Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 389, Issue 4

Issues

The role of long non-coding RNAs in chromatin structure and gene regulation: variations on a theme

David Umlauf
  • 1Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Peter Fraser
  • 2Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Takashi Nagano
  • 3Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-03-27 | DOI: https://doi.org/10.1515/BC.2008.047

Abstract

Transcriptome studies have uncovered a plethora of non-coding RNAs (ncRNA) in mammals. Most originate within intergenic regions of the genome and recent evidence indicates that some are involved in many different pathways that ultimately act on genome architecture and gene expression. In this review, we discuss the role of well-characterized long ncRNAs in gene regulation pointing to their similarities, but also their differences. We will attempt to highlight a paradoxical situation in which transcription is needed to repress entire chromosomal domains possibly through the action of ncRNAs that create nuclear environments refractory to transcription.

Keywords: histone modifications; nuclear organization; transcription; transcription factories

About the article

Corresponding author


Published Online: 2008-03-27

Published in Print: 2008-04-01


Citation Information: Biological Chemistry, Volume 389, Issue 4, Pages 323–331, ISSN (Online) 14374315, ISSN (Print) 14316730, DOI: https://doi.org/10.1515/BC.2008.047.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Julie Mireille Joé Lepesant, Christoph Grunau, and Céline Cosseau
Memórias do Instituto Oswaldo Cruz, 2011, Volume 106, Number 7, Page 823
[2]
A.R. Ghanam, Qianlan Xu, Shengwei Ke, Muhammad Azhar, Qingyu Cheng, and Xiaoyuan Song
Aging and Disease, 2017, Volume 8, Number 2, Page 149
[3]
Yih-Horng Shiao, Sorin T. Lupascu, Yuhan D. Gu, Wojciech Kasprzak, Christopher J. Hwang, Janet R. Fields, Robert M. Leighty, Octavio Quiñones, Bruce A. Shapiro, W. Gregory Alvord, Lucy M. Anderson, and Anita Brandstaetter
PLoS ONE, 2009, Volume 4, Number 10, Page e7505
[4]
Qi Zhang, Mei-Mei Lai, Yun-Yan Lou, Bin-Han Guo, Hui-Yan Wang, and Xiao-Qun Zheng
Gene, 2016, Volume 594, Number 1, Page 144
[5]
Ryoma Yoneda, Yui Satoh, Ikuya Yoshida, Shohei Kawamura, Tomoya Kotani, and Atsushi P. Kimura
Molecular Reproduction and Development, 2016, Volume 83, Number 6, Page 541
[6]
Wei Zhao, Joseph Mazar, Bongyong Lee, Junko Sawada, Jian-Liang Li, John Shelley, Subramaniam Govindarajan, Dwight Towler, John S. Mattick, Masanobu Komatsu, Marcel E. Dinger, and Ranjan J. Perera
Journal of Investigative Dermatology, 2016, Volume 136, Number 4, Page 819
[7]
Teng Liu, Song-Ke Shen, Jian-Gui Xiong, Yuan Xu, Han-Qi Zhang, Hai-Jun Liu, and Zheng-Gen Lu
FEBS Open Bio, 2016, Volume 6, Number 2, Page 147
[8]
Kotb Abdelmohsen and Myriam Gorospe
Wiley Interdisciplinary Reviews: RNA, 2015, Volume 6, Number 6, Page 615
[9]
Tetsuo Hirano, Ryoko Yoshikawa, Hironori Harada, Yuka Harada, Atsuhiko Ishida, and Takeshi Yamazaki
Molecular Cancer, 2015, Volume 14, Number 1
[10]
HEE JUNG KIM, DAE WOO LEE, GA WON YIM, EUN JI NAM, SUNGHOON KIM, SANG WUN KIM, and YOUNG TAE KIM
International Journal of Oncology, 2015, Volume 46, Number 2, Page 521
[11]
Tiffany Hung and Howard Y. Chang
RNA Biology, 2010, Volume 7, Number 5, Page 582
[12]
Joseph Autuoro, Stephan Pirnie, and Gordon Carmichael
Biomolecules, 2014, Volume 4, Number 1, Page 76
[13]
Ezgi Hacisuleyman, Loyal A Goff, Cole Trapnell, Adam Williams, Jorge Henao-Mejia, Lei Sun, Patrick McClanahan, David G Hendrickson, Martin Sauvageau, David R Kelley, Michael Morse, Jesse Engreitz, Eric S Lander, Mitch Guttman, Harvey F Lodish, Richard Flavell, Arjun Raj, and John L Rinn
Nature Structural & Molecular Biology, 2014, Volume 21, Number 2, Page 198
[14]
J. M. Engreitz, A. Pandya-Jones, P. McDonel, A. Shishkin, K. Sirokman, C. Surka, S. Kadri, J. Xing, A. Goren, E. S. Lander, K. Plath, and M. Guttman
Science, 2013, Volume 341, Number 6147, Page 1237973
[15]
Matthew Gow, Dora Mirembe, Zaomba Longwe, and Benjamin S. Pickard
Journal of Cellular and Molecular Medicine, 2013, Volume 17, Number 5, Page 657
[16]
Müjdat Zeybel, Timothy Hardy, Yi K Wong, John C Mathers, Christopher R Fox, Agata Gackowska, Fiona Oakley, Alastair D Burt, Caroline L Wilson, Quentin M Anstee, Matt J Barter, Steven Masson, Ahmed M Elsharkawy, Derek A Mann, and Jelena Mann
Nature Medicine, 2012, Volume 18, Number 9, Page 1369
[17]
Maria Jesus Perugorria, Caroline L. Wilson, Mujdat Zeybel, Meagan Walsh, Shilu Amin, Stuart Robinson, Steven A. White, Alastair D. Burt, Fiona Oakley, Hidekazu Tsukamoto, Derek A. Mann, and Jelena Mann
Hepatology, 2012, Volume 56, Number 3, Page 1129
[18]
Yuan GAO, Ning HUI, and Shan-rong LIU
Academic Journal of Second Military Medical University, 2011, Volume 31, Number 7, Page 790
[19]
Feng Wang and Eric C. Greene
Journal of Molecular Biology, 2011, Volume 412, Number 5, Page 814
[20]
Radha Raman Pandey, Tanmoy Mondal, Faizaan Mohammad, Stefan Enroth, Lisa Redrup, Jan Komorowski, Takashi Nagano, Debora Mancini-DiNardo, and Chandrasekhar Kanduri
Molecular Cell, 2008, Volume 32, Number 2, Page 232
[21]
Kyoko L. Yap, Side Li, Ana M. Muñoz-Cabello, Selina Raguz, Lei Zeng, Shiraz Mujtaba, Jesús Gil, Martin J. Walsh, and Ming-Ming Zhou
Molecular Cell, 2010, Volume 38, Number 5, Page 662
[22]
Rémi Terranova, Shihori Yokobayashi, Michael B. Stadler, Arie P. Otte, Maarten van Lohuizen, Stuart H. Orkin, and Antoine H.F.M. Peters
Developmental Cell, 2008, Volume 15, Number 5, Page 668
[23]
Céline Cosseau, Abdelhalim Azzi, Kristina Smith, Michael Freitag, Guillaume Mitta, and Christoph Grunau
Molecular and Biochemical Parasitology, 2009, Volume 166, Number 1, Page 70
[24]
Joanne Whitehead, Gaurav Kumar Pandey, and Chandrasekhar Kanduri
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009, Volume 1790, Number 9, Page 936
[25]
J. L. Fernández-Morera, V. Calvanese, S. Rodríguez-Rodero, E. Menéndez-Torre, and M. F. Fraga
Tissue Antigens, 2010, Volume 76, Number 6, Page 431
[26]
Zhanquan Shi, Nadine Dragin, Marian L. Miller, Keith F. Stringer, Elisabet Johansson, Jing Chen, Shigeyuki Uno, Frank J. Gonzalez, Carlos A. Rubio, and Daniel W. Nebert
International Journal of Cancer, 2010, Volume 127, Number 10, Page 2334
[27]
Takashi Nagano and Peter Fraser
Mammalian Genome, 2009, Volume 20, Number 9-10, Page 557
[28]
Slim Kacem and Robert Feil
Mammalian Genome, 2009, Volume 20, Number 9-10, Page 544
[29]
Heather A. McQueen and Michael Clinton
Chromosome Research, 2009, Volume 17, Number 5, Page 687
[30]
T. Nagano, J. A. Mitchell, L. A. Sanz, F. M. Pauler, A. C. Ferguson-Smith, R. Feil, and P. Fraser
Science, 2008, Volume 322, Number 5908, Page 1717

Comments (0)

Please log in or register to comment.
Log in