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Thomas, Douglas D.

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

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Volume 389, Issue 4 (Apr 2008)

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The role of long non-coding RNAs in chromatin structure and gene regulation: variations on a theme

David Umlauf
  • 1Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
/ Peter Fraser
  • 2Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
/ Takashi Nagano
  • 3Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
Published Online: 2008-03-27 | DOI: https://doi.org/10.1515/BC.2008.047

Abstract

Transcriptome studies have uncovered a plethora of non-coding RNAs (ncRNA) in mammals. Most originate within intergenic regions of the genome and recent evidence indicates that some are involved in many different pathways that ultimately act on genome architecture and gene expression. In this review, we discuss the role of well-characterized long ncRNAs in gene regulation pointing to their similarities, but also their differences. We will attempt to highlight a paradoxical situation in which transcription is needed to repress entire chromosomal domains possibly through the action of ncRNAs that create nuclear environments refractory to transcription.

Keywords: histone modifications; nuclear organization; transcription; transcription factories

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Corresponding author


Published Online: 2008-03-27

Published in Print: 2008-04-01



Citation Information: Biological Chemistry, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2008.047. Export Citation

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