Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

See all formats and pricing
More options …
Volume 389, Issue 10


RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade

Stephan Pleschka
  • 1Institute for Medical Virology, Justus Liebig University, Frankfurter Str. 107, D-35392 Giessen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-08-19 | DOI: https://doi.org/10.1515/BC.2008.145


The Raf/MEK/ERK signal transduction cascade belongs to the mitogen-activated protein kinase (MAPK) cascades. Raf/MEK/ERK signaling leads to stimulus-specific changes in gene expression, alterations in cell metabolism or induction of programmed cell death (apoptosis), and thus controls cell differentiation and proliferation. It is induced by extracellular agents, including pathogens such as RNA viruses. Many DNA viruses are known to induce cellular signaling via this pathway. As these pathogens partly use the DNA synthesis machinery for their replication, they aim to drive cells into a proliferative state. In contrast, the consequences of RNA virus-induced Raf/MEK/ERK signaling were less clear for a long time, but since the turn of the century the number of publications on this topic has rapidly increased. Research on this virus/host-interaction will broaden our understanding of its relevance in viral replication. This important control center of cellular responses is differently employed to support the replication of several important human pathogenic RNA viruses including influenza, Ebola, hepatitis C and SARS corona viruses.

Keywords: extracellular signal-regulated kinase; virus replication

About the article

Received: 2008-03-21

Accepted: 2008-06-06

Published Online: 2008-08-19

Published in Print: 2008-10-01

Citation Information: Biological Chemistry, Volume 389, Issue 10, Pages 1273–1282, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.145.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Peng Xu, Aaron Yun Chen, Safder S. Ganaie, Fang Cheng, Weiran Shen, Xiaomei Wang, Steve Kleiboeker, Yi Li, Jianming Qiu, and Jae U. Jung
Journal of Virology, 2018, Volume 93, Number 1
Mahmoud Soliman, Deok-Song Kim, Jun-Gyu Park, Ji-Yun Kim, Mia Madel Alfajaro, Yeong-Bin Baek, Eun-Hyo Cho, Chul-Ho Park, Mun-Il Kang, Sang-Ik Park, Kyoung-Oh Cho, and Susana López
Journal of Virology, 2018, Volume 92, Number 24
Chelsea Pinkham, Aslaa Ahmed, Nicole Bracci, Aarthi Narayanan, and Kylene Kehn-Hall
Antiviral Research, 2018
Sara Landeras-Bueno, Yolanda Fernández, Ana Falcón, Juan Carlos Oliveros, and Juan Ortín
mBio, 2016, Volume 7, Number 2
U. Chuluunbaatar, R. Roller, and I. Mohr
Journal of Virology, 2012, Volume 86, Number 15, Page 7771
J. Yue, R. Shukla, R. Accardi, I. Zanella-Cleon, M. Siouda, M.-P. Cros, V. Krutovskikh, I. Hussain, Y. Niu, S. Hu, M. Becchi, P. Jurdic, M. Tommasino, and B. S. Sylla
Journal of Virology, 2011, Volume 85, Number 17, Page 8477
Jason Kindrachuk, Britini Ork, Brit J. Hart, Steven Mazur, Michael R. Holbrook, Matthew B. Frieman, Dawn Traynor, Reed F. Johnson, Julie Dyall, Jens H. Kuhn, Gene G. Olinger, Lisa E. Hensley, and Peter B. Jahrling
Antimicrobial Agents and Chemotherapy, 2015, Volume 59, Number 2, Page 1088
K. B. O'Brien, S. Schultz-Cherry, and L. J. Knoll
Journal of Virology, 2011, Volume 85, Number 17, Page 8680
T. R. Johnson, J. S. McLellan, and B. S. Graham
Journal of Virology, 2012, Volume 86, Number 3, Page 1339
S. Marozin, J. Altomonte, S. Apfel, P. X. Dinh, E. N. De Toni, A. Rizzani, A. Nussler, N. Kato, R. M. Schmid, A. K. Pattnaik, and O. Ebert
Journal of Virology, 2012, Volume 86, Number 9, Page 4844
J. L. Smith, D. A. Stein, D. Shum, M. A. Fischer, C. Radu, B. Bhinder, H. Djaballah, J. A. Nelson, K. Fruh, and A. J. Hirsch
Journal of Virology, 2014, Volume 88, Number 10, Page 5533
Jesús Brunetti, Sabrina Foscaldi, Verónica Quintana, Luis Scolaro, Nora López, and Viviana Castilla
Viruses, 2018, Volume 10, Number 4, Page 199
Julianna Han, Jasmine T. Perez, Cindy Chen, Yan Li, Asiel Benitez, Matheswaran Kandasamy, Yoontae Lee, Jorge Andrade, Benjamin tenOever, and Balaji Manicassamy
Cell Reports, 2018, Volume 23, Number 2, Page 596
Weiwei Liu, Xusheng Qiu, Cuiping Song, Yingjie Sun, Chunchun Meng, Ying Liao, Lei Tan, Zhuang Ding, Xiufan Liu, and Chan Ding
Viruses, 2018, Volume 10, Number 4, Page 162
Jeanne K. DuShane, Michael P. Wilczek, Colleen L. Mayberry, Melissa S. Maginnis, and Lawrence Banks
Journal of Virology, 2018, Volume 92, Number 7, Page e01529-17
Victoria A. Meliopoulos, Lauren E. Andersen, Katherine F. Birrer, Kaylene J. Simpson, John W. Lowenthal, Andrew G. D. Bean, John Stambas, Cameron R. Stewart, S. Mark Tompkins, Victor W. van Beusechem, Iain Fraser, Musa Mhlanga, Samantha Barichievy, Queta Smith, Devin Leake, Jon Karpilow, Amy Buck, Ghil Jona, and Ralph A. Tripp
The FASEB Journal, 2012, Volume 26, Number 4, Page 1372
Ivana Colao, Rosamaria Pennisi, Assunta Venuti, Michaela Nygårdas, Outi Heikkilä, Veijo Hukkanen, and Maria Teresa Sciortino
Scientific Reports, 2017, Volume 7, Number 1
Hao Duan, Meng Zhu, Qing Xiong, Yuya Wang, Chao Xu, Jing Sun, Chao Wang, Hao Zhang, Ping Xu, and Yihong Peng
Antiviral Research, 2017, Volume 143, Page 13
Georgetta Cannon, Michelle A. Callahan, Jenny Q. Gronemus, R. Joel Lowy, and Andrew Pekosz
PLoS ONE, 2014, Volume 9, Number 8, Page e105385
Grégory Caignard, Anastassia V. Komarova, Mehdi Bouraï, Thomas Mourez, Yves Jacob, Louis M. Jones, Flore Rozenberg, Astrid Vabret, François Freymuth, Frédéric Tangy, Pierre-Olivier Vidalain, and Christopher F. Basler
PLoS Pathogens, 2009, Volume 5, Number 9, Page e1000587
Aaron Yun Chen, Steve Kleiboeker, Jianming Qiu, and Colin Parrish
PLoS Pathogens, 2011, Volume 7, Number 6, Page e1002088
Abhijeet Bakre, Lauren E. Andersen, Victoria Meliopoulos, Keegan Coleman, Xiuzhen Yan, Paula Brooks, Jackelyn Crabtree, S. Mark Tompkins, Ralph A. Tripp, and Dong-Yan Jin
PLoS ONE, 2013, Volume 8, Number 6, Page e66796
Teneema Kuriakose, Ralph A. Tripp, Wendy T. Watford, and Paul G. Thomas
PLOS Pathogens, 2015, Volume 11, Number 8, Page e1005038
Liqian Zhu, Chen Yuan, Liyuan Huang, Xiuyan Ding, Jianye Wang, Dong Zhang, and Guoqiang Zhu
Veterinary Research, 2016, Volume 47, Number 1
Hoi-Hin Kwok, Po-Ying Poon, Siu-Ping Fok, Patrick Ying-Kit Yue, Nai-Ki Mak, Michael Chi-Wai Chan, Joseph Sriyal Malik Peiris, and Ricky Ngok-Shun Wong
Scientific Reports, 2016, Volume 6, Number 1
Meng Zhu, Hao Duan, Meng Gao, Hao Zhang, and Yihong Peng
Viruses, 2015, Volume 7, Number 3, Page 1344
Kelsey Voss, Moushimi Amaya, Claudius Mueller, Brian Roberts, Kylene Kehn-Hall, Charles Bailey, Emanuel Petricoin, and Aarthi Narayanan
Virology, 2014, Volume 468-470, Page 490
Florencia N. Linero, Claudia S. Sepúlveda, Federico Giovannoni, Viviana Castilla, Cybele C. García, Luis A. Scolaro, and Elsa B. Damonte
Viruses, 2012, Volume 4, Number 12, Page 1569
Meng Gao, Hao Duan, Jing Liu, Hao Zhang, Xin Wang, Meng Zhu, Jitao Guo, Zhenlong Zhao, Lirong Meng, and Yihong Peng
Antiviral Research, 2014, Volume 106, Page 80
M. E. Rodriguez, J. E. Brunetti, M. B. Wachsman, L. A. Scolaro, and V. Castilla
Journal of General Virology, 2014, Volume 95, Number Pt_4, Page 799
X. Liu, Y. Yang, M. Zhao, L. Bode, L. Zhang, J. Pan, L. Lv, Y. Zhan, S. Liu, L. Zhang, X. Wang, R. Huang, J. Zhou, and P. Xie
Neuroscience, 2014, Volume 268, Page 284
Xue Wang, Jiying Tan, Olga Zoueva, Jiangqin Zhao, Zhiping Ye, and Indira Hewlett
Microbes and Infection, 2014, Volume 16, Number 3, Page 178
Benoît de Chassey, Laurène Meyniel-Schicklin, Anne Aublin-Gex, Vincent Navratil, Thibaut Chantier, Patrice André, and Vincent Lotteau
EMBO reports, 2013, Volume 14, Number 10, Page 938
Emanuel Haasbach, Carmen Hartmayer, and Oliver Planz
Antiviral Research, 2013, Volume 98, Number 2, Page 319
Nicolás I Torres, Viviana Castilla, and Mónica Wachsman
Future Virology, 2012, Volume 7, Number 11, Page 1115
Rajagopal N. Aravalli, Erik N. K. Cressman, and Clifford J. Steer
Archives of Toxicology, 2013, Volume 87, Number 2, Page 227
Almudena Laliena, Beatriz San Miguel, Irene Crespo, Marcelino Alvarez, Javier González-Gallego, and María J. Tuñón
Journal of Pineal Research, 2012, Volume 53, Number 3, Page 270
Bo Wang, Hao Zhang, Meng Zhu, Zhijun Luo, and Yihong Peng
Antiviral Research, 2012, Volume 93, Number 1, Page 110
Leila Gangehei, Muzammil Ali, Wei Zhang, Zhenping Chen, Koji Wakame, and Mehran Haidari
Phytomedicine, 2010, Volume 17, Number 13, Page 1047
Karoline Droebner, Stephan Pleschka, Stephan Ludwig, and Oliver Planz
Antiviral Research, 2011, Volume 92, Number 2, Page 195
Ruth Pinto, Susanne Herold, Lidija Cakarova, Katrin Hoegner, Jürgen Lohmeyer, Oliver Planz, and Stephan Pleschka
Antiviral Research, 2011, Volume 92, Number 1, Page 45
Christina Ehrhardt
Future Virology, 2011, Volume 6, Number 10, Page 1225
C. A. Maeto, M. E. Knott, F. N. Linero, P. C. Ellenberg, L. A. Scolaro, and V. Castilla
Journal of General Virology, 2011, Volume 92, Number 9, Page 2181
Pierre-Olivier Vidalain and Frédéric Tangy
Microbes and Infection, 2010, Volume 12, Number 14-15, Page 1134
Stephan Ludwig
Biological Chemistry, 2008, Volume 389, Number 10
Stephan Ludwig and Oliver Planz
Biological Chemistry, 2008, Volume 389, Number 10
XinXian Dai, LiShu Zhang, and Tao Hong
Science China Life Sciences, 2011, Volume 54, Number 1, Page 68
Oliver Planz, Stephan Pleschka, and Thorsten Wolff
Cellular Microbiology, 2009, Volume 11, Number 6, Page 872

Comments (0)

Please log in or register to comment.
Log in