and Walter Stöcker
Journal of Investigative Dermatology, 2007, Volume 127, Number 5, Page 1115

Comments (0)

Please log in or register to comment.