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Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Thomas, Douglas D. / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2016: 3.273

CiteScore 2016: 3.01

SCImago Journal Rank (SJR) 2016: 1.679
Source Normalized Impact per Paper (SNIP) 2016: 0.800

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Volume 389, Issue 8 (Aug 2008)


Human monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer

Mona Mostafa Mohamed / Dora Cavallo-Medved
  • 2Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Bonnie F. Sloane
  • 3Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2008-08-19 | DOI: https://doi.org/10.1515/BC.2008.117


Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and here, we examined in vitro the interactions between the human IBC cell line SUM149 and U937 human naive monocytes. We found an altered morphology, enhanced invasiveness and proteolytic activity of SUM149 cells when cultured with U937 cells or in U937-conditioned media (U937-CM). Increases in expression and activity of the cysteine protease cathepsin B and expression of caveolin-1 were also detected in SUM149 cells grown in U937-CM, thus suggesting a contribution of these proteins to the augmented invasion through and proteolysis of the extracellular matrix by the IBC cells.

Keywords: cathepsin B; caveolin-1; co-culture; extracellular matrix; proteolysis

About the article

Corresponding author

Received: 2007-12-14

Accepted: 2008-04-07

Published Online: 2008-08-19

Published in Print: 2008-08-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.117.

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