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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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1437-4315
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Volume 389, Issue 10

Issues

Influenza viruses and the NF-κB signaling pathway – towards a novel concept of antiviral therapy

Stephan Ludwig
  • 1Institute of Molecular Virology (IMV), Westfaelische Wilhelms University, Von-Esmarch Str. 56, D-48161 Münster, Germany
  • Other articles by this author:
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/ Oliver Planz
  • 2Institute of Immunology, Friedrich-Löffler-Institute (FLI), Paul-Ehrlich Str. 28, D-72076 Tübingen, Germany
  • Other articles by this author:
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Published Online: 2008-08-19 | DOI: https://doi.org/10.1515/BC.2008.148

Abstract

Influenza A virus remains a major public health concern, both in its annual toll in death and debilitation and its potential to cause devastating pandemics. Like any other virus, influenza A viruses are strongly dependent on cellular factors for replication. One of the hallmark signaling factors activated by viral pathogens is the transcription factor NF-κB. Activation of NF-κB leads to the up-regulation of a variety of antiviral genes. Thus, the factor is commonly regarded as a major regulator of the innate immune defense to infection. However, several recent studies indicate that influenza viruses have acquired the capability to reprogram this antiviral activity and to exploit the factor for efficient replication. These data provide novel insights into the pathophysiological function of NF-κB in the special environment of a virus-infected cell. Furthermore, the unexpected viral dependency on a cellular signaling factor may pave the path for novel antiviral approaches targeting essential cellular components rather than viral factors.

Keywords: antiviral therapy; apoptosis; caspase; influenza virus; interferon response; NF-κB; signal transduction

About the article

Corresponding author


Received: 2008-03-31

Accepted: 2008-06-25

Published Online: 2008-08-19

Published in Print: 2008-10-01


Citation Information: Biological Chemistry, Volume 389, Issue 10, Pages 1307–1312, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.148.

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