Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred


SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

249,00 € / $374.00 / £187.00*

Online
ISSN
1437-4315
See all formats and pricing

 


 
 

Select Volume and Issue

Issues

30,00 € / $42.00 / £23.00

Get Access to Full Text

Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration

Isobel A. Scarisbrick1 / Rachel Linbo2 / Alexander G. Vandell3 / Mark Keegan4 / Sachiko I. Blaber5 / Michael Blaber6 / Diane Sneve7 / Claudia F. Lucchinetti8 / Moses Rodriguez9 / Eleftherios P. Diamandis10

1Program for Molecular Neuroscience, Mayo Clinic College of Medicine, Rochester, MN 55905, USA and Departments of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, MN 55905, USA and Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

2Departments of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

3Program for Molecular Neuroscience, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

4Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

5Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306-4300, USA

6Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306-4300, USA

7Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

8Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

9Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

10Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto M5G 1X5, Ontario, Canada

Corresponding author

Citation Information: Biological Chemistry. Volume 389, Issue 6, Pages 739–745, ISSN (Online) 14374315, ISSN (Print) 1431-6730, DOI: 10.1515/BC.2008.085, May 2008

Publication History

Received:
2007-11-30
Accepted:
2008-02-27
Published Online:
2008-05-15

Abstract

Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2–15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometric ELISA. Serum levels were then correlated with Expanded Disability Status Scale (EDSS) scores determined at the time of serological sampling or at last clinical follow-up. Serum levels of KLK1 and KLK6 were elevated in MS patients (p≤0.027), with highest levels associated with secondary progressive disease. Elevated KLK1 correlated with higher EDSS scores at the time of serum draw and KLK6 with future EDSS worsening in relapsing remitting patients (p≤0.007). Supporting the concept that KLK1 and KLK6 promote degenerative events associated with progressive MS, exposure of murine cortical neurons to either kallikrein promoted rapid neurite retraction and neuron loss. These novel findings suggest that KLK1 and KLK6 may serve as serological markers of progressive MS and contribute directly to the development of neurological disability by promoting axonal injury and neuron cell death.

Keywords: axon injury; kallikrein; prognosis; serine protease

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Faiz-ul-Hassan Nasim, Samina Ejaz, Muhammad Ashraf, and Gulzar Ahmad
Applied Immunohistochemistry & Molecular Morphology, 2016, Volume 24, Number 1, Page 64
[2]
Maja Radulovic, Hyesook Yoon, Jianmin Wu, Karim Mustafa, Michael G. Fehlings, and Isobel A. Scarisbrick
Neurobiology of Disease, 2015
[3]
Ann C. Kroksveen, Jill A. Opsahl, Astrid Guldbrandsen, Kjell-Morten Myhr, Eystein Oveland, Øivind Torkildsen, and Frode S. Berven
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2015, Volume 1854, Number 7, Page 746
[4]
Qing Zhao and Guangjie Chen
BioMed Research International, 2014, Volume 2014, Page 1
[5]
Andreas Scorilas and Konstantinos Mavridis
Expert Review of Molecular Diagnostics, 2014, Volume 14, Number 6, Page 713
[6]
Helen W. Phipps, Liam M. Longo, Sachiko I. Blaber, Michael Blaber, and Jacob W. VanLandingham
Brain Injury, 2013, Volume 27, Number 13-14, Page 1698
[7]
Joshua E. Burda, Maja Radulovic, Hyesook Yoon, and Isobel A. Scarisbrick
Glia, 2013, Volume 61, Number 9, Page 1456
[8]
Hyesook Yoon, Maja Radulovic, Jianmin Wu, Sachiko I. Blaber, Michael Blaber, Michael G. Fehlings, and Isobel A. Scarisbrick
Journal of Neurochemistry, 2013, Volume 127, Number 2, Page 283
[9]
Giuseppe Caliendo, Vincenzo Santagada, Elisa Perissutti, Beatrice Severino, Ferdinando Fiorino, Francesco Frecentese, and Luiz Juliano
Journal of Medicinal Chemistry, 2012, Volume 55, Number 15, Page 6669
[10]
Maroulio Talieri, Marita Zoma, Marina Devetzi, Andreas Scorilas, and Alexandros Ardavanis
Tumor Biology, 2012, Volume 33, Number 5, Page 1375
[11]
Isobel A. Scarisbrick, Hyesook Yoon, Michael Panos, Nadya Larson, Sachiko I. Blaber, Michael Blaber, and Moses Rodriguez
Brain Pathology, 2012, Volume 22, Number 5, Page 709
[12]
George P. Christophi, Ross C. Gruber, Michael Panos, Rebecca L. Christophi, Burk Jubelt, and Paul T. Massa
Clinical Immunology, 2012, Volume 142, Number 3, Page 308
[13]
Maroulio Talieri, Marina Devetzi, Andreas Scorilas, Eleana Pappa, Nikolaos Tsapralis, Ioannis Missitzis, and Alexandros Ardavanis
Tumor Biology, 2012, Volume 33, Number 4, Page 1075
[14]
Vaibhav Singh, Rogier Q. Hintzen, Theo M. Luider, and Marcel P. Stoop
Journal of Neuroimmunology, 2012, Volume 248, Number 1-2, Page 40
[15]
Jane Bayani and Eleftherios P. Diamandis
Clinical Chemistry and Laboratory Medicine (CCLM), 2012, Volume 50, Number 2
[16]
Joakim E. Swedberg, Simon J. de Veer, and Jonathan M. Harris
Biological Chemistry, 2010, Volume 391, Number 4
[17]
Violaine K. Harris, Andrew Diamanduros, Pamela Good, Elina Zakin, Varun Chalivendra, and Saud A. Sadiq
Neurobiology of Disease, 2010, Volume 40, Number 1, Page 331
[18]
John W Rose and Noel G Carlson
Expert Opinion on Medical Diagnostics, 2011, Volume 5, Number 3, Page 213
[19]
George P. Christophi and Paul T. Massa
Viral Immunology, 2009, Volume 22, Number 6, Page 371
[20]
Hyesook Yoon, Sachiko I. Blaber, Mekdes Debela, Peter Goettig, Isobel A. Scarisbrick, and Michael Blaber
Biological Chemistry, 2009, Volume 390, Number 4
[21]
M Ban, J L McCauley, R Zuvich, A Baker, L Bergamaschi, M Cox, A Kemppinen, S D'Alfonso, F R Guerini, J Lechner-Scott, F Dudbridge, J Wason, N P Robertson, P L De Jager, D A Hafler, L F Barcellos, A J Ivinson, D Sexton, J R Oksenberg, S L Hauser, M A Pericak-Vance, J Haines, A Compston, and S Sawcer
Genes and Immunity, 2010, Volume 11, Number 8, Page 660
[22]
Richard A Britten, Shamina Mitchell, Angela M. Johnson, Sylvia J. Singletary, Sonia K. Keeney, Julius O. Nyalwidhe, Izabela D. Karbassi, Gyorgy Lonart, Larry D. Sanford, and Richard R. Drake
Health Physics, 2010, Volume 98, Number 2, Page 196
[23]
George P Christophi, Michael Panos, Chad A Hudson, Rebecca L Christophi, Ross C Gruber, Akos T Mersich, Scott D Blystone, Burk Jubelt, and Paul T Massa
Laboratory Investigation, 2009, Volume 89, Number 7, Page 742
[24]
M Talieri, L Li, Y Zheng, D K Alexopoulou, A Soosaipillai, A Scorilas, D Xynopoulos, and E P Diamandis
British Journal of Cancer, 2009, Volume 100, Number 10, Page 1659
[25]
Hyesook Yoon, Sachiko I. Blaber, D. Michael Evans, Julie Trim, Maria Aparecida Juliano, Isobel A. Scarisbrick, and Michael Blaber
Protein Science, 2008, Volume 17, Number 11, Page 1998
[26]
THOMAS COLLINS
Neurology Today, 2008, Volume 8, Number 21, Page 1,16
[27]
Alexander G. Vandell, Nadya Larson, Gurunathan Laxmikanthan, Michael Panos, Sachiko I. Blaber, Michael Blaber, and Isobel A. Scarisbrick
Journal of Neurochemistry, 2008, Volume 107, Number 3, Page 855

Comments (0)

Please log in or register to comment.