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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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1437-4315
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Volume 388, Issue 7 (Jul 2007)

Issues

Idiosyncratic cleavage and ligation activity of individual hammerhead ribozymes and core sequence variants thereof

Rita Przybilski
  • 1AG Molecular Interactions, Department of Genetics, University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Christian Hammann
  • 2AG Molecular Interactions, Department of Genetics, University of Kassel, Heinrich-Plett-Str. 40, D-34132 Kassel, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-07-01 | DOI: https://doi.org/10.1515/BC.2007.065

Abstract

The hammerhead ribozyme is a small RNA endonuclease found in sub-viral plant pathogens, in transcripts from certain animal satellite DNAs and encoded at distinct loci of Arabidopsis thaliana. Kinetic analyses of tertiary stabilised ribozymes from peach latent mosaic viroid (PLMVd), Schistosoma mansoni and A. thaliana revealed a ten-fold difference in cleavage rates. Core nucleotide variations affected cleavage reactions least in the A. thaliana ribozyme, and most in the S. mansoni ribozyme. The reverse ligation reaction was catalysed efficiently by the PLMVd and A. thaliana ribozymes. The different behaviour of the individual hammerhead ribozymes is discussed in terms of structure and function.

Keywords: catalytic RNA; divalent metal ions; RNA structure; satellite DNA; viroid

About the article

Corresponding author


Received: 2007-02-13

Accepted: 2007-03-02

Published Online: 2007-07-01


Citation Information: Biological Chemistry, ISSN (Online) 14316730, ISSN (Print) 14374315, DOI: https://doi.org/10.1515/BC.2007.065.

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