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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

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Maintenance of serological memory

Jens Wrammert1 / Rafi Ahmed2

1Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA

2Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA

Corresponding author

Citation Information: Biological Chemistry. Volume 389, Issue 5, Pages 537–539, ISSN (Online) 14374315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.066, March 2008

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Long-lived plasma cells are key to maintaining long-term humoral immunity after infection or vaccination. Some vaccines and/or infections induce antibody levels that remain stable for the life of the individual. However, the mechanism whereby these long-lived plasma cells are maintained over long periods of time remains an open question. Furthermore, given a finite number of sustainable plasma cells within the bone marrow, it is also unclear how space for newly induced plasma cells is generated without compromising the pre-existing repertoire. Here we review the current understanding of these important issues.

Keywords: antibodies; humoral immunity; plasma cells; vaccination

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