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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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Volume 389, Issue 11


Nitric oxide and sphingolipids: mechanisms of interaction and role in cellular pathophysiology

Cristiana Perrotta / Clara De Palma / Emilio Clementi
  • 3E. Medea Scientific Institute, I-23842 Bosisio Parini, and Department of Preclinical Sciences, University of Milano, I-20157 Milano, Italy
  • Other articles by this author:
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Published Online: 2008-09-11 | DOI: https://doi.org/10.1515/BC.2008.155


Nitric oxide is a short-lived messenger with pleiotropic roles in the regulation of cell patho-physiological processes, including survival, death, proliferation and differentiation. Increasing evidence over the last few years has shown that nitric oxide effects in apoptosis, growth and differentiation originate in significant part from its interplay with signalling members of the sphingolipid family. In many cell types belonging to different lineages, nitric oxide and sphingolipids interact in two-way pathways leading to regulation of the activity and expression of enzymes involved in each other's signalling events. These crosstalk signalling events involve various sphingolipids, with key roles for ceramide and sphingosine-1-phosphate, and signal transduction molecules downstream of nitric oxide, with cyclic GMP as a main player. The biological implications of some of these interactions are now being understood. The best-characterised so far, the mutual regulation of sphingomyelinases and endothelial nitric oxide synthase, acts as a tuning system in crucial patho-physiological processes such as inflammation, proliferation and cell death.

Keywords: apoptosis; ceramide; cyclic GMP; inflammation; nitric oxide; sphingomyelinases; sphingosine-1-phosphate

About the article

Corresponding author

Received: 2008-06-27

Accepted: 2008-07-22

Published Online: 2008-09-11

Published in Print: 2008-11-01

Citation Information: Biological Chemistry, Volume 389, Issue 11, Pages 1391–1397, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.155.

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