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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

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ISSN
1437-4315
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Volume 388, Issue 7

Issues

RNA self-processing towards changed topology and sequence oligomerization

Stefan Pieper
  • 1Ernst-Moritz-Arndt-Universiät Greifswald, Institut für Biochemie, Abt. Bioorganische Chemie, Felix-Hausdorff-Str. 4, D-17487 Greifswald, Germany
    Present address: Humboldt-Universität Berlin, Institut für Chemie, Brook-Taylor-Str. 2, D-12489 Berlin, Germany.
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Stéphanie Vauléon
  • 2Ernst-Moritz-Arndt-Universiät Greifswald, Institut für Biochemie, Abt. Bioorganische Chemie, Felix-Hausdorff-Str. 4, D-17487 Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Sabine Müller
  • 3Ernst-Moritz-Arndt-Universiät Greifswald, Institut für Biochemie, Abt. Bioorganische Chemie, Felix-Hausdorff-Str. 4, D-17487 Greifswald, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-07-01 | DOI: https://doi.org/10.1515/BC.2007.067

Abstract

Reversible chemistry, allowing for chain-forming as well as chain-breaking steps, is important for biological self-organization. In this context, ribozymes, catalyzing both RNA cleavage and ligation, may have significantly contributed to extending the sequence space and length of RNA molecules in early life forms. Here we present an engineered RNA that self-processes by passing through a number of cleavage and ligation steps. Intermolecular reactions compete with intramolecular reactions, resulting in a variety of products. Our results demonstrate that RNA can undergo self-oligomerization, which may have been important for extending the RNA genome size in RNA world scenarios.

Keywords: catalysis; cleavage; cyclic RNA; ligation; ribozyme; RNA world

About the article

Corresponding author


Received: 2007-02-09

Accepted: 2007-03-05

Published Online: 2007-07-01


Citation Information: Biological Chemistry, Volume 388, Issue 7, Pages 743–746, ISSN (Online) 14316730, ISSN (Print) 14374315, DOI: https://doi.org/10.1515/BC.2007.067.

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