Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 387, Issue 6

Issues

Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more

Katerina Oikonomopoulou
  • Departments of Laboratory Medicine and Pathobiology, and of Pathology and Laboratory Medicine, University of Toronto and Mount Sinai Hospital, Toronto M5G 1X5, ON, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Kristina K. Hansen
  • Department of Pharmacology and Therapeutics, University of Calgary, Calgary T2N 4N1, AB, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mahmoud Saifeddine
  • Department of Pharmacology and Therapeutics, University of Calgary, Calgary T2N 4N1, AB, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Nathalie Vergnolle
  • Department of Pharmacology and Therapeutics, University of Calgary, Calgary T2N 4N1, AB, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Illa Tea
  • Department of Pharmacology and Therapeutics, University of Calgary, Calgary T2N 4N1, AB, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Eleftherios P. Diamandis
  • Departments of Laboratory Medicine and Pathobiology, and of Pathology and Laboratory Medicine, University of Toronto and Mount Sinai Hospital, Toronto M5G 1X5, ON, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Morley D. Hollenberg
  • Department of Pharmacology and Therapeutics, University of Calgary, Calgary T2N 4N1, AB, Canada and Department of Medicine, University of Calgary, Calgary T2N 4N1, AB, Canada
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2006-06-26 | DOI: https://doi.org/10.1515/BC.2006.086

Abstract

Serine proteinases, like trypsin, can play a hormone-like role by triggering signal transduction pathways in target cells. In many respects these hormone-like actions of proteinases can now be understood in terms of the pharmacodynamics of the G protein-coupled ‘receptor’ responsible for the cellular actions of thrombin (proteinase-activated receptor-1, or PAR1). PAR1, like the other three members of this receptor family (PAR2, PAR3 and PAR4), has a unique mechanism of activation involving the proteolytic unmasking of an N-terminally tethered sequence that can activate the receptor. The selective activation of each PAR by short synthetic peptides representing these sequences has demonstrated that PAR1, PAR2 and PAR4 play important roles in regulating physiological responses ranging from vasoregulation and cell growth to inflammation and nociception. We hypothesise that the tissue kallikreins may regulate signal transduction via the PARs. Although PARs can account for many of their biological actions, kallikreins may also cause effects by mechanisms not involving the PARs. For instance, trypsin activates the insulin receptor and thrombin can act via a mechanism involving its non-catalytic domains. Based on the data we summarise, we propose that the kallikreins, like thrombin and trypsin, must now be considered as important ‘hormonal’ regulators of tissue function.

Keywords: hormone action; inflammation; kallikreins; protease-activated receptors; proteases; proteinases; receptors; signal transduction; trypsin

About the article

Corresponding author


Published Online: 2006-06-26

Published in Print: 2006-06-01


Citation Information: Biological Chemistry, Volume 387, Issue 6, Pages 677–685, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.086.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Jacques Q. van der Merwe, Morley D. Hollenberg, and Wallace K. MacNaughton
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008, Volume 294, Number 2, Page G441
[2]
Jacques Q. van der Merwe, France Moreau, and Wallace K. MacNaughton
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2009, Volume 296, Number 6, Page G1258
[3]
Carlos López-Otín and Judith S. Bond
Journal of Biological Chemistry, 2008, Volume 283, Number 45, Page 30433
[4]
Yasuto Araki and Toshihide Mimura
International Journal of Molecular Sciences, 2017, Volume 18, Number 5, Page 905
[5]
Efrat Shavit-Stein, Avital Artan-Furman, Ekaterina Feingold, Marina Ben Shimon, Zeev Itzekson-Hayosh, Joab Chapman, Andreas Vlachos, and Nicola Maggio
Frontiers in Molecular Neuroscience, 2017, Volume 10
[6]
R. Ramachandran, C. Altier, K. Oikonomopoulou, and M. D. Hollenberg
Pharmacological Reviews, 2016, Volume 68, Number 4, Page 1110
[7]
Sreeja Sarojini, Ayala Tamir, Heejin Lim, Shihong Li, Shifang Zhang, Andre Goy, Andrew Pecora, and K. Stephen Suh
Journal of Oncology, 2012, Volume 2012, Page 1
[8]
H. L. Nichols, M. Saffeddine, B. S. Theriot, A. Hegde, D. Polley, T. El-Mays, H. Vliagoftis, M. D. Hollenberg, E. H. Wilson, J. K. L. Walker, and K. A. DeFea
Proceedings of the National Academy of Sciences, 2012, Volume 109, Number 41, Page 16660
[9]
Se-Hui Jung, Deok-Hoon Kong, Seoung-Woo Park, Young-Myeong Kim, and Kwon-Soo Ha
The Analyst, 2012, Volume 137, Number 16, Page 3814
[10]
Deok-Hoon Kong, Se-Hui Jung, Seung-Taek Lee, Young-Myeong Kim, and Kwon-Soo Ha
Biosensors and Bioelectronics, 2012, Volume 36, Number 1, Page 147
[11]
Hyunjae Chung, Magda Hamza, Katerina Oikonomopoulou, Valérie Gratio, Mahmoud Saifeddine, G. Duke Virca, Eleftherios P. Diamandis, Morley D. Hollenberg, and Dalila Darmoul
Biological Chemistry, 2012, Volume 393, Number 5
[12]
Jane Bayani and Eleftherios P. Diamandis
Clinical Chemistry and Laboratory Medicine (CCLM), 2012, Volume 50, Number 2
[13]
Nashmil Emami and Eleftherios P. Diamandis
Clinica Chimica Acta, 2007, Volume 381, Number 1, Page 78
[14]
Sachiyo Nishimura, Hiroyasu Ishikura, Maho Matsunami, Yui Shinozaki, Fumiko Sekiguchi, Mitsuhide Naruse, Taisuke Kitamura, Ryukichi Akashi, Kenji Matsumura, and Atsufumi Kawabata
Life Sciences, 2010, Volume 87, Number 19-22, Page 643
[15]
Julie Chao, Bo Shen, Lin Gao, Chun-Fang Xia, Grant Bledsoe, and Lee Chao
Biological Chemistry, 2010, Volume 391, Number 4
[16]
Katerina Oikonomopoulou, Ihor Batruch, Chris R. Smith, Antoninus Soosaipillai, Eleftherios P. Diamandis, and Morley D. Hollenberg
Biological Chemistry, 2010, Volume 391, Number 4
[18]
Valérie Gratio, Nathalie Beaufort, Lina Seiz, Josefine Maier, G. Duke Virca, Mekdes Debela, Nicolai Grebenchtchikov, Viktor Magdolen, and Dalila Darmoul
The American Journal of Pathology, 2010, Volume 176, Number 3, Page 1452
[19]
Lin Gao, Robert S. Smith, Li-Mei Chen, Karl X. Chai, Lee Chao, and Julie Chao
Biological Chemistry, 2010, Volume 391, Number 7
[20]
A Kawabata, M Matsunami, and F Sekiguchi
British Journal of Pharmacology, 2009, Volume 153, Number S1, Page S230
[21]
Peter Sommer, Viviana S. Fluxa, Tamis Darbre, and Jean-Louis Reymond
ChemBioChem, 2009, Volume 10, Number 9, Page 1527
[22]
H. Weiler and W. Ruf
Blood, 2007, Volume 110, Number 9, Page 3091
[23]
Wenbin Wang, Xiaotun Zhang, Gregory J. Mize, and Thomas K. Takayama
The Prostate, 2008, Volume 68, Number 10, Page 1064
[24]
Malin C. Lagerström and Helgi B. Schiöth
Nature Reviews Drug Discovery, 2008, Volume 7, Number 4, Page 339
[25]
Nahoko Komatsu, Kiyofumi Saijoh, Cynthia Kuk, Amber C. Liu, Saba Khan, Fumiaki Shirasaki, Kazuhiko Takehara, and Eleftherios P. Diamandis
Experimental Dermatology, 2007, Volume 16, Number 6, Page 513
[26]
N. Komatsu, K. Saijoh, C. Kuk, F. Shirasaki, K. Takehara, and E.P. Diamandis
British Journal of Dermatology, 2007, Volume 156, Number 5, Page 875

Comments (0)

Please log in or register to comment.
Log in