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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

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Volume 387, Issue 7 (Jul 2006)


Extracellular granzymes: current perspectives

Marguerite S. Buzza
  • Department of Biochemistry and Molecular Biology, Monash University, Melbourne 3800, Australia
/ Phillip I. Bird
  • Department of Biochemistry and Molecular Biology, Monash University, Melbourne 3800, Australia
Published Online: 2006-07-20 | DOI: https://doi.org/10.1515/BC.2006.106


Granzyme A (GrA) and granzyme B (GrB) play key roles in the induction of target cell death induced by cytotoxic lymphocytes. Whilst these roles have been extensively studied, it is becoming apparent that both granzymes also possess extracellular activities. Soluble granzymes are found extracellularly in normal plasma and are elevated in a number of diseases, ranging from viral and bacterial infections to autoimmune diseases. Here, we discuss the current knowledge of extracellular granzyme substrates, inhibitors and functions; and the pathological consequences of extracellular granzymes in disease. In addition, we provide new evidence for the role of glycosaminoglycan-binding sites of granzymes in extracellular matrix remodeling.

Keywords: extracellular matrix remodeling; perforin-independent; soluble granzyme A; soluble granzyme B


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Corresponding author

Published Online: 2006-07-20

Published in Print: 2006-07-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.106.

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