Jump to ContentJump to Main Navigation
Show Summary Details

Biological Chemistry

Editor-in-Chief: Brüne, Bernhard

Editorial Board Member: Buchner, Johannes / Lei, Ming / Ludwig, Stephan / Sies, Helmut / Turk, Boris / Wittinghofer, Alfred

12 Issues per year

IMPACT FACTOR 2015: 2.710
Rank 142 out of 289 in category Biochemistry & Molecular Biology in the 2015 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 1.607
Source Normalized Impact per Paper (SNIP) 2015: 0.751
Impact per Publication (IPP) 2015: 2.609

See all formats and pricing
Volume 389, Issue 9 (Sep 2008)


Some assembly required: dedicated chaperones in eukaryotic proteasome biogenesis

Andrew R. Kusmierczyk
  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA
/ Mark Hochstrasser
  • 2Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520-8114, USA
Published Online: 2008-08-19 | DOI: https://doi.org/10.1515/BC.2008.130


The 26S proteasome is the key eukaryotic protease responsible for the degradation of intracellular proteins. Protein degradation by the 26S proteasome plays important roles in numerous cellular processes, including the cell cycle, differentiation, apoptosis, and the removal of damaged or misfolded proteins. How this 2.5-MDa complex, composed of at least 32 different polypeptides, is assembled in the first place is not well understood. However, it has become evident that this complicated task is facilitated by a framework of protein factors that chaperone the nascent proteasome through its various stages of assembly. We review here the known proteasome-specific assembly factors, most only recently discovered, and describe their potential roles in proteasome assembly, with an emphasis on the many remaining unanswered questions about this intricate process of assisted self-assembly.

Keywords: assembly factor; maturation; protein complex; yeast

About the article

Corresponding author

Published Online: 2008-08-19

Published in Print: 2008-09-01

Citation Information: Biological Chemistry, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, DOI: https://doi.org/10.1515/BC.2008.130. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Andrea Lehmann, Agathe Niewienda, Katharina Jechow, Katharina Janek, and Cordula Enenkel
Molecular Cell, 2010, Volume 38, Number 6, Page 879
Prashant S. Wani, Michael A. Rowland, Alex Ondracek, Eric J. Deeds, and Jeroen Roelofs
Nature Communications, 2015, Volume 6, Page 6384
Abbas A. Alibhoy, Bennett J. Giardina, Danielle D. Dunton, and Hui-Ling Chiang
Autophagy, 2012, Volume 8, Number 1, Page 29
Elisabet E. Manasanch, Neha Korde, Adriana Zingone, Nishant Tageja, Carlos Fernandez de Larrea, Manisha Bhutani, Peter Wu, Mark Roschewski, and Ola Landgren
Leukemia & Lymphoma, 2014, Volume 55, Number 8, Page 1707
Seung-Wook Shin, Shigeo Murata, and Kazuya Matsumoto
Journal of Mammalian Ova Research, 2013, Volume 30, Number 3, Page 79
Robert J. Tomko and Mark Hochstrasser
Annual Review of Biochemistry, 2013, Volume 82, Number 1, Page 415
Mary J. Kunjappu and Mark Hochstrasser
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014, Volume 1843, Number 1, Page 2
Yasushi Saeki, Akio Toh-e, Tai Kudo, Hitomi Kawamura, and Keiji Tanaka
Cell, 2009, Volume 137, Number 5, Page 900
Senthil K. Radhakrishnan, Candy S. Lee, Patrick Young, Anne Beskow, Jefferson Y. Chan, and Raymond J. Deshaies
Molecular Cell, 2010, Volume 38, Number 1, Page 17
Lynn Bedford, Simon Paine, Paul W. Sheppard, R. John Mayer, and Jeroen Roelofs
Trends in Cell Biology, 2010, Volume 20, Number 7, Page 391
Andrew R Kusmierczyk, Mary J Kunjappu, Roger Y Kim, and Mark Hochstrasser
Nature Structural & Molecular Biology, 2011, Volume 18, Number 5, Page 622
Daniel Finley
Annual Review of Biochemistry, 2009, Volume 78, Number 1, Page 477
Jeroen Roelofs, Soyeon Park, Wilhelm Haas, Geng Tian, Fiona E. McAllister, Ying Huo, Byung-Hoon Lee, Fan Zhang, Yigong Shi, Steven P. Gygi, and Daniel Finley
Nature, 2009, Volume 459, Number 7248, Page 861
Shigeo Murata, Hideki Yashiroda, and Keiji Tanaka
Nature Reviews Molecular Cell Biology, 2009, Volume 10, Number 2, Page 104
Proceedings of the Japan Academy, Series B, 2009, Volume 85, Number 1, Page 12

Comments (0)

Please log in or register to comment.
Log in