Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

See all formats and pricing
More options …
Volume 389, Issue 10


Influenza viruses and the NF-κB signaling pathway – towards a novel concept of antiviral therapy

Stephan Ludwig
  • 1Institute of Molecular Virology (IMV), Westfaelische Wilhelms University, Von-Esmarch Str. 56, D-48161 Münster, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Oliver Planz
  • 2Institute of Immunology, Friedrich-Löffler-Institute (FLI), Paul-Ehrlich Str. 28, D-72076 Tübingen, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-08-19 | DOI: https://doi.org/10.1515/BC.2008.148


Influenza A virus remains a major public health concern, both in its annual toll in death and debilitation and its potential to cause devastating pandemics. Like any other virus, influenza A viruses are strongly dependent on cellular factors for replication. One of the hallmark signaling factors activated by viral pathogens is the transcription factor NF-κB. Activation of NF-κB leads to the up-regulation of a variety of antiviral genes. Thus, the factor is commonly regarded as a major regulator of the innate immune defense to infection. However, several recent studies indicate that influenza viruses have acquired the capability to reprogram this antiviral activity and to exploit the factor for efficient replication. These data provide novel insights into the pathophysiological function of NF-κB in the special environment of a virus-infected cell. Furthermore, the unexpected viral dependency on a cellular signaling factor may pave the path for novel antiviral approaches targeting essential cellular components rather than viral factors.

Keywords: antiviral therapy; apoptosis; caspase; influenza virus; interferon response; NF-κB; signal transduction

About the article

Corresponding author

Received: 2008-03-31

Accepted: 2008-06-25

Published Online: 2008-08-19

Published in Print: 2008-10-01

Citation Information: Biological Chemistry, Volume 389, Issue 10, Pages 1307–1312, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.148.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Lin Chen, Chao Xing, Guoyao Ma, Jing Luo, Wen Su, Meng Li, Qiumei Shi, and Hongxuan He
Virus Research, 2018
Haiyan Zhu, Xiaoxiao Lu, Lijun Ling, Hong Li, Yingye Ou, Xunlong Shi, Yan Lu, Yunyi Zhang, and Daofeng Chen
Journal of Ethnopharmacology, 2018
Javier Canton, Anthony R. Fehr, Raúl Fernandez-Delgado, Francisco J. Gutierrez-Alvarez, Maria T. Sanchez-Aparicio, Adolfo García-Sastre, Stanley Perlman, Luis Enjuanes, Isabel Sola, and Christopher F. Basler
PLOS Pathogens, 2018, Volume 14, Number 1, Page e1006838
Dony Mathew and Wei-Li Hsu
Journal of Functional Foods, 2018, Volume 40, Page 692
Karoline Droebner, Emanuel Haasbach, Sabine E. Dudek, Gerhard Scheuch, Karlheinz Nocker, Sebastian Canisius, Christina Ehrhardt, Georges von Degenfeld, Stephan Ludwig, and Oliver Planz
Frontiers in Microbiology, 2017, Volume 8
Ying Zhou, Shan Jiang, Kar Yan Li, Edward Chin Man Lo, and Xiaoli Gao
International Dental Journal, 2017
Georgetta Cannon, Michelle A. Callahan, Jenny Q. Gronemus, R. Joel Lowy, and Andrew Pekosz
PLoS ONE, 2014, Volume 9, Number 8, Page e105385
Abhijeet Bakre, Lauren E. Andersen, Victoria Meliopoulos, Keegan Coleman, Xiuzhen Yan, Paula Brooks, Jackelyn Crabtree, S. Mark Tompkins, Ralph A. Tripp, and Dong-Yan Jin
PLoS ONE, 2013, Volume 8, Number 6, Page e66796
Martin Michaelis, Janina Geiler, Patrizia Naczk, Patchima Sithisarn, Anke Leutz, Hans Wilhelm Doerr, Jindrich Cinatl, and Andrew Pekosz
PLoS ONE, 2011, Volume 6, Number 5, Page e19705
Dang Wang, Lu Cao, Zheng Xu, Liurong Fang, Yao Zhong, Quangang Chen, Rui Luo, Huanchun Chen, Kui Li, Shaobo Xiao, and Shuhong Zhao
PLoS ONE, 2013, Volume 8, Number 2, Page e55838
Lingbao Kong, Shanshan Li, Mingjie Huang, Ying Xiong, Qinghua Zhang, Li Ye, Jing Liu, Xiangdong Zhu, Ruina Sun, Yunli Guo, and Naglaa H. Shoukry
PLOS ONE, 2015, Volume 10, Number 4, Page e0123190
Ibrahim El-Sayed, Khalid Bassiouny, Aziz Nokaly, Ahmed S. Abdelghani, and Wael Roshdy
Biochemistry Research International, 2016, Volume 2016, Page 1
Jun-Da Zhu, Wen Meng, Xiao-Jia Wang, and Hwa-Chain R. Wang
Frontiers in Microbiology, 2015, Volume 6
Luis A Santos, Susana Solá, Cecilia MP Rodrigues, and Helena Rebelo-de-Andrade
Virus Research, 2015, Volume 205, Page 33
Hong-ping Hao, Li-bin Wen, Jia-rong Li, Yue Wang, Bo Ni, Rui Wang, Xin Wang, Ming-xia Sun, Hong-jie Fan, and Xiang Mao
Antiviral Research, 2015, Volume 117, Page 99
Stephan Ludwig, Roland Zell, Martin Schwemmle, and Susanne Herold
International Journal of Medical Microbiology, 2014, Volume 304, Number 7, Page 894
E. M. Vela, M. D. Kasoji, M. Q. Wendling, J. A. Price, K. A. B. Knostman, H. S. Bresler, and J. P. Long
Journal of Medical Microbiology, 2014, Volume 63, Number Pt_9, Page 1131
Katrin Bohm, Lijing Sun, Divyeshsinh Thakor, and Manfred Wirth
Virology, 2014, Volume 462-463, Page 241
Jingjing Xie, Shouping Zhang, Yanxin Hu, Dirui Li, Jingmin Cui, Jia Xue, Guozhong Zhang, Levon M. Khachigian, Jonathan Wong, Lunquan Sun, and Ming Wang
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014, Volume 1842, Number 12, Page 2479
Jun-Lin Ou, Yoshiyuki Mizushina, Sheng-Yang Wang, Duen-Yau Chuang, Muthukumar Nadar, and Wei-Li Hsu
FEBS Journal, 2013, Volume 280, Number 22, Page 5829
Emanuel Haasbach, Sarah Julia Reiling, Christina Ehrhardt, Karoline Droebner, Andrea Rückle, Eike R. Hrincius, Johann Leban, Stefan Strobl, Daniel Vitt, Stephan Ludwig, and Oliver Planz
Antiviral Research, 2013, Volume 99, Number 3, Page 336
Tufária Mussá, Maria Ballester, Erika Silva-Campa, Massimiliano Baratelli, Núria Busquets, Marie-Pier Lecours, Javier Dominguez, Massimo Amadori, Lorenzo Fraile, Jesús Hernández, and María Montoya
Veterinary Immunology and Immunopathology, 2013, Volume 154, Number 1-2, Page 25
Emanuel Haasbach, Carmen Hartmayer, and Oliver Planz
Antiviral Research, 2013, Volume 98, Number 2, Page 319
Shijuan Gao, Liping Song, Jiandong Li, Zhenzhu Zhang, Haiyan Peng, Wei Jiang, Qingtao Wang, Tiebang Kang, Shuai Chen, and Wenlin Huang
Cellular Microbiology, 2012, Volume 14, Number 12, Page 1849
Janina Geiler, Martin Michaelis, Patrizia Naczk, Anke Leutz, Klaus Langer, Hans-Wilhelm Doerr, and Jindrich Cinatl
Biochemical Pharmacology, 2010, Volume 79, Number 3, Page 413
J.G. Diaz Ochoa, A. Voigt, H. Briesen, and K. Sundmacher
Chemical Engineering Science, 2011, Volume 66, Number 17, Page 3954
Leila Gangehei, Muzammil Ali, Wei Zhang, Zhenping Chen, Koji Wakame, and Mehran Haidari
Phytomedicine, 2010, Volume 17, Number 13, Page 1047
Karoline Droebner, Stephan Pleschka, Stephan Ludwig, and Oliver Planz
Antiviral Research, 2011, Volume 92, Number 2, Page 195
Jessica A. Belser, Cynthia B. Snider, Nancy J. Cox, and Frederick G. Hayden
Influenza and Other Respiratory Viruses, 2011, Volume 5, Number 6, Page 443
Munishikha Kalia and Andreas Kukol
Journal of Structural Biology, 2011, Volume 176, Number 2, Page 133
Emanuel Haasbach, Eva-Katharina Pauli, Robert Spranger, David Mitzner, Ulrich Schubert, Ralf Kircheis, and Oliver Planz
Antiviral Research, 2011, Volume 91, Number 3, Page 304
Lyna Zhang, Jacqueline M. Katz, Marta Gwinn, Nicole F. Dowling, and Muin J. Khoury
Infection, Genetics and Evolution, 2009, Volume 9, Number 6, Page 1148
Young-Jin Seo, Stephen Alexander, and Bumsuk Hahm
Cytokine & Growth Factor Reviews, 2011, Volume 22, Number 1, Page 55
Jenish R. Patel, Keyur P. Vora, Shashank Tripathi, Hui Zeng, Terrence M. Tumpey, Jacqueline M. Katz, Suryaprakash Sambhara, and Shivaprakash Gangappa
Viral Immunology, 2011, Volume 24, Number 2, Page 89
Karoline Droebner, Bettina Klein, Stephan Paxian, Roland Schmid, Lothar Stitz, and Oliver Planz
Viral Immunology, 2010, Volume 23, Number 3, Page 295
Stephan Ludwig
Biological Chemistry, 2008, Volume 389, Number 10
Thorsten Wolff, Florian Zielecki, Marion Abt, Daniel Voss, Ilia Semmler, and Markus Matthaei
Biological Chemistry, 2008, Volume 389, Number 10
Stephan Pleschka
Biological Chemistry, 2008, Volume 389, Number 10
T. Shiozaki, A. Iwai, Y. Kawaoka, A. Takada, H. Kida, and T. Miyazaki
Journal of General Virology, 2011, Volume 92, Number 2, Page 315
S. Ludwig
Journal of Antimicrobial Chemotherapy, 2009, Volume 64, Number 1, Page 1

Comments (0)

Please log in or register to comment.
Log in