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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

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Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence

Kotb Abdelmohsen1 / Yuki Kuwano2 / Hyeon Ho Kim3 / Myriam Gorospe4

1Laboratory of Cellular and Molecular Biology, National Institute on Aging – Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA

2Laboratory of Cellular and Molecular Biology, National Institute on Aging – Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA

3Laboratory of Cellular and Molecular Biology, National Institute on Aging – Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA

4Laboratory of Cellular and Molecular Biology, National Institute on Aging – Intramural Research Program, National Institutes of Health, Baltimore, MD 21228, USA

Corresponding author

Citation Information: Biological Chemistry. Volume 389, Issue 3, Pages 243–255, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: 10.1515/BC.2008.022, March 2008

Publication History

Published Online:


To respond adequately to oxidative stress, mammalian cells elicit rapid and tightly controlled changes in gene expression patterns. Besides alterations in the subsets of transcribed genes, two posttranscriptional processes prominently influence the oxidant-triggered gene expression programs: mRNA turnover and translation. Here, we review recent progress in our knowledge of the turnover and translation regulatory (TTR) mRNA-binding proteins (RBPs) that influence gene expression in response to oxidative damage. Specifically, we identify oxidant damage-regulated mRNAs that are targets of TTR-RBPs, we review the oxidant-triggered signaling pathways that govern TTR-RBP function, and we examine emerging evidence that TTR-RBP activity is altered with senescence and aging. Given the potent influence of TTR-RBPs upon oxidant-regulated gene expression profiles, we propose that the senescence-associated changes in TTR-RBPs directly contribute to the impaired responses to oxidant damage that characterize cellular senescence and advancing age.

Keywords: mRNA stability; posttranscriptional gene regulation; reactive oxygen species (ROS) signaling pathway; RNA-binding proteins; translational control

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