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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

Online
ISSN
1437-4315
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Volume 389, Issue 3

Issues

New biological activity against phospholipase A2 by Turmerin, a protein from Curcuma longa L.

Mukunda Chethankumar
  • 1Adichunchanagiri Biotechnology and Cancer Research Institute, Balagangadharanatha Nagara, 571 448 Mandya, Karnataka, India
  • Other articles by this author:
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/ Leela Srinivas
  • 2Adichunchanagiri Biotechnology and Cancer Research Institute, Balagangadharanatha Nagara, 571 448 Mandya, Karnataka, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-03-03 | DOI: https://doi.org/10.1515/BC.2008.024

Abstract

Turmerin is a protein from Turmeric (Curcuma longa L.) with a relative molecular mass of 14 kDa. The protein inhibits the enzymatic activity and neutralises the pharmacological properties, such as cytotoxicity, oedema and myotoxicity of multitoxic phospholipase A2 (NV-PLA2) of cobra (Naja naja) venom at a 1:2.5 molar ratio of NV-PLA2:Turmerin. A Lineweaver-Burk plot indicates that Turmerin follows a linear mixed type of inhibition.

Keywords: cytotoxicity; myotoxicity; Naja naja phospholipase A2; oedema; Turmerin

About the article

Corresponding author


Received: 2007-09-04

Accepted: 2007-11-20

Published Online: 2008-03-03

Published in Print: 2008-03-01


Citation Information: Biological Chemistry, Volume 389, Issue 3, Pages 299–303, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2008.024.

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