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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Volume 388, Issue 10 (Oct 2007)


Effect of age on sexually dimorphic selenoprotein expression in mice

Lutz Schomburg
  • 1Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
/ Cornelia Riese
  • 2Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
/ Kostja Renko
  • 3Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
/ Ulrich Schweizer
  • 4Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
Published Online: 2007-10-16 | DOI: https://doi.org/10.1515/BC.2007.128


Clinical data suggest that selenium (Se) supplementation decreases disease predisposition and severity and accelerates recovery in a variety of pathologies. Pre-supplementation Se levels and sex represent important determinants of these Se-dependent health effects. Accordingly, we previously reported on sexually dimorphic expression patterns of Se-dependent glutathione peroxidase 1, type I deiodinase, and selenoprotein P in young mice. In the present study we investigated whether these differences vary with age. The strong sexual dimorphic expression of hepatic type I deiodinase that was observed in young mice vanished both at the mRNA and enzyme activity level by 1 year of age. In contrast, the strong sex-specific differences in renal type I deiodinase mRNA expression were sustained with age. Accordingly, deiodinase enzymatic activities differed in male and female kidneys, largely independent of age [average of 6.8 vs. 15.7 pmol/(min mg) in males vs. females]. In parallel, hepatic Se concentrations and glutathione peroxidase activities increased in female mice compared to male littermates, establishing a new sexual dimorphism in liver. Thus, age represents another important modifier of the dynamic sex- and tissue-specific selenoprotein expression patterns. These data highlight again the unique physiological regulatory mechanisms that have evolved to control Se metabolism according to the actual needs of the organism.

Keywords: deiodinase; gender; stability; trace element; translational efficiency

About the article

Corresponding author

Received: 2007-05-30

Accepted: 2007-06-26

Published Online: 2007-10-16

Published in Print: 2007-10-01

Citation Information: Biological Chemistry, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2007.128. Export Citation

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