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Licensed Unlicensed Requires Authentication Published by De Gruyter August 14, 2007

Diverse mechanisms and machineries for import of mitochondrial proteins

  • Dusanka Milenkovic , Judith Müller , Diana Stojanovski , Nikolaus Pfanner and Agnieszka Chacinska
From the journal Biological Chemistry

Abstract

Mitochondria are ubiquitous organelles that play an essential role in energy conversion and biosynthetic pathways in eukaryotic cells. Most mitochondrial proteins must be imported from the cytosol and sorted into one of the four mitochondrial subcompartments, the outer membrane, the intermembrane space, the inner membrane and the matrix. Studies in recent years revealed a remarkable diversity of mechanisms and machineries that are required for the import of proteins into mitochondria. At least four different pathways for the sorting and assembly of nuclear-encoded mitochondrial proteins have been identified.


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Published Online: 2007-08-14
Published in Print: 2007-09-01

©2007 by Walter de Gruyter Berlin New York

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