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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 388, Issue 8

Issues

PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis

François Lépine / Valérie Dekimpe / Biliana Lesic
  • 3Department of Surgery, Harvard Medical School, Massachusetts General Hospital, and Shriner's Burns Institute, Boston, MA 02114, USA
  • Other articles by this author:
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/ Sylvain Milot / Alain Lesimple
  • 5McGill Biomedical Mass Spectrometry Unit, McGill University, Montreal H3A 1A4, Quebec, Canada
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/ Orval A. Mamer
  • 6McGill Biomedical Mass Spectrometry Unit, McGill University, Montreal H3A 1A4, Quebec, Canada
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/ Laurence G. Rahme
  • 7Department of Surgery, Harvard Medical School, Massachusetts General Hospital, and Shriner's Burns Institute, Boston, MA 02114, USA
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/ Eric Déziel
Published Online: 2007-08-01 | DOI: https://doi.org/10.1515/BC.2007.100

Abstract

A new metabolite, 2,4-dihydroxyquinoline (DHQ), was identified in cultures of the bacteria Pseudomonas aeruginosa and Burkholderia thailandensis. We found that the biosynthesis of DHQ correlates with the presence of a functional PqsA, which is a product of the pqsABCDE operon responsible for the synthesis of 4-hydroxy-2-alkylquinolines (HAQs) in P. aeruginosa. However, DHQ is not a degradation product or precursor of HAQs. This finding sheds some light on the poorly understood biosynthesis pathway of HAQs, which includes important communication signals regulating the expression of virulence factors.

Keywords: 2,4-dihydroxyquinoline; 4-hydroxy-2-alkylquinolines; mass spectrometry; natural product; Pseudomonas aeruginosa; PqsA

About the article

Corresponding author


Received: 2007-04-19

Accepted: 2007-05-11

Published Online: 2007-08-01


Citation Information: Biological Chemistry, Volume 388, Issue 8, Pages 839–845, ISSN (Online) 14316730, ISSN (Print) 14374315, DOI: https://doi.org/10.1515/BC.2007.100.

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