Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

See all formats and pricing
More options …
Volume 388, Issue 11


Two decades of thyroglobulin type-1 domain research

Marko Mihelič
  • 1Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dušan Turk
  • 2Department of Biochemistry, Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-11-02 | DOI: https://doi.org/10.1515/BC.2007.155


Thyroglobulin type-1 repeats are primarily found in thyroglobulin and several other functionally unrelated proteins. Because a few of them exhibit inhibitory activity against cysteine proteases they were named thyropins (thyroglobulin type-1 domain protease inhibitors). In contrast to cystatins, the best-characterized group of papain-like protease inhibitors, they exhibit greater selectivity in their interactions with target proteases. Interestingly, a few members inhibit aspartic protease cathepsin D and metalloproteases. In contrast to the inhibitory fragment of the major histocompatibility complex class II-associated p41 form of invariant chain, whose structural integrity appears mandatory for its inhibitory properties, short polypeptides derived from insulin-like growth factor-binding proteins exhibit the same activity as the structure of the whole fragment. Taken together, the results indicate that the thyroglobulin type-1 repeat is a structural motif occasionally employed as an inhibitor of proteases.

Keywords: cysteine protease; equistatin; IGFBP; invariant chain; p41 fragment; thyropin

About the article

Corresponding author

Published Online: 2007-11-02

Published in Print: 2007-11-01

Citation Information: Biological Chemistry, Volume 388, Issue 11, Pages 1123–1130, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2007.155.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Jaemin Lee, Bruno Di Jeso, and Peter Arvan
Journal of Biological Chemistry, 2011, Volume 286, Number 38, Page 33045
Miha Renko, Jerica Sabotič, Marko Mihelič, Jože Brzin, Janko Kos, and Dušan Turk
Journal of Biological Chemistry, 2010, Volume 285, Number 1, Page 308
Jaemin Lee and Peter Arvan
Journal of Biological Chemistry, 2011, Volume 286, Number 30, Page 26327
Marko Mihelič, Andreja Doberšek, Gregor Gunčar, and Dušan Turk
Journal of Biological Chemistry, 2008, Volume 283, Number 21, Page 14453
Lucas Tirloni, José Reck, Renata Maria Soares Terra, João Ricardo Martins, Albert Mulenga, Nicholas E. Sherman, Jay W. Fox, John R. Yates, Carlos Termignoni, Antônio F. M. Pinto, Itabajara da Silva Vaz, and Claudio R. Lazzari
PLoS ONE, 2014, Volume 9, Number 4, Page e94831
Tina Zavašnik-Bergant, Martina Bergant Marušič, and Fabrizio Mattei
PLOS ONE, 2016, Volume 11, Number 3, Page e0150815
Chen Huang, Jean-Étienne RL Morlighem, Hefeng Zhou, Érica P Lima, Paula B Gomes, Jing Cai, Inchio Lou, Carlos D Pérez, Simon Ming Lee, and Gandhi Rádis-Baptista
Genome Biology and Evolution, 2016, Volume 8, Number 9, Page 3045
Mateusz Kędzior, Rafał Seredyński, and Jan Gutowicz
Medical Microbiology and Immunology, 2016, Volume 205, Number 4, Page 275
Dong Seon Kim and Yoonsoo Hahn
BMC Bioinformatics, 2015, Volume 16, Number 1
Annie R.A. McDougall, Mary Tolcos, Stuart B. Hooper, Timothy J. Cole, and Megan J. Wallace
Developmental Dynamics, 2015, Volume 244, Number 2, Page 99
Ulrike Schnell, Jeroen Kuipers, and Ben N. G. Giepmans
Bioscience Reports, 2013, Volume 33, Number 2
Fangfang Chen, Chao Wu, Ling Pan, Fazhi Xu, Xuelan Liu, and Weiyi Yu
Developmental & Comparative Immunology, 2013, Volume 40, Number 1, Page 20
Amy D. Bradshaw
The International Journal of Biochemistry & Cell Biology, 2012, Volume 44, Number 3, Page 480
Dejan Suban, Tajana Zajc, Miha Renko, Boris Turk, Vito Turk, and Iztok Dolenc
Biochimie, 2012, Volume 94, Number 3, Page 719
Vito Turk, Veronika Stoka, Olga Vasiljeva, Miha Renko, Tao Sun, Boris Turk, and Dušan Turk
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012, Volume 1824, Number 1, Page 68
Michael F. Criscitiello, Yuko Ohta, Matthew D. Graham, Jeannine O. Eubanks, Patricia L. Chen, and Martin F. Flajnik
Developmental & Comparative Immunology, 2012, Volume 36, Number 3, Page 521
Qi Zheng, Yiwen Wang, Eric Vargas, and Stephen DiNardo
Developmental Biology, 2011, Volume 357, Number 1, Page 202
Tomasz Kantyka, Neil D. Rawlings, and Jan Potempa
Biochimie, 2010, Volume 92, Number 11, Page 1644

Comments (0)

Please log in or register to comment.
Log in