Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

See all formats and pricing



Select Volume and Issue


Reflections on the tissue kallikrein and kallikrein-related peptidase family – from mice to men – what have we learnt in the last two decades?

Judith A. Clements1

1Hormone Dependent Cancer Program, Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Brisbane 4059, QLD, Australia

Citation Information: Biological Chemistry. Volume 389, Issue 12, Pages 1447–1454, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2008.174, October 2008

Publication History

Published Online:


The genes encoding the kininogenase, glandular tissue kallikrein, in rodents and man were first described in the mid-1980s. Remarkably, they appeared to be part of a much larger highly conserved family of genes (GK) in rodents, but only had two paralogs in man. This discrepancy was not rectified until the late 1990s/2000 with the identification of a cluster of 12 more kallikrein-related (KLK) genes in the human 19q13 locus and the subsequent identification of their rodent homologs. Interestingly, there are remarkable similarities in expression patterns, hormonal regulation and functional attributes of the old (GK) and new (KLK) families which underscore the evolutionary conservation across these loci and species. This historical perspective focuses on the lessons learned from earlier studies on the rodent GK gene families and the striking similarities of some attributes, yet uniqueness, of others. These earlier findings have all contributed to the current status of the KLK serine peptidase-encoding gene family as an exciting source of new biomarkers and therapeutic targets.

Keywords: expression; function; gene clusters; glandular kallikrein (GK); hormonal regulation; kallikrein-related (KLK)

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Arije Ghannam, Federica Defendi, Delphine Charignon, Françoise Csopaki, Bertrand Favier, Mohammed Habib, Sven Cichon, and Christian Drouet
Immunology and Allergy Clinics of North America, 2013, Volume 33, Number 4, Page 513
M. Schmitt, T. Renné, and A. Scorilas
Thrombosis and Haemostasis, 2013, Volume 110, Number 3, Page 396
L. Waeckel, L. Potier, C. Richer, R. Roussel, N. Bouby, and F. Alhenc-Gelas
Thrombosis and Haemostasis, 2013, Volume 110, Number 3, Page 476
Daniela Loessner, Verena M.C. Quent, Julia Kraemer, Eva C. Weber, Dietmar W. Hutmacher, Viktor Magdolen, and Judith A. Clements
Gynecologic Oncology, 2012, Volume 127, Number 3, Page 569
Lloyd D. Fricker
Colloquium Series on Neuropeptides, 2012, Volume 1, Number 3, Page 1
Jane Bayani and Eleftherios P. Diamandis
Clinical Chemistry and Laboratory Medicine (CCLM), 2012, Volume 50, Number 2
Sadao Shiosaka and Yasuyuki Ishikawa
Journal of Chemical Neuroanatomy, 2011, Volume 42, Number 1, Page 24
Antoni Stadnicki
Inflammatory Bowel Diseases, 2011, Volume 17, Number 2, Page 645
Daniel J. Sexton, Ting Chen, Diana Martik, Petr Kuzmic, Guannan Kuang, Jie Chen, Andrew E. Nixon, Bruce L. Zuraw, Rosanna M. Forteza, William M. Abraham, and Clive R. Wood
Biochemical Journal, 2009, Volume 422, Number 2, Page 383

Comments (0)

Please log in or register to comment.