Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

IMPACT FACTOR 2018: 3.014
5-year IMPACT FACTOR: 3.162

CiteScore 2018: 3.09

SCImago Journal Rank (SJR) 2018: 1.482
Source Normalized Impact per Paper (SNIP) 2018: 0.820

See all formats and pricing
More options …
Volume 389, Issue 3


Modulation of longevity-associated genes by estrogens or phytoestrogens

Jose Viña / Juan Sastre / Federico V. Pallardó / Juan Gambini / Consuelo Borrás
  • 5Fundación Investigación Hospital Clínico Universitario de Valencia, E-46010 Valencia, Spain
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-03-03 | DOI: https://doi.org/10.1515/BC.2008.027


Females live longer than males. We have shown that the higher levels of estrogens in females protect them against aging, by up-regulating the expression of antioxidant, longevity-related genes, such as that of selenium-dependent glutathione peroxidase (GPx) and Mn-superoxide dismutase (Mn-SOD). Both estradiol and genistein (the most abundant phytoestrogen in soybeans) share chemical properties which confer antioxidant features to these compounds. However, the low concentration of estrogens and phytoestrogens make it unlikely that they exhibit significant antioxidant capacity in the organism. Physiological concentrations of estrogens and nutritionally relevant concentrations of genistein activate the MAP kinase pathway. These, in turn, activate the nuclear factor kappa B (NF-κB) signaling pathway. Activation of NF-κB by estrogens subsequently activates the expression of Mn-SOD and GPx, but genistein is only capable of activating Mn-SOD expression. This could be due to the fact that genistein binds preferably to estrogen receptor β. The antioxidant protection is reflected in the lower peroxide levels found in cells treated with estrogens or phytoestrogens when compared with controls. The challenge for the future is to find molecules that have the beneficial effects of estradiol, but without its feminizing effects. Phytoestrogens or phytoestrogen-related molecules may be good candidates to meet this challenge.

Keywords: aging; antioxidant enzymes; estrogenic compounds; free radicals; gender; oxidative stress

About the article

Corresponding author

Published Online: 2008-03-03

Published in Print: 2008-03-01

Citation Information: Biological Chemistry, Volume 389, Issue 3, Pages 273–277, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2008.027.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Jian-Ming Lü, Jun Jiang, Md Jamaluddin, Zhengdong Liang, Qizhi Yao, and Changyi Chen
International Journal of Molecular Sciences, 2019, Volume 20, Number 2, Page 294
C. Silaidos, U. Pilatus, R. Grewal, S. Matura, B. Lienerth, J. Pantel, and G. P. Eckert
Biology of Sex Differences, 2018, Volume 9, Number 1
Nandor Gabor Than, Roberto Romero, Adi L. Tarca, Sorin Draghici, Offer Erez, Tinnakorn Chaiworapongsa, Yeon Mee Kim, Sun Kwon Kim, Edi Vaisbuch, and Gerard Tromp
The Journal of Maternal-Fetal & Neonatal Medicine, 2009, Volume 22, Number 11, Page 1000
M Szczubial, M Kankofer, M Bochniarz, and R Dąbrowski
Reproduction in Domestic Animals, 2015, Volume 50, Number 3, Page 393
Saradha Iragavarapu and Michael B. Gorin
Current Eye Research, 2015, Volume 40, Number 2, Page 128
Jens Krøll
Rejuvenation Research, 2014, Volume 17, Number 2, Page 157
Malaika Fischer, Charlotte Regitz, Mareike Kahl, Michael Werthebach, Michael Boll, and Uwe Wenzel
Molecular Nutrition & Food Research, 2012, Volume 56, Number 6, Page 957
Volodymyr I. Lushchak
Journal of Amino Acids, 2012, Volume 2012, Page 1
Lian-wei Xu, Lan Kluwe, Ting-ting Zhang, Sheng-nan Li, Yan-yan Mou, Zhen Sang, Jun Ma, Xiong Lu, and Zhuo-jun Sun
BMC Complementary and Alternative Medicine, 2011, Volume 11, Number 1
Khaled HAMDEN, Serge CARREAU, Fatma AYADI, Hatem MASMOUDI, and Abdelfattah EL FEKI
Biomedical and Environmental Sciences, 2009, Volume 22, Number 5, Page 381
Deeba N. Syed and Hasan Mukhtar
Journal of Investigative Dermatology, 2012, Volume 132, Number 3, Page 512
Maria Helena Weber, Ricardo Fagundes da Rocha, Carlos Eduardo Schnorr, Rafael Schröder, and José Cláudio Fonseca Moreira
Journal of Physiology and Biochemistry, 2012, Volume 68, Number 3, Page 365
Raúl López-Grueso, Consuelo Borrás, Juan Gambini, and José Viña
Revista Española de Geriatría y Gerontología, 2010, Volume 45, Number 3, Page 136
Pardeep Kumar, R. K. Kale, and Najma Zaheer Baquer
Journal of Aging Research, 2011, Volume 2011, Page 1
I. Baeza, C. Alvarado, P. Álvarez, V. Salazar, C. Castillo, C. Ariznavarreta, J.A. Fdez-Tresguerres, and M. De la Fuente
Journal of Reproductive Immunology, 2009, Volume 80, Number 1-2, Page 70
Malgorzata Roszkowska-Gancarz, Alina Kurylowicz, Jacek Polosak, Michal Ambroziak, and Monika Puzianowska-Kuznicka
Clinica Chimica Acta, 2010, Volume 411, Number 23-24, Page 1883
A.M. Miró, J. Sastre-Serra, D.G. Pons, A. Valle, P. Roca, and J. Oliver
The Journal of Steroid Biochemistry and Molecular Biology, 2011, Volume 123, Number 3-5, Page 133
Guilherme Antônio Behr, Leonardo Lisbôa da Motta, Marcos Roberto de Oliveira, Max William Soares Oliveira, Mariana Leivas Müller Hoff, Roberta Bristot Silvestrin, and José Cláudio Fonseca Moreira
Behavioural Brain Research, 2009, Volume 199, Number 2, Page 263
Khaled Hamden, Bassem Jaouadi, Serge Carreau, Abdallah Aouidet, and Abdelfattah Elfeki
Natural Product Research, 2011, Volume 25, Number 3, Page 244
Isabel Baeza, Nuria M. De Castro, Lorena Arranz, Jesús Fdez-Tresguerres, and Mónica De la Fuente
Biogerontology, 2011, Volume 12, Number 3, Page 227
K. Hamden, S. Carreau, K. Jamoussi, F. Ayadi, F. Garmazi, N. Mezgenni, and A. Elfeki
Journal of Physiology and Biochemistry, 2008, Volume 64, Number 3, Page 231
Isabel Baeza, Nuria M. De Castro, Lorena Arranz, and Mónica De la Fuente
Rejuvenation Research, 2010, Volume 13, Number 6, Page 665
Khaled Hamden, Bassem Jaouadi, Nedia Zaraî, Tarek Rebai, Serge Carreau, and Abdelfattah Elfeki
Journal of Physiology and Biochemistry, 2011, Volume 67, Number 1, Page 121
R. M. Corbo, L. Ulizzi, L. Positano, and R. Scacchi
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2011, Volume 66A, Number 1, Page 51
V. A. Chistyakov, V. A. Serezhenkov, A. A. Alexandrova, N. P. Milyutina, V. N. Prokof’ev, E. V. Mashkina, L. V. Gutnikova, and S. V. Dem’yanenko
Biochemistry (Moscow), 2010, Volume 75, Number 11, Page 1383
W Chen, M Mempel, C Traidl-Hofmann, S Al Khusaei, and J Ring
Journal of the European Academy of Dermatology and Venereology, 2010, Volume 24, Number 12, Page 1378
Isabel Baeza, Jesús Fdez-Tresguerres, Carmen Ariznavarreta, and Mónica De la Fuente
Biogerontology, 2010, Volume 11, Number 6, Page 687
Dawn A. Lowe, Kristen A. Baltgalvis, and Sarah M. Greising
Exercise and Sport Sciences Reviews, 2010, Volume 38, Number 2, Page 61
G. A. Behr, L. L. da Motta, M. R. de Oliveira, M. W. S. Oliveira, D. P. Gelain, and J. C. F. Moreira
Chemical Senses, 2009, Volume 34, Number 4, Page 317
I. Margaritis and A. S. Rousseau
Nutrition Research Reviews, 2008, Volume 21, Number 01

Comments (0)

Please log in or register to comment.
Log in