Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 389, Issue 1

Issues

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx

Daniel Chappell
  • 1Clinic of Anaesthesiology, Ludwig Maximilians University, Nussbaumstr. 20, D-80336 Munich, Germany and Institute of Physiology, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Matthias Jacob
  • 2Clinic of Anaesthesiology, Ludwig Maximilians University, Nussbaumstr. 20, D-80336 Munich, Germany and Institute of Physiology, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Markus Rehm
  • 3Clinic of Anaesthesiology, Ludwig Maximilians University, Nussbaumstr. 20, D-80336 Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mechthild Stoeckelhuber
  • 4Institute of Anatomy, Ludwig Maximilians University, Pettenkoferstr. 11, D-80336 Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Ulrich Welsch
  • 5Institute of Anatomy, Ludwig Maximilians University, Pettenkoferstr. 11, D-80336 Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Peter Conzen
  • 6Clinic of Anaesthesiology, Ludwig Maximilians University, Nussbaumstr. 20, D-80336 Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bernhard F. Becker
  • 7Institute of Physiology, Ludwig Maximilians University, Schillerstr. 44, D-80336 Munich, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2007-12-20 | DOI: https://doi.org/10.1515/BC.2008.005

Abstract

A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates. This structure maintains the physiological endothelial permeability barrier and prevents leukocyte and platelet adhesion, thereby mitigating inflammation and tissue oedema. Heparinase, a bacterial analogue to heparanase, is known to attack the glycocalyx. However, the exact extent and specificity of degradation is unresolved. We show by electron microscopy, immunohistological staining and quantitative measurements of the constituent parts, that heparinase selectively sheds heparan sulphate from the glycocalyx, but not the syndecans.

Keywords: coronary system; endothelium; heart; permeability barrier; syndecans

About the article

Corresponding author


Received: 2007-07-09

Accepted: 2007-09-20

Published Online: 2007-12-20

Published in Print: 2008-01-01


Citation Information: Biological Chemistry, Volume 389, Issue 1, Pages 79–82, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2008.005.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Hong-Ru Chen, Yen-Chung Lai, and Trai-Ming Yeh
Journal of Biomedical Science, 2018, Volume 25, Number 1
[2]
Hong-Ru Chen, Chiao-Hsuan Chao, Ching-Chuan Liu, Tzong-Shiann Ho, Huey-Pin Tsai, Guey-Chuen Perng, Yee-Shin Lin, Jen-Ren Wang, Trai-Ming Yeh, and Ana Fernandez-Sesma
PLOS Pathogens, 2018, Volume 14, Number 4, Page e1007033
[3]
Jong Wook Song and Michael S. Goligorsky
Korean Journal of Anesthesiology, 2018, Volume 71, Number 2, Page 92
[4]
Paul N. Hopkins
Physiological Reviews, 2013, Volume 93, Number 3, Page 1317
[5]
Vladimir Cerny, David Astapenko, Florian Brettner, Jan Benes, Radomir Hyspler, Christian Lehmann, and Zdenek Zadak
Critical Reviews in Clinical Laboratory Sciences, 2017, Page 1
[6]
Jane Fisher, James A. Russell, Peter Bentzer, Devyn Parsons, Stefano Secchia, Matthias Mörgelin, Keith R. Walley, John H. Boyd, and Adam Linder
SHOCK, 2017, Volume 48, Number 3, Page 313
[7]
Yimu Yang, Sarah M. Haeger, Matthew A. Suflita, Fuming Zhang, Kyrie L. Dailey, James F. Colbert, Joshay A. Ford, Mario A. Picon, Robert S. Stearman, Lei Lin, Xinyue Liu, Xiaorui Han, Robert J. Linhardt, and Eric P. Schmidt
American Journal of Respiratory Cell and Molecular Biology, 2017, Volume 56, Number 6, Page 727
[8]
Herbert H. Lipowsky and Anne Lescanic
Microvascular Research, 2017, Volume 112, Page 72
[9]
Bernd Uhl, Stephanie Hirn, Roland Immler, Karina Mildner, Leonhard Möckl, Markus Sperandio, Christoph Bräuchle, Christoph A. Reichel, Dagmar Zeuschner, and Fritz Krombach
ACS Nano, 2017, Volume 11, Number 2, Page 1498
[10]
Leonhard Möckl, Stephanie Hirn, Adriano A Torrano, Bernd Uhl, Christoph Bräuchle, and Fritz Krombach
Nanomedicine, 2017, Volume 12, Number 3, Page 207
[11]
Wanyi Yen, Bin Cai, Jinlin Yang, Lin Zhang, Min Zeng, John M. Tarbell, Bingmei M. Fu, and John Calvert
PLOS ONE, 2015, Volume 10, Number 1, Page e0117133
[12]
Peter Bentzer, Jane Fisher, HyeJin Julia Kong, Mattias Mörgelin, John H. Boyd, Keith R. Walley, James A. Russell, and Adam Linder
Intensive Care Medicine Experimental, 2016, Volume 4, Number 1
[13]
Lipeng Wang, Xiao Huang, Guiqing Kong, Haixiao Xu, Jiankui Li, Dong Hao, Tao Wang, Shasha Han, Chunlei Han, Yeying Sun, Xiangyong Liu, and Xiaozhi Wang
Biochemical and Biophysical Research Communications, 2016, Volume 478, Number 2, Page 669
[14]
Guiqing Kong, Xiao Huang, Lipeng Wang, Yan Li, Ting Sun, Shasha Han, Weiwei Zhu, Mingming Ma, Haixiao Xu, Jiankui Li, Xiaohua Zhang, Xiangyong Liu, and Xiaozhi Wang
International Immunopharmacology, 2016, Volume 36, Page 51
[15]
Aravinthan Varatharaj and Ian Galea
Brain, Behavior, and Immunity, 2017, Volume 60, Page 1
[16]
Michael Schnoor, Pilar Alcaide, Mathieu-Benoit Voisin, and Jaap D. van Buul
Mediators of Inflammation, 2015, Volume 2015, Page 1
[17]
Bernhard F. Becker, Matthias Jacob, Stephanie Leipert, Andrew H. J. Salmon, and Daniel Chappell
British Journal of Clinical Pharmacology, 2015, Volume 80, Number 3, Page 389
[18]
R. Brian Stevens, Kirk W. Foster, Clifford D. Miles, James T. Lane, Andre C. Kalil, Diana F. Florescu, John P. Sandoz, Theodore H. Rigley, Kathleen J. Nielsen, Jill Y. Skorupa, Anna M. Kellogg, Tamer Malik, and Lucile E. Wrenshall
Transplantation, 2015, Volume 99, Number 1, Page 197
[19]
D. Duerschmied, C. Bode, and I. Ahrens
Thrombosis and Haemostasis, 2014, Volume 112, Number 4, Page 678
[21]
Hana Kolářová, Barbora Ambrůzová, Lenka Švihálková Šindlerová, Anna Klinke, and Lukáš Kubala
Mediators of Inflammation, 2014, Volume 2014, Page 1
[22]
Kristina M. Giantsos-Adams, Andrew Jia-An Koo, Sukhyun Song, Jiro Sakai, Jagadish Sankaran, Jennifer H. Shin, Guillermo Garcia-Cardena, and C. Forbes Dewey
Cellular and Molecular Bioengineering, 2013, Volume 6, Number 2, Page 160
[23]
Mike Sebastian Strunden, Anika Bornscheuer, Anke Schuster, Rainer Kiefmann, Alwin E. Goetz, and Kai Heckel
Shock, 2012, Volume 38, Number 5, Page 559
[24]
Eric P Schmidt, Yimu Yang, William J Janssen, Aneta Gandjeva, Mario J Perez, Lea Barthel, Rachel L Zemans, Joel C Bowman, Dan E Koyanagi, Zulma X Yunt, Lynelle P Smith, Sara S Cheng, Katherine H Overdier, Kathy R Thompson, Mark W Geraci, Ivor S Douglas, David B Pearse, and Rubin M Tuder
Nature Medicine, 2012, Volume 18, Number 8, Page 1217
[25]
Stefanie Korte, Anne Wiesinger, Alexandra S. Straeter, Wladimir Peters, Hans Oberleithner, and Kristina Kusche-Vihrog
Pflügers Archiv - European Journal of Physiology, 2012, Volume 463, Number 2, Page 269
[26]
María José Soler, Marta Riera, Álex Gutierrez, and Julio Pascual
Transplantation Reviews, 2012, Volume 26, Number 1, Page 44
[27]
T. Annecke, J. Fischer, H. Hartmann, J. Tschoep, M. Rehm, P. Conzen, C. P. Sommerhoff, and B. F. Becker
BJA: British Journal of Anaesthesia, 2011, Volume 107, Number 5, Page 679
[28]
L. N. Broekhuizen, B. A. Lemkes, H. L. Mooij, M. C. Meuwese, H. Verberne, F. Holleman, R. O. Schlingemann, M. Nieuwdorp, E. S. G. Stroes, and H. Vink
Diabetologia, 2010, Volume 53, Number 12, Page 2646
[29]
MICHAELA PAPTISTELLA, DANIEL CHAPPELL, KLAUS HOFMANN-KIEFER, TOBIAS KAMMERER, PETER CONZEN, and MARKUS REHM
Transfusion Alternatives in Transfusion Medicine, 2010, Volume 11, Number 3, Page 92
[30]
Bernhard F. Becker, Daniel Chappell, and Matthias Jacob
Basic Research in Cardiology, 2010, Volume 105, Number 6, Page 687
[31]
Helen M. McGettrick, Christopher D. Buckley, Andrew Filer, G. Ed Rainger, and Gerard B. Nash
Immunology, 2010, Volume 131, Number 3, Page 357
[32]
Matthias Jacob, Oliver Paul, Laurenz Mehringer, Daniel Chappell, Markus Rehm, Ulrich Welsch, Ingo Kaczmarek, Peter Conzen, and Bernhard F. Becker
Transplantation, 2009, Volume 87, Number 7, Page 956
[33]
B. F. Becker, D. Chappell, D. Bruegger, T. Annecke, and M. Jacob
Cardiovascular Research, 2010, Volume 87, Number 2, Page 300
[34]
D. Chappell, M. Jacob, K. Hofmann-Kiefer, M. Rehm, U. Welsch, P. Conzen, and B. F. Becker
Cardiovascular Research, 2009, Volume 83, Number 2, Page 388
[35]
Daniel Chappell, Martin Westphal, and Matthias Jacob
Current Opinion in Anaesthesiology, 2009, Volume 22, Number 2, Page 155
[36]
Daniel Chappell, Klaus Hofmann-Kiefer, Matthias Jacob, Markus Rehm, Josef Briegel, Ulrich Welsch, Peter Conzen, and Bernhard F. Becker
Basic Research in Cardiology, 2009, Volume 104, Number 1, Page 78
[37]
D. Chappell, M. Jacob, B.F. Becker, K. Hofmann-Kiefer, P. Conzen, and M. Rehm
Der Anaesthesist, 2008, Volume 57, Number 10, Page 959

Comments (0)

Please log in or register to comment.
Log in