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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2017: 3.022

CiteScore 2017: 2.81

SCImago Journal Rank (SJR) 2017: 1.562
Source Normalized Impact per Paper (SNIP) 2017: 0.705

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1437-4315
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Volume 389, Issue 5

Issues

Novel strategies to identify biomarkers in tuberculosis

Marc Jacobsen
  • Present address: Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, D-20359 Hamburg, Germany.
    1Max Planck Institute for Infection Biology, Department of Immunology, D-10117 Berlin, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Jens Mattow
  • 2Max Planck Institute for Infection Biology, Department of Immunology, D-10117 Berlin, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Dirk Repsilber
  • 3Research Institute for the Biology of Farm Animals, Genetics and Biometry, D-18196 Dummerstorf, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Stefan H.E. Kaufmann
  • 4Max Planck Institute for Infection Biology, Department of Immunology, D-10117 Berlin, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-03-27 | DOI: https://doi.org/10.1515/BC.2008.053

Abstract

The more we learn about the immune response against tuberculosis (TB) and particularly about the features which distinguish protective immunity, disease susceptibility and pathology, the better we can define biomarkers which correlate with these different stages of infection. The most widely used biomarker in TB, which without a doubt is an important component of protective immunity, is IFNγ secreted by antigen-specific CD4 T-cells. However, the complexity of the immune response against TB makes it more than likely that additional biomarkers are required for a reliable correlate of protection. As a corollary, we assume that a set of biomarkers will be required, termed a biosignature.

Keywords: antigen; biosignature; metabolomics; proteomics; T-cells; transcriptomics

About the article

Corresponding author


Published Online: 2008-03-27

Published in Print: 2008-05-01


Citation Information: Biological Chemistry, Volume 389, Issue 5, Pages 487–495, ISSN (Online) 14374315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.053.

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