Jump to ContentJump to Main Navigation
Show Summary Details

Buchner, Johannes

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing



Select Volume and Issue


Cysteine cathepsin non-inhibitory binding partners: modulating intracellular trafficking and function

Bernadette C. Victor1 / Bonnie F. Sloane2

1Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA

2Department of Pharmacology and Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA

Corresponding author

Citation Information: Biological Chemistry. Volume 388, Issue 11, Pages 1131–1140, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2007.150, November 2007

Publication History

Published Online:


Cysteine cathepsins play a fundamental role in tumor growth, invasion and migration, angiogenesis, and the metastatic cascade. Evidence of their overexpression in a wide array of human tumors has been well documented. Cysteine cathepsins seem to have a characteristic location-function relationship that leads to non-traditional roles such as those in development and pathology. For example, during tumor development, some cysteine cathepsins are found not just within lysosomes, but are also redistributed into presumptive exocytic vesicles at the cell periphery, resulting in their secretion. This altered localization contributes to non-lysosomal functions that have been linked to malignant progression. Mechanisms for altered localization are not well understood, but do include the interaction of cysteine cathepsins with binding partners that modulate intracellular trafficking and association with specific regions on the cell surface.

Keywords: cancer; cathepsin B; cysteine cathepsin; glycosaminoglycan

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Janko Kos, Zala Jevnikar, and Nataša Obermajer
Cell Adhesion & Migration, 2009, Volume 3, Number 2, Page 164
D.M. Brix, B. Rafn, K. Bundgaard Clemmensen, S.H. Andersen, N. Ambartsumian, M. Jäättelä, and T. Kallunki
Molecular Oncology, 2014, Volume 8, Number 8, Page 1703
F Bengsch, A Buck, S C Günther, J R Seiz, M Tacke, D Pfeifer, D von Elverfeldt, L Sevenich, L E Hillebrand, U Kern, M Sameni, C Peters, B F Sloane, and T Reinheckel
Oncogene, 2014, Volume 33, Number 36, Page 4474
T Kallunki, O D Olsen, and M Jäättelä
Oncogene, 2013, Volume 32, Number 16, Page 1995
Marko Novinec, Brigita Lenarčič, and Antonio Baici
FEBS Letters, 2012, Volume 586, Number 7, Page 1062
Jennifer M. Rothberg, Mansoureh Sameni, Kamiar Moin, and Bonnie F. Sloane
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012, Volume 1824, Number 1, Page 123
Tino Kurz, Alexei Terman, Bertil Gustafsson, and Ulf T. Brunk
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008, Volume 1780, Number 11, Page 1291
Alexei Terman, Tino Kurz, Marian Navratil, Edgar A. Arriaga, and Ulf T. Brunk
Antioxidants & Redox Signaling, 2010, Volume 12, Number 4, Page 503
Anke Klose, Astrid Wilbrand-Hennes, Jürgen Brinckmann, and Nicolas Hunzelmann
Experimental Dermatology, 2009, Volume 19, Number 8, Page e117
Stephan Hailfinger, Fabien Rebeaud, and Margot Thome
Immunological Reviews, 2009, Volume 232, Number 1, Page 334
Tino Kurz, Alexei Terman, Bertil Gustafsson, and Ulf T. Brunk
Histochemistry and Cell Biology, 2008, Volume 129, Number 4, Page 389

Comments (0)

Please log in or register to comment.