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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

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Online
ISSN
1437-4315
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Volume 388, Issue 10 (Oct 2007)

Issues

Effect of age on sexually dimorphic selenoprotein expression in mice

Lutz Schomburg
  • 1Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
/ Cornelia Riese
  • 2Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
/ Kostja Renko
  • 3Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
/ Ulrich Schweizer
  • 4Institute for Experimental Endocrinology, Charité-University Medicine Berlin, D-10117 Berlin, Germany
Published Online: 2007-10-16 | DOI: https://doi.org/10.1515/BC.2007.128

Abstract

Clinical data suggest that selenium (Se) supplementation decreases disease predisposition and severity and accelerates recovery in a variety of pathologies. Pre-supplementation Se levels and sex represent important determinants of these Se-dependent health effects. Accordingly, we previously reported on sexually dimorphic expression patterns of Se-dependent glutathione peroxidase 1, type I deiodinase, and selenoprotein P in young mice. In the present study we investigated whether these differences vary with age. The strong sexual dimorphic expression of hepatic type I deiodinase that was observed in young mice vanished both at the mRNA and enzyme activity level by 1 year of age. In contrast, the strong sex-specific differences in renal type I deiodinase mRNA expression were sustained with age. Accordingly, deiodinase enzymatic activities differed in male and female kidneys, largely independent of age [average of 6.8 vs. 15.7 pmol/(min mg) in males vs. females]. In parallel, hepatic Se concentrations and glutathione peroxidase activities increased in female mice compared to male littermates, establishing a new sexual dimorphism in liver. Thus, age represents another important modifier of the dynamic sex- and tissue-specific selenoprotein expression patterns. These data highlight again the unique physiological regulatory mechanisms that have evolved to control Se metabolism according to the actual needs of the organism.

Keywords: deiodinase; gender; stability; trace element; translational efficiency

About the article

Corresponding author


Received: 2007-05-30

Accepted: 2007-06-26

Published Online: 2007-10-16

Published in Print: 2007-10-01


Citation Information: Biological Chemistry, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2007.128. Export Citation

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[1]
Gerasimos E Krassas, Nikolaos Pontikides, Kostas Tziomalos, Themistoklis Tzotzas, Ioana Zosin, Mihaela Vlad, Anton Luger, Alois Gessl, Rodrig Marculescu, Vincenzo Toscano, Sara Morgante, Enrico Papini, Valdis Pirags, Ilze Konrade, Sandra Hybsier, Peter J Hofmann, Lutz Schomburg, and Josef Köhrle
Expert Review of Endocrinology & Metabolism, 2014, Volume 9, Number 6, Page 685
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Andrea S.T. Dewing, Rachel H. Rueli, Michael J. Robles, Elizabeth D. Nguyen-Wu, Thomas Zeyda, Marla J. Berry, and Frederick P. Bellinger
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B. Sosic-Jurjevic, B. Filipovic, K. Renko, V. Ajdzanovic, M. Manojlovic-Stojanoski, V. Milosevic, and J. Kohrle
Journal of Endocrinology, 2012, Volume 215, Number 2, Page 247
[4]
Gerald F. Combs, Matthew I. Jackson, Jennifer C. Watts, LuAnn K. Johnson, Huawei Zeng, Joseph Idso, Lutz Schomburg, Antonia Hoeg, Carolin S. Hoefig, Emily C. Chiang, David J. Waters, Cindy D. Davis, and John A. Milner
British Journal of Nutrition, 2012, Volume 107, Number 10, Page 1514
[5]
Maxime Y. Tondreau, Eric Boucher, Marc Simard, Yves Tremblay, and Jean-François Bilodeau
Molecular and Cellular Endocrinology, 2012, Volume 355, Number 1, Page 87
[6]
Zhi Huang, Aaron H. Rose, and Peter R. Hoffmann
Antioxidants & Redox Signaling, 2012, Volume 16, Number 7, Page 705
[7]
Lone Banke Rasmussen, Birgit Hollenbach, Peter Laurberg, Allan Carlé, Antonia Hög, Torben Jørgensen, Pernille Vejbjerg, Lars Ovesen, and Lutz Schomburg
Journal of Trace Elements in Medicine and Biology, 2009, Volume 23, Number 4, Page 265
[8]
Lutz Schomburg and Ulrich Schweizer
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009, Volume 1790, Number 11, Page 1453

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