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Thomas, Douglas D.

Biological Chemistry

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Volume 389, Issue 7 (Jul 2008)


Prospective of Ras signaling in stem cells

Koushik Chakrabarty
  • 1Department of Molecular Neurobiochemistry, Ruhr University Bochum. D-44780 Bochum, Germany
/ Rolf Heumann
  • 2Department of Molecular Neurobiochemistry, Ruhr University Bochum. D-44780 Bochum, Germany
Published Online: 2008-06-06 | DOI: https://doi.org/10.1515/BC.2008.104


The Ras signaling pathway plays a predominant role during development and controls diverse biological process in all eukaryotic cells. It is a member of the large family of GTPases proteins that binds and hydrolyzes GTP. Ras is a lipid-anchored protein on the intracellular membrane compartments, and cycles between inactive GDP-bound and the signaling competent GTP-bound conformation. Studies have demonstrated Ras to be a central regulator in signal transduction pathways responding to diverse extracellular and intracellular stimuli. Much progress has been made towards delineating specific genes involved in the process of pluripotency and differentiation of stem cells. Here, we discuss recent aspects of Ras signaling pathways in mediating stem cell properties.

Keywords: development; differentiation; proliferation; self-renewal; survival; therapeutic; tyrosine receptor kinase

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Corresponding author

Published Online: 2008-06-06

Published in Print: 2008-07-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.104. Export Citation

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