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Abstract
A range of various assays to measure chemosusceptibility of Plasmodium falciparum have been described in the literature. As the screening of a plethora of compounds for antiplasmodial activity is urgently needed and becomes a constantly increasing routine analysis, a test system has to fulfill the following requirements: sensitivity, reliability, simplicity of performance, high-throughput compatibility, and cost-effectiveness. Here, we describe an assay that fulfills all criteria and in which the fluorescent SYTOX® Green dye is introduced to determine growth inhibition of Plasmodia in in vitro cultures.
Received: 2008-7-13
Accepted: 2008-8-26
Published Online: 2008-10-09
Published in Print: 2008-12-01
©2008 by Walter de Gruyter Berlin New York