Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year


IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

Online
ISSN
1437-4315
See all formats and pricing
More options …
Volume 389, Issue 8 (Aug 2008)

Issues

Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution

Stephan Schilling / Claus Wasternack / Hans-Ulrich Demuth
Published Online: 2008-08-19 | DOI: https://doi.org/10.1515/BC.2008.111

Abstract

Several mammalian peptide hormones and proteins from plant and animal origin contain an N-terminal pyroglutamic acid (pGlu) residue. Frequently, the moiety is important in exerting biological function in either mediating interaction with receptors or stabilizing against N-terminal degradation. Glutaminyl cyclases (QCs) were isolated from different plants and animals catalyzing pGlu formation. The recent resolution of the 3D structures of Carica papaya and human QCs clearly supports different evolutionary origins of the proteins, which is also reflected by different enzymatic mechanisms. The broad substrate specificity is revealed by the heterogeneity of physiological substrates of plant and animal QCs, including cytokines, matrix proteins and pathogenesis-related proteins. Moreover, recent evidence also suggests human QC as a catalyst of pGlu formation at the N-terminus of amyloid peptides, which contribute to Alzheimer's disease. Obviously, owing to its biophysical properties, the function of pGlu in plant and animal proteins is very similar in terms of stabilizing or mediating protein and peptide structure. It is possible that the requirement for catalysis of pGlu formation under physiological conditions may have triggered separate evolution of QCs in plants and animals.

Keywords: Alzheimer's disease; posttranslational modification; protein maturation; pyroglutamic acid

About the article

Corresponding author


Published Online: 2008-08-19

Published in Print: 2008-08-01


Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.111.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Y. Diana Liu, Andrew M. Goetze, Randal B. Bass, and Gregory C. Flynn
Journal of Biological Chemistry, 2011, Volume 286, Number 13, Page 11211
[2]
Christina Dammers, Lothar Gremer, Philipp Neudecker, Hans-Ulrich Demuth, Melanie Schwarten, Dieter Willbold, and Michael Massiah
PLOS ONE, 2015, Volume 10, Number 10, Page e0139710
[3]
Yan-Ping Shih, Chi-Chi Chou, Yi-Ling Chen, Kai-Fa Huang, Andrew H.- J. Wang, and Michael Massiah
PLoS ONE, 2014, Volume 9, Number 4, Page e94812
[4]
Hakim MA, Tang Xiao-Peng, Shi-Long YANG, Qiu-Min LU, and Ren LAI
Chinese Journal of Natural Medicines, 2016, Volume 14, Number 8, Page 607
[5]
Mu Yu, San-ling Liu, Pei-bei Sun, Hao Pan, Chang-lin Tian, and Long-hua Zhang
Acta Pharmacologica Sinica, 2016, Volume 37, Number 1, Page 56
[6]
Krysti Todd, Jorge Ghiso, and Agueda Rostagno
Neurobiology of Disease, 2016, Volume 85, Page 130
[7]
Patricia Ortegon, Augusto C. Poot-Hernández, Ernesto Perez-Rueda, and Katya Rodriguez-Vazquez
Computational and Structural Biotechnology Journal, 2015, Volume 13, Page 277
[8]
Verity A. Jackson, Daniel del Toro, Maria Carrasquero, Pietro Roversi, Karl Harlos, Rüdiger Klein, and Elena Seiradake
Structure, 2015, Volume 23, Number 4, Page 774
[9]
Jun Yong Choi, Larissa M. Podust, and William R. Roush
Chemical Reviews, 2014, Volume 114, Number 22, Page 11242
[10]
Krysti Todd, Silvia Fossati, Jorge Ghiso, and Agueda Rostagno
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014, Volume 1842, Number 12, Page 2457
[11]
Daniel Simão, Catarina Pinto, Stefania Piersanti, Anne Weston, Christopher J. Peddie, André E.P. Bastos, Valerio Licursi, Sigrid C. Schwarz, Lucy M. Collinson, Sara Salinas, Margarida Serra, Ana P. Teixeira, Isabella Saggio, Pedro A. Lima, Eric J. Kremer, Giampietro Schiavo, Catarina Brito, and Paula M. Alves
Tissue Engineering Part A, 2015, Volume 21, Number 3-4, Page 654
[12]
Bert-Jan Baas, Ellen Zandvoort, Anna A. Wasiel, and Gerrit J. Poelarends
FEBS Open Bio, 2014, Volume 4, Number 1, Page 651
[13]
Joshua S. Mylne, Ikuko Hara-Nishimura, and K. Johan Rosengren
Functional Plant Biology, 2014, Volume 41, Number 7, Page 671
[14]
Tiziana Cabras, Federica Iavarone, Barbara Manconi, Alessandra Olianas, Maria Teresa Sanna, Massimo Castagnola, and Irene Messana
Bioanalysis, 2014, Volume 6, Number 4, Page 563
[15]
Monika Gupta, Harish Jangra, P. V. Bharatam, and A. K. Madan
ACS Combinatorial Science, 2014, Volume 16, Number 3, Page 101
[16]
Craig M. Dana, Alexandra Dotson-Fagerstrom, Christine M. Roche, Sarala M. Kal, Harshal A. Chokhawala, Harvey W. Blanch, and Douglas S. Clark
Biotechnology and Bioengineering, 2014, Volume 111, Number 4, Page 842
[17]
Steven W. Adamson, Rebecca E. Browning, Chien-Chung Chao, Robert C. Bateman, Wei-Mei Ching, and Shahid Karim
Insect Biochemistry and Molecular Biology, 2013, Volume 43, Number 9, Page 781
[18]
Wei Xu, Yan Peng, Fengqiang Wang, Brittany Paporello, Daisy Richardson, and Hongcheng Liu
Analytical Biochemistry, 2013, Volume 436, Number 1, Page 10
[19]
Birgit Koch, Mirko Buchholz, Michael Wermann, Ulrich Heiser, Stephan Schilling, and Hans-Ulrich Demuth
Chemical Biology & Drug Design, 2012, Volume 80, Number 6, Page 937
[20]
André Mischo, Oliver Ohlenschläger, Karl-Heinz Gührs, and Matthias Görlach
ChemBioChem, 2012, Volume 13, Number 10, Page 1421
[21]
Maike Hartlage-Rübsamen, Katharina Staffa, Alexander Waniek, Michael Wermann, Torsten Hoffmann, Holger Cynis, Stephan Schilling, Hans-Ulrich Demuth, and Steffen Roßner
International Journal of Developmental Neuroscience, 2009, Volume 27, Number 8, Page 825
[22]
Jonas Winkler, Giuliano Armano, J. Nikolaj Dybowski, Oliver Kuhn, Filippo Ledda, and Dominik Heider
Advances in Bioinformatics, 2011, Volume 2011, Page 1
[23]
James K. Chambers, Mayu Mutsuga, Kazuyuki Uchida, and Hiroyuki Nakayama
Amyloid, 2011, Volume 18, Number 2, Page 63
[24]
Haiqing Wang, Konstantin I. Piatkov, Christopher S. Brower, and Alexander Varshavsky
Molecular Cell, 2009, Volume 34, Number 6, Page 686

Comments (0)

Please log in or register to comment.
Log in