The aryl hydrocarbon receptor and light

Agneta Rannug; Ellen Fritsche

doi:10.1515/BC.2006.143

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The aryl hydrocarbon receptor and light

Agneta Rannug

Karolinska Institute, Institute of Environmental Medicine, P.O. Box 210, S-171 77 Stockholm, Sweden
Other articles by this author:
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/ Ellen Fritsche

Institut für Umweltmedizinische Forschung, Arbeitsgruppe Toxikologie, Auf'm Hennekamp 50, D-40225 Düsseldorf, Germany
Other articles by this author:
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Published Online: 2006-09-14 | DOI: https://doi.org/10.1515/BC.2006.143

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Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been intensively studied with respect to the toxicity of xenobiotics. However, its function in response to light has never been summarized. Here, we provide an overview of AhR activation by light with a focus on the role of tryptophan in light-induced AhR activation. We discuss the involvement of the AhR in different biological rhythms and speculate on the possible role of the AhR in UV-induced responses in skin. Furthermore, this review points out future research needs in this field.

Keywords: circadian rhythm; cytochrome P-4501A1 (CYP1A1); endogenous ligand; Per/ARNT/Sim (PAS); stress response; ultraviolet (UV) light

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Published Online: 2006-09-14

Published in Print: 2006-09-01

Citation Information: Biological Chemistry, Volume 387, Issue 9, Pages 1149–1157, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.143.

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