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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Online
ISSN
1437-4315
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Volume 387, Issue 9 (Sep 2006)

Issues

Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice

Markus Frericks
  • Institut für Umweltmedizinische Forschung (IUF) at the Heinrich-Heine University of Düsseldorf, Auf′m Hennekamp 50, D-40225 Düsseldorf, Germany
/ Vladimir V. Temchura
  • Institut für Umweltmedizinische Forschung (IUF) at the Heinrich-Heine University of Düsseldorf, Auf′m Hennekamp 50, D-40225 Düsseldorf, Germany and Present address: Department of Molecular and Medical Virology, University of Bochum, Universitätsstrasse 150, D-44801 Bochum, Germany
/ Marc Majora
  • Institut für Umweltmedizinische Forschung (IUF) at the Heinrich-Heine University of Düsseldorf, Auf′m Hennekamp 50, D-40225 Düsseldorf, Germany
/ Susanne Stutte
  • Institut für Umweltmedizinische Forschung (IUF) at the Heinrich-Heine University of Düsseldorf, Auf′m Hennekamp 50, D-40225 Düsseldorf, Germany
/ Charlotte Esser
  • Institut für Umweltmedizinische Forschung (IUF) at the Heinrich-Heine University of Düsseldorf, Auf′m Hennekamp 50, D-40225 Düsseldorf, Germany
Published Online: 2006-09-14 | DOI: https://doi.org/10.1515/BC.2006.151

Abstract

The ligand-activated aryl hydrocarbon receptor (AHR) is known to modulate many genes in a highly cell-specific manner, either directly or indirectly via secondary effects. In contrast, little is known about the effects of AHR deficiency on gene expression balance. We compared the transcriptome of CD4 T cells from AHR-/- mice and wild-type mice; 390 genes, many of them immunotypic, were deregulated in AHR-deficient CD4 cells. TCDD-induced transcriptome changes correlated with the AHR expression level in immune cells. However, there was little overlap in AHR-dependent transcripts found in T lineage cells or dendritic cells. Our results demonstrate flexible gene accessibility for the AHR in immune cells. The idea of a universal battery of AHR-responsive genes is not tenable.

Keywords: Affymetrix; aryl hydrocarbon receptor; CD4 T cells; dendritic cells; Lgals3; scinderin; thymocytes

References

About the article

Corresponding author


Received: May 26, 2006

Accepted: July 26, 2006

Published Online: 2006-09-14

Published in Print: 2006-09-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2006.151. Export Citation

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