Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

See all formats and pricing



Select Volume and Issue


Nitric oxide and sphingolipids: mechanisms of interaction and role in cellular pathophysiology

Cristiana Perrotta1 / Clara De Palma2 / Emilio Clementi3

1Stem Cell Research Institute, San Raffaele Scientific Institute, I-20132 Milano, Italy

2Stem Cell Research Institute, San Raffaele Scientific Institute, I-20132 Milano, Italy

3E. Medea Scientific Institute, I-23842 Bosisio Parini, and Department of Preclinical Sciences, University of Milano, I-20157 Milano, Italy

Corresponding author

Citation Information: Biological Chemistry. Volume 389, Issue 11, Pages 1391–1397, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2008.155, September 2008

Publication History

Published Online:


Nitric oxide is a short-lived messenger with pleiotropic roles in the regulation of cell patho-physiological processes, including survival, death, proliferation and differentiation. Increasing evidence over the last few years has shown that nitric oxide effects in apoptosis, growth and differentiation originate in significant part from its interplay with signalling members of the sphingolipid family. In many cell types belonging to different lineages, nitric oxide and sphingolipids interact in two-way pathways leading to regulation of the activity and expression of enzymes involved in each other's signalling events. These crosstalk signalling events involve various sphingolipids, with key roles for ceramide and sphingosine-1-phosphate, and signal transduction molecules downstream of nitric oxide, with cyclic GMP as a main player. The biological implications of some of these interactions are now being understood. The best-characterised so far, the mutual regulation of sphingomyelinases and endothelial nitric oxide synthase, acts as a tuning system in crucial patho-physiological processes such as inflammation, proliferation and cell death.

Keywords: apoptosis; ceramide; cyclic GMP; inflammation; nitric oxide; sphingomyelinases; sphingosine-1-phosphate

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Isabelle Guillas, Amira Guellim, Nathalie Rezé, and Emmanuel Baudouin
Plant Physiology and Biochemistry, 2013, Volume 63, Page 191
Paolo Ascenzi, Roberto Santucci, Massimo Coletta, and Fabio Polticelli
Biophysical Chemistry, 2010, Volume 152, Number 1-3, Page 21
Jean-Philip Truman, Mohammed M. Al Gadban, Kent J. Smith, and Samar M. Hammad
Cellular and Molecular Life Sciences, 2011, Volume 68, Number 20, Page 3293
Syed M. Qadri, Julia Bauer, Christine Zelenak, Hasan Mahmud, Yuliya Kucherenko, Seung Hun Lee, Klaus Ferlinz, and Florian Lang
Cellular Physiology and Biochemistry, 2011, Volume 28, Number 2, Page 339
José MC Ribeiro, Jennifer M Anderson, Nicholas C Manoukis, Zhaojing Meng, and Ivo MB Francischetti
BMC Genomics, 2011, Volume 12, Number 1, Page 136
Erich Gulbins
Biological Chemistry, 2008, Volume 389, Number 11
Nguyen Thi Xuan, Ekaterina Shumilina, Erich Gulbins, Shuchen Gu, Friedrich Götz, and Florian Lang
Molecular Nutrition & Food Research, 2010, Volume 54, Number S2, Page S214
Nguyen Thi Xuan, Ekaterina Shumilina, Evi Schmid, Shefalee K. Bhavsar, Rexhep Rexhepaj, Friedrich Götz, Erich Gulbins, and Florian Lang
Molecular Nutrition & Food Research, 2010, Volume 54, Number 12, Page 1833
Paolo Ascenzi, Alessandra di Masi, Clara Sciorati, and Emilio Clementi
BioFactors, 2010, Volume 36, Number 4, Page 264
Ekaterina Shumilina, Nguyen Thi Xuan, Evi Schmid, Shefalee K. Bhavsar, Kalina Szteyn, Shuchen Gu, Friedrich Götz, and Florian Lang
Apoptosis, 2010, Volume 15, Number 10, Page 1177
N. Maugeri, P. Rovere-Querini, M. Baldini, M. G. Sabbadini, and A. A. Manfredi
Clinical & Experimental Immunology, 2009, Volume 156, Number 3, Page 395

Comments (0)

Please log in or register to comment.